This is 1 of 60+ overviews at VitaminDWiki.com All of the overviews can be read in 60+ languages VITAMIN D reduces 29 health problems (as proven by Double-blind random-controlled-trials) Hypertension, Cardiovascular, Back Pain, Diabetes, Influenza, Falls, Hip Fractures, Breast Cancer, Raynaud's pain, Menstrual Pain, C-section and pregnancy risks, Low Birth Weight, Chronic Kidney Disease, Cystic Fibrosis, Rheumatoid Arthritis, TB, Rickets, Respiratory Tract Infection, Lupus, Sickle Cell pain, leg ulcers, traumatic brain injury. Parkinson's Disease, Multiple Sclerosis, Congestive Heart Failure, Middle Ear Infection, Gingivitis Details at http://is.gd/proofvitd

1. Overview MS and vitamin D
Strong evidence: Vitamin D PREVENTS MS and REDUCES MS
symptoms
Clinical trials for MS and Vitamin D INTERVENTION 21 as of Sept 2013
5,000 IU daily for 2 years
Vitamin D being used for MS more than any other disease
3 books with sections on MS and vitamin D
Vitamin D found to be far better than FDA drug for MS
Many MS websites are very pro vitamin D
People at risk of having low vitamin D (elderly, women, blacks,...) have greater incidence of MS
Multiple Sclerosis: number needed to treat with vitamin D may be as low as 1.3 – Meta-analysis Oct 2013
98 pcnt of genes that Vitamin D activates to reduce MS are also activated by Interferon -May 2013
Autoimmune disorder patients in Brazil helped by vitamin D – video and Facebook – Nov 2012 extremely successful - using 20,000
- 140,000 IU daily
Controversy: Which is better: UV or Vitamin D
Sources of UV, in addition to the sun, include your own UV bulb
MS 20X more correlated to UV than other variables – Jan 2011
Lack of UV increased offspring MS - April 2010
Increased sun and vitamin D both reduced MS risk – March 2011
30% less likely to get MS for UV increase of 1000 kJ/m2
Latitude is significantly associated with the prevalence of multiple sclerosis: a meta-analysis Oct 2011
Meta-analysis of >300 studies of MS and latitude
UV suppresses MS but vitamin D might not – March 2010
7% less likely to get MS for each 4 ng increase in vitamin D level in blood
MS prevention by UV is 3X better than prevention by vitamin D levels – Jan 2012
Did sunshine help Ann Romney’s multiple sclerosis? Vitamin D Council Aug 2012
1999 MS Diagnosis ==> Conventional Therapy, Yoga, reflexology, and taking up riding horses out-doors ==> 2001 MS in remission
MS flareup in Spring 2012 Reminder - lowest vitamin D levels occur in the Spring
Less MS (MRI) decline after raising Vitamin D levels – clinical trial Oct 2012
There is a growing mountain of evidence that vitamin D
prevents MS
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2. It has been known for a long time that MS varies with latitude.
CLICK HERE to see the whole journal article from Lancet June 2010
Increased MS for those with less vitamin D - summary of
studies from 2009
CLICK HERE for PDF
However, there has been a decrease in the association of MS
with latitude during the 20th century in the US
Probably due to air conditioning being used in the Southern part of the US
Parkinson (22+) Overview
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3. People with a high level of vitamin D have far less MS and many
other diseases
CLICK HERE for larger image and more charts of disease incidence
Patients like me web site shows that Vitamin D is used by more people
with MS than any other specific disease
Mega Doses of Vitamin D for MS PatientsLikeMe Oct 2012 9,000 messages on forum
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4. MS entry in WikiPedia concerning vitamin D
Decreased sunlight exposure has been linked with a higher risk of MS.
Decreased vitamin D production and intake has been the main biological mechanism used to explain the higher risk among those less
exposed to sun.
The primary aims of therapy are returning function after an attack, preventing new attacks, and preventing disability.
The life expectancy of people with MS is 5 to 10 years lower than that of unaffected people. Almost 40% of patients reach the seventh
decade of life.
Although most patients lose the ability to walk prior to death, 90% are still capable of independent walking at 10 years from onset, and
75% at 15 years.
There is a north-to-south gradient in the northern hemisphere and a south-to-north gradient in the southern hemisphere, with MS being
much less common in people living near the equator. Climate, sunlight and intake of vitamin D have been investigated as possible
causes of the disease that could explain this latitude gradient. However, there are important exceptions to the north-south pattern and
changes in prevalence rates over time; in general, this trend might be disappearing.
Books with large sections on MS and Vitamin D include
CLICK HERE for VitaminDWiki page on the following 2010 book which has 10 pages on vitamin D and MS
Vitamin D3 and Solar Power by Dr. Sorenson has 9 pages of MS and vitamin D
Sunshine and Vitamin D by Frank Murray has 7 pages on MS and vitamin D
Multiple Sclerosis (The Facts) 17 references to Vitamin D Publication Date Oct 2012
$20.00, 96 pages
All vitamin D books at VitaminDWiki including the above
MS trust has a good fact sheet on vitamin D - Feb 2010.pdf
See in VitaminDWiki
Prevention with vitamin D in Multiple Sclerosis is logical – editorial April 2013
Multiple Sclerosis: number needed to treat with vitamin D may be as low as 1.3 – Meta-analysis Oct 2013
98 pcnt of genes that Vitamin D activates to reduce MS are also activated by Interferon -May 2013
Vitamin D prevents multiple sclerosis through multiple mechanisms – Jan 2013 Excellent, 26 pages, many good charts
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5. Vitamin D prevents multiple sclerosis through multiple mechanisms – Jan 2013 Excellent, 26 pages, many good charts
Vitamin D looks promising to deal with MS – review 2013
UV decreases Multiple Sclerosis via cis-urocanic acid (and via vitamin D) – June 2013
Multiple Sclerosis more likely if mother had less than 25 ng of vitamin D – Nov 2012
Multiple Sclerosis and vitamin D – Systematic Review inconclusive Jan 2013
Autoimmune disorder patients in Brazil helped by vitamin D – video and Facebook – Nov 2012
Risk of going from pre-MS to MS reduced 68 percent with 7100 IU vitamin D – RCT Dec 2012
All items in category MS and vitamin D 174 items
MRI detects 32% less of one type of MS lesion for every 10 ng increased vitamin D – April 2012
Vitamin D for MS is becoming mainstream Blog post at VitaminDWiki Feb 2012
Hypothesis - more in sunshine than vitamin D to reduce MS – Feb 2010
Vitamin D far better than fingolimod in reducing MS relapse rate better than the FDA approved drug
10,000 IU vitamin D plus 1200 mg Calcium MS trial April 2010 - investigate if get too much Calcium, noticed that it reduced MS
relapses
20,000 IU vitamin D and MS – less fatigue and relapse Dec 2010
More females have MS – perhaps due to vitamin D deficiency – Feb 2011
MS is related to latitude – conclusion from 321 studies – April 2011
Many people at a MS forum are taking 5,000 to 10,000 IU daily
3X less Multiple Sclerosis with enough vitamin D - Veterans Administration
High vitamin D in moms decreased MS incidence in daughters by 40% – July 2011
MS Clinical trial using up to 10,000 IU of vitamin D – Feb 2012
Hispanics with MS had lower levels of vitamin D which did not vary seasonally – May 2012
MS relapse rate reduced 14 percent for each 4 ng increase in vitamin D – May 2012
Vitamin D reduces multiple sclerosis relapses, but not after interferon treatment – June 2012
Vitamin D enabled a woman with MS to walk long distances again – Oct 2012
Environmental risk factors for MS include latitude and vitamin D – Sept 2012
Concise bullet list of MS information, including symptoms Factoids
most common young adult disease, 2.5 million in the world, Scotland has the most, 5X vary with latitude, symptoms fluctuate,
Vitamin D can both prevent and treat Multiple Sclerosis – review Nov 2012
Vitamin D: one sided debate is published in Multiple Sclerosis Journal – Feb 2013
See also MS on the web
National Library of Medicine
Famous people with MS
UV radiation suppresses experimental autoimmune encephalomyelitis independent of vitamin D production. 2010
full text attached at the bottom of this page
Is hypovitaminosis D one of the environmental risk factors for multiple sclerosis? 2010 full text on-line
Clinical Trial MS 4,000 IU of vitamin D
MS clinical trial (EVIDIMS) to use 10,000 IU of vitamin D – Feb 2012
Multiple Sclerosis ==> 2.6X more Migraine Headache, web, full text online
Multiple Sclerosis ==> 2X more Fractures, web, full text online
Clinical Trials for MS and vitamin D 21 listed Feb 2013
Disease Database links for MS information extensive
Many MS websites Click here for one which recommends such things as 4000 IU vitamin D
BG-12 (dimethyl fumarate) drug submitted to FDA March 2012
about 50% reduction in number of relapses of MS, similar to an increase of 20 ng of vitamin D (see above)
The main difference between vitamin D and BG-12 is patented, so the company can charge a lot of money and make
huge profits
$3 billion annual revenue anticipated
Vitamin D and MS Org Many researchers - Dutch focus
MS Diagnosis and Therapy - professional book May 2012 Amazon look inside the book - many vitamin D entries.
Vitamin D Council Oct 2012
Blog post on MS and Vitamin D - with comments on Vitamin D in multiple sclerosis: implications for assessment and treatment
Vitamin D Council Overview of MS for patients May 2013 (also available as a 2 page PDF
Orkney islands have highest rate of multiple sclerosis in the world – study Guardian Dec 2012
(2010?) 402 per 100,000 inhabitants,1983 190 cases per 100,000 vs Nova Scotia 350 per 100,000
Effect of vitamin D3 supplementation on relapses . . . Norway Aug 2012
20,000 IU weekly (2857 daily average) raised blood level to 48 ng, but did not help in a 96 week double random controlled trial
Smithsonian Magazine May 2013
Multiple sclerosis up 7X in Tehran,1989 - 2005.
In Iran’s central province of Isfahan Multiple sclerosis up 3X 2005 - 2009.
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6. African Americans have a worse time with MS
Google Search for "+"Multiple sclerosis" +african-american difference" got more than 2 million hits Oct 2012
Forum discussion for African Americans with MS
African Americans with MS at VitaminDWiki from various sources
Ways to reduce MS relapse - includes vitamin D- 13 pages May 2010
M Obama's father was another African American with MS living in the
North. suspect he was very low on vitamin D
from 2008 speech: My Dad was our rock. Although he was diagnosed with Multiple Sclerosis in his early thirties, he was our provider,
our champion, our hero. As he got sicker, it got harder for him to walk, it took him longer to get dressed in the morning. But if he was in
pain, he never let on. He never stopped smiling and laughing - even while struggling to button his shirt, even while using two canes to get
himself across the room to give my Mom a kiss. He just woke up a little earlier, and worked a little harder.
Montel Williams has MS, has funded MS research, and is a big
proponent of marijuana to reduce intensity of MS
Interesting to note that Google gets 70,000 hits for +"Multiple sclerosis"
+"vitamin d" +marijuana.
Perhaps vitamin D is as good or better treatment for MS than marijuana
Have been unable to contact the Montel Williams MS organization - their phone is disconnected
Update 2012: Montell Williams was apparently on Oprah show and agreed that Vitamin D helped MS
- - - - - - - - - - - - - - - - -
FACT:At least some MS is associated with a gene variant
FACT: People with MS need higher levels of vitamin D to treat the
symptoms
SPECULATION: Those people with the gene variant need higher levels
of vitamin D in the blood to prevent/treat MS
Vitamin D targets 4 MS genes – May 2011
Mutation of Vitamin D gene is strongly tied to MS – Dec 2011
MS associated with 29 new and 23 previously known gene variants – Aug 2011
MS due to low level of vitamin D may be due to a specific gene – July 2010 CYP27B1
MS and vitamin D may be related by HLA gene – March 2010 (MS Society UK - not VitaminDWiki)
Far more likely to get MS if blood relatives have had MS - MS Org.
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7. - - - - - - - - - - - - - - - - -
vitamin D directly terminates the production of a disease-causing
protein Summary article fromMedical News todayAug 2011
clip from Medical News:
"According to the researchers, the mechanism they identify suggests what might be a new path toward pharmaceutical treatment of MS,
as well as therapies for other autoimmune diseases that might include rheumatoid arthritis, type 1 diabetes, eczema and psoriasis."
The abstract
1,25-Dihydroxyvitamin D3 Ameliorates Th17 Autoimmunity via
Transcriptional Modulation of Interleukin-17A.
Mol Cell Biol. 2011 Sep;31(17):3653-69. Epub 2011 Jul 11.
Joshi S, Pantalena LC, Liu XK, Gaffen SL, Liu H, Rohowsky-Kochan C, Ichiyama K, Yoshimura A, Steinman L, Christakos S, Youssef S.
UMDNJ-New Jersey Medical School, Department of Biochemistry and Molecular Biology, 185 South Orange Ave., E609, Newark, NJ
07103. christak@umdnj.edu.
A new class of inflammatory CD4(+) T cells that produce interleukin-17 (IL-17) (termed Th17) has been identified, which plays a critical
role in numerous inflammatory conditions and autoimmune diseases. The active form of vitamin D, 1,25-dihydroxyvitamin D(3)
1,25(OH)(2)D(3), has a direct repressive effect on the expression of IL-17A in both human and mouse T cells. In vivo treatment of mice
with ongoing experimental autoimmune encephalomyelitis (EAE; a mouse model of multiple sclerosis) diminishes paralysis and
progression of the disease and reduces IL-17A-secreting CD4(+) T cells in the periphery and central nervous system (CNS). The
mechanism of 1,25(OH)(2)D(3) repression of IL-17A expression was found to be transcriptional repression, mediated by the vitamin D
receptor (VDR). Transcription assays, gel shifting, and chromatin immunoprecipitation (ChIP) assays indicate that the negative effect of
1,25(OH)(2)D(3) on IL-17A involves blocking of nuclear factor for activated T cells (NFAT), recruitment of histone deacetylase (HDAC),
sequestration of Runt-related transcription factor 1 (Runx1) by 1,25(OH)(2)D(3)/VDR, and a direct effect of 1,25(OH)(2)D(3) on induction
of Foxp3. Our results describe novel mechanisms and new concepts with regard to vitamin D and the immune system and suggest
therapeutic targets for the control of autoimmune diseases.
PMID: 21746882
Christakos S, has co-authored many vitamin D papers, such as:
Minireview: vitamin d: is there a role in extraskeletal health? Aug 2011
Vitamin D and intestinal calcium absorption. June 2011
NHANES monitoring of serum 25-hydroxyvitamin D: a roundtable summary Nov 2010
Vitamin D: metabolism June 2010 with free PDF
Vitamin D and MS ORG excellent
- - - - - -
MS is in a vicious cycle with vitamin D: low D ==> MS which
lowers vitamin D
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8. Name of this page: Overview MS and vitamin D PERMALINK
This page has been visited 18,030 times.
Related information in categories: Health (Health) »
Multiple Sclerosis (Multiple Sclerosis)
Related information in categories: Overviews (Overviews)
Related information in categories: Treatment by Vitamin D (Treatment by Vitamin D)
Edit this page Comments 6 files attached (Hide)
CLICK HERE for more about deficiencies and vicious cycles
Low vitamin D levels were lower still by time of MS diagnosis – Sept 2012
short url = http://is.gd/msvitd
Page last modified on 14 September, 2013
List of attached files
ID Name desc uploaded Size Downloads Actions
1618 UV better than vitamin D for autoimmune -
2009.pdf
PDF 24 Sep., 2012 by
admin
463.30 Kb 228
908 MS vicious cycle.png 30 Nov., 2011 by
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19.39 Kb 3325
643 ms and genetics.jpg 17 July, 2011 byadmin 21.63 Kb 2960
292 MS down staircase.jpg MSprogress down 11 Nov., 2010 by
admin
49.60 Kb 4172
130 MS Clinical trials - Aug 2010.gif MSClinical trials -Aug
2010
03Aug., 2010 by
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42.01 Kb 1971
129 MS wikipedia.gif MSwikipedia 03Aug., 2010 by
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