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Simulation by Design




                                            Dive into ANSYS simulation
                                            Mike Slack
1   © 2011 ANSYS, Inc.   October 10, 2011
Question  Simulation  Insight




2   © 2011 ANSYS, Inc.   October 10, 2011
Complicated Geometries

                • Physiological geometry
                • Complex STL geometries derived from
                  MRI scans
                • Combine with devices




3   © 2011 ANSYS, Inc.   October 10, 2011
Cut Cell Techniques




                A slice through a human nasal cavity meshed using the cut cell meshing
                approach. Local refinement based on proximity and curvature.
4   © 2011 ANSYS, Inc.   October 10, 2011
Respiratory modelling & devices




6   © 2011 ANSYS, Inc.   October 10, 2011
Extended Airways




7   © 2011 ANSYS, Inc.   October 10, 2011
Dry Powder Inhaler




                                                                      Fine drug particles are
                                                                      attached to larger
                                                                      carrier particles.
                                                                      Large particles are
                                                                      easier to mobilise and
                                                                      store.
                                                                      Animation showing the
                                                                      mobilisation of
Courtesy of Sanofi-Aventis – Joint presentation at Respiratory Drug   particles during patient
Delivery conference (2008)                                            inhalation
8    © 2011 ANSYS, Inc.   October 10, 2011
Detachment forces
                                                                                     10.0%
                       Red means
                                                                                                                                        Detachment
                       detachment occurs
                                                                                     8.0%                                               point




                                                             .
                                                                                     6.0%




                                                             Distribution function
                                                                                     4.0%



                                                                                     2.0%



                                                                                     0.0%
                                                                                         1.E-04    1.E-03    1.E-02     1.E-01     1.E+00     1.E+01     1.E+02
                                                                                                    Maximum moment experienced / Maximum withstandable moment


                        .
                                      at
    Vimp                                                  By predicting the forces exerted by the carrier on the
                    Carrier            an                 attached particles this technology allows binary drug
               Ff      R                                  systems to be tailored to suit the delivery technology.
                                Wall
                         N                                                                        Courtesy of Sanofi-Aventis – Joint presentation at
9          © 2011 ANSYS, Inc.          October 10, 2011
                                                                                                  Respiratory Drug Delivery conference (2008)
Ventilation in Medical Equipment




                          Respiration process under the oxygen hood within the
                                            infant incubator
10   © 2011 ANSYS, Inc.    October 10, 2011
Ventilation in Medical Equipment




           Path lines coloured with temperature
                inside the heater chamber




                                                      Schematic graph of the incubator
                 Velocity profile on the fan outlet            components

11   © 2011 ANSYS, Inc.     October 10, 2011
Fabrics and textile design




12   © 2011 ANSYS, Inc.   October 10, 2011
Joint prosthetic understanding and design




                   Sliding distance for osteo-integration           Von Mises stress in the prosthesis




                                     Trabecular tensile and compressive strain
13   © 2011 ANSYS, Inc.    October 10, 2011
Manufacturing processes
                                                         Extrusion multilumen
                                                                 tubes




                             Blow molding




                 Stress distribution in pharmaceutical
                               packaging
14   © 2011 ANSYS, Inc.    October 10, 2011
Spine Modelling




                                             Scan geometery provided
                                             Courtesy of Materialise


15   © 2011 ANSYS, Inc.   October 10, 2011
Stent Artery configuration




                Structural results




                                                 Drug eluting
                                                 Wall diffusion



         Maximum principal stress distribution
16   © 2011 ANSYS, Inc.     October 10, 2011
Modelling flow into porous dressings
     •        Consumer products – diapers, napkins, feminine hygiene, stain
              removal and wound dressings
                                                          Rayon fibers used in
                                                          textile industry




                          Woven scaffold

17   © 2011 ANSYS, Inc.    October 10, 2011
Evaluating the flow of liquid into two
                    different woven materials




            These animations show liquid spreading in a (nonwoven) porous
            pad with different resistances in different locations.


18   © 2011 ANSYS, Inc.   October 10, 2011
19   © 2011 ANSYS, Inc.   October 10, 2011
With
     Without
                                              Flight
     Flight sock                              sock




20    © 2011 ANSYS, Inc.   October 10, 2011
Summary

                    Simulation fits many different questions and scales


                    A broad range of physics are available in the tool box


                    Value of insight = designed with confidence




21   © 2011 ANSYS, Inc.   October 10, 2011

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Simulation in Design - Dive into ANSYS simulation

  • 1. Simulation by Design Dive into ANSYS simulation Mike Slack 1 © 2011 ANSYS, Inc. October 10, 2011
  • 2. Question  Simulation  Insight 2 © 2011 ANSYS, Inc. October 10, 2011
  • 3. Complicated Geometries • Physiological geometry • Complex STL geometries derived from MRI scans • Combine with devices 3 © 2011 ANSYS, Inc. October 10, 2011
  • 4. Cut Cell Techniques A slice through a human nasal cavity meshed using the cut cell meshing approach. Local refinement based on proximity and curvature. 4 © 2011 ANSYS, Inc. October 10, 2011
  • 5. Respiratory modelling & devices 6 © 2011 ANSYS, Inc. October 10, 2011
  • 6. Extended Airways 7 © 2011 ANSYS, Inc. October 10, 2011
  • 7. Dry Powder Inhaler Fine drug particles are attached to larger carrier particles. Large particles are easier to mobilise and store. Animation showing the mobilisation of Courtesy of Sanofi-Aventis – Joint presentation at Respiratory Drug particles during patient Delivery conference (2008) inhalation 8 © 2011 ANSYS, Inc. October 10, 2011
  • 8. Detachment forces 10.0% Red means Detachment detachment occurs 8.0% point . 6.0% Distribution function 4.0% 2.0% 0.0% 1.E-04 1.E-03 1.E-02 1.E-01 1.E+00 1.E+01 1.E+02 Maximum moment experienced / Maximum withstandable moment .  at Vimp By predicting the forces exerted by the carrier on the Carrier an attached particles this technology allows binary drug Ff R systems to be tailored to suit the delivery technology. Wall N Courtesy of Sanofi-Aventis – Joint presentation at 9 © 2011 ANSYS, Inc. October 10, 2011 Respiratory Drug Delivery conference (2008)
  • 9. Ventilation in Medical Equipment Respiration process under the oxygen hood within the infant incubator 10 © 2011 ANSYS, Inc. October 10, 2011
  • 10. Ventilation in Medical Equipment Path lines coloured with temperature inside the heater chamber Schematic graph of the incubator Velocity profile on the fan outlet components 11 © 2011 ANSYS, Inc. October 10, 2011
  • 11. Fabrics and textile design 12 © 2011 ANSYS, Inc. October 10, 2011
  • 12. Joint prosthetic understanding and design Sliding distance for osteo-integration Von Mises stress in the prosthesis Trabecular tensile and compressive strain 13 © 2011 ANSYS, Inc. October 10, 2011
  • 13. Manufacturing processes Extrusion multilumen tubes Blow molding Stress distribution in pharmaceutical packaging 14 © 2011 ANSYS, Inc. October 10, 2011
  • 14. Spine Modelling Scan geometery provided Courtesy of Materialise 15 © 2011 ANSYS, Inc. October 10, 2011
  • 15. Stent Artery configuration Structural results Drug eluting Wall diffusion Maximum principal stress distribution 16 © 2011 ANSYS, Inc. October 10, 2011
  • 16. Modelling flow into porous dressings • Consumer products – diapers, napkins, feminine hygiene, stain removal and wound dressings Rayon fibers used in textile industry Woven scaffold 17 © 2011 ANSYS, Inc. October 10, 2011
  • 17. Evaluating the flow of liquid into two different woven materials These animations show liquid spreading in a (nonwoven) porous pad with different resistances in different locations. 18 © 2011 ANSYS, Inc. October 10, 2011
  • 18. 19 © 2011 ANSYS, Inc. October 10, 2011
  • 19. With Without Flight Flight sock sock 20 © 2011 ANSYS, Inc. October 10, 2011
  • 20. Summary Simulation fits many different questions and scales A broad range of physics are available in the tool box Value of insight = designed with confidence 21 © 2011 ANSYS, Inc. October 10, 2011