14. common alleles in one population, not common in
another population
frequency of disease-associated alleles show
“large heterogeneity between races”
frequency of a risk allele discovered in one
population is not always a strong predictor of the
frequency of that risk allele in other populations
CAD, T2D have been targets of positive natural
selection
local positive selection results in large allele
frequency differences between population
positively selected alleles tend to accumulate in the
top tail of the Fst distribution
allele positive selection
.
17. 0 0.05 0.15 0.25 1
case 1.
0 <= Fst <= 0.05
ignore genetic differentiation
case 2.
0.05 <= Fst < 0.15
genetic differentiation
case 3.
within 0.15 <= Fst
E. Asia strong genetic differentiation
0.04
Africa
within
Europe
Europe case 4.
0.147
0.02 0.25 <= Fst
very strong genetic differentiation
E. Asia. E. Asia
within
Europe Africa
Africa
0.115 0.223 case 5.
Jeju 0.05 1 = Fst
Gyeongju high difference Fst perfect
0.018 between Korea and Jeju isolation
0.073
1
Source: Tishoff SA and Kidd KK.(2004). Nature Genetics Suplement
36:S21-27.