2. Hemophilia
X-linked recessive disorder characterized by deficiency of
coagulation factor.
Hemophilia
Hemophilia A
Hemophilia B
(Chrismas disease)
Deficiency of
coagulation factor
VIII
Deficiency of
coagulation factor
IX
15. Radiological manifestiation of
hemophilic arthropathy
Dense joint effusion Hemoarthrosis
Juxta-articular osteoporosis. Hyperemia of the
epiphysis
Enlargement of the epiphysis Hyperemia of the
epiphysis
Diffuse narrowing of the joint
space
Cartilage destruction
Irregular articular surfaces Bone erosion
Subchondral sclerosis, cystic
changes and marginal
osteophytic lipping.
Premature 2ry
osteoarthritis.
17. KneeKnee
16 +
Bulbous femoral condyles with flattened inferior surface.
Slanting of the tibial plateau.
Widening of the intercondylar notch (due to repeated
hemorrhage in the attachments of the cruciate ligaments).
Squaring of the lower pole of the patella.
28. MRIMRI
1. Hemorrhagic joint effusion.
2. Synovial hemosiderin deposition (low signal intensity on
all pulse sequences with blooming artifact on gradient
echo images).
3. Destruction of the articular surface.
4. Bone marrow edema of the epiphysis.
29.
30. Complications of hemophilicComplications of hemophilic
arthropathy:arthropathy:
1. Premature 2ry osteoarthritis.
2. Premature fusion of the epiphysis with limb shortening.
3. Avascular bone necrosis.
4. Septic arthritis.