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Silent Brain Death   The problem of donor identification. F Procaccio , L Rizzato,  A Ricci,  A Nanni Costa Italian Transplant National Centre Rome -  Italy ISODP - Buenos Aires 2011
POTENTIAL  DBD  DONOR  A person  w hose clinical condition is suspected to  fulfill brain death criteria. ELIGIBLE  DBD  DONOR A  medically suitable  person who has been  declared dead   based on neurologic criteria as stipulated by the law of the relevant jurisdiction. Critical pathways for organ donation * POSSIBLE DECEASED ORGAN DONOR A patient with a devastating brain injury or lesion  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Donation after BrainDeath ( DBD ) Treating physician  to identify/refer a potential donor  * The “dead donor rule” must be respected .  That is, patients may only become donors after death, and the recovery of organs must not cause a donor’s death . ,[object Object],[object Object],[object Object],[object Object],[object Object],UTILIZED  DBD  DONOR An actual donor from whom  at least one organ was transplanted. Donation after Circulatory Death ( DCD )
Cadaveric Organ Procurement Principles in Italy ,[object Object],[object Object],[object Object],[object Object]
Italian Regions  – 2010 vs 2011 *  preliminary data  August 31, 2011 Declared BD p.m.p. 20 p.m.p. 80 p.m.p.
Veneto Region ICUs a confidential prospective study ,[object Object],[object Object],[object Object],F Procaccio et al.  Deaths with acute cerebral lesion in the Veneto Region.  Minerva Anestesiol, 2001
Indicators :  Potential   of donation Brain Death declarations PROC 2 =  ------------------   % Deaths with    Acute Cerebral Lesions in ICU Benchmarking 50-65 %
[object Object],[object Object],[object Object],[object Object],F Procaccio, L Rizzato, A Ricci, S Venettoni, Nanni Costa Organs&Tissues&Cells, 2008 – Transplant Proc ,2010 Italian Registry of Deaths with  Acute Cerebral Lesion in ICU
The “ silent  ” Brain Death ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],F Procaccio et al.  Transplant Proc, 2010
 
Hypothesis of key factors for  lost  (silent)  Brain Deaths ,[object Object],[object Object],[object Object]
Utilized  DBD  Donors Age years Median Mean
Italian Registry – DACL in ICU Age Actual Donors Deaths with cerebral lesion Brain Deaths The “ silent  ” BD vs Age F Procaccio et al.  Transplant Proc, 2010
Deaths with ACL in ICU Age  vs   BD declaration  vs   Donors BD declared AGE DONORS
Prospective Veneto Region Study Oct 2010 - Jan 2011 – 39 Hospitals/ICUs 523 cases ,[object Object],[object Object],[object Object],[object Object],[object Object],DACL: Total 350  p.m.p.   -  110  p.m.p.  in ICU  (73% Neuro ICUs)   Procaccio, Munari, Frigo et al. 2011
Deaths with ACL In ICU vs  BD Declaration 391 DLCA 128 BDs 33% range   17/22  ( 77 %) 26/50  ( 52 %) 7/50  ( 14 %) Deaths  With Acute Cerebral  Lesion 4 ICUS  around  50 5 ICUs  20-40 7 ICUs  1-10 16 ICUs Region  x BD DACL DACL BD ICUs
GOAL 1 :   Every death in ICU will lead to a timely decision regarding donation ,[object Object],[object Object],[object Object],[object Object],[object Object],ICU Staff ,[object Object],[object Object],[object Object]
ICU DDC The ICU  Donation Champions  &  the Deceased Donor Coordination Tx Hospital
2010
en sciene & en route Aggressive treatment circulation ventilation ICP control Max treatment Organs Brain All they need is flow recovery Brain Death Organ Donor
Transplant Proc, 2010 As neurointensive treatment  can improve outcomes  and reduce  “silent”  BDs, more DBD donors exist where patients with acute cerebral lesion are better treated.
Do enhance  ICU’s SKills & Motivation Research Recognition in organ donation

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Silent Brain Death Identification and Organ Donation

  • 1. Silent Brain Death The problem of donor identification. F Procaccio , L Rizzato, A Ricci, A Nanni Costa Italian Transplant National Centre Rome - Italy ISODP - Buenos Aires 2011
  • 2.
  • 3.
  • 4. Italian Regions – 2010 vs 2011 * preliminary data August 31, 2011 Declared BD p.m.p. 20 p.m.p. 80 p.m.p.
  • 5.
  • 6. Indicators : Potential of donation Brain Death declarations PROC 2 = ------------------ % Deaths with Acute Cerebral Lesions in ICU Benchmarking 50-65 %
  • 7.
  • 8.
  • 9.  
  • 10.
  • 11. Utilized DBD Donors Age years Median Mean
  • 12. Italian Registry – DACL in ICU Age Actual Donors Deaths with cerebral lesion Brain Deaths The “ silent ” BD vs Age F Procaccio et al. Transplant Proc, 2010
  • 13. Deaths with ACL in ICU Age vs BD declaration vs Donors BD declared AGE DONORS
  • 14.
  • 15. Deaths with ACL In ICU vs BD Declaration 391 DLCA 128 BDs 33% range 17/22 ( 77 %) 26/50 ( 52 %) 7/50 ( 14 %) Deaths With Acute Cerebral Lesion 4 ICUS around 50 5 ICUs 20-40 7 ICUs 1-10 16 ICUs Region x BD DACL DACL BD ICUs
  • 16.
  • 17. ICU DDC The ICU Donation Champions & the Deceased Donor Coordination Tx Hospital
  • 18. 2010
  • 19. en sciene & en route Aggressive treatment circulation ventilation ICP control Max treatment Organs Brain All they need is flow recovery Brain Death Organ Donor
  • 20. Transplant Proc, 2010 As neurointensive treatment can improve outcomes and reduce “silent” BDs, more DBD donors exist where patients with acute cerebral lesion are better treated.
  • 21. Do enhance ICU’s SKills & Motivation Research Recognition in organ donation