1. POSTGRADUATE COURSE IN INFECTIOUS DISEASES, June 2002 This week is the web begins to feature the various lectures/exercises that were presented at a recent scientific meeting organized by the College of Physicians and Academy of Medicine of Malaysia. Infection covers all disciplines of medicine, and despite our earlier optimism that we got infection “licked”, it is very clear with the new millennium infection is going to be with us for a long time. Therefore all doctors must keep pace with new developments in infection in order to provide the best possible care to his patients. I hope these series of lectures/exercise will help you in that direction. I wish to thank all my colleagues who have kindly consented to have their lectures featured in my website.

2. CASE PRESENTATION – HIV/AIDS “ Managing Opportunistic Infections” “ The Twins” – TB and HIV The Headaches that Won’t Go Away “ Doctor, I Can See the Two of You” Fever, Dyspnea and Cough Professor Adeeba Kamarulzaman Dr Christopher Lee Dr Norliza Ariffin Dr Suresh Kumar

3. The Twins TB & HIV

15. Severe or life threatening hepatotoxicity, including fatal fulminant hepatitis has occurred in patients with Nevirapine. It should be interrupted in patients experiencing moderate to severe liver function abnormalities until these return to baseline values. Nevirapine should be permanently discontinued if liver function abnormalities recur upon re-administration Source:Product insert - Viramune

18. Comment on the X-Ray 2 months ago now

26. PTB in early vs late HIV infection Often infiltrates with no cavities Often Cavities CXR Often Negative Often positive Sputum Smear Often resembles primary PTB Often resembles post primary PTB Clinical Picture Late Early Stage of HIV infection Features of PTB

29. Interactions between rifampicin and antiretroviral therapy Efavirenz levels decrease by 25% Efavirenz Nevirapine levels decrease by 37% Nevirapine Saquinavir levels decrease by 84%; if using with ritonavir-use rifampicin 600mgdly or 2-3 times/week Saquinavir (Invirase) Ritonavir levels decrease by 35% Ritonavir Indinavir levels decrease by 89% Indinavir

37. AZT+3TC AZT+ddI d4T+3TC+Nev Crix+Nor+Efa