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5. Steroids the Sleaziest of Drugs
Steroids are fast catching up with
antibiotics as the most abused class of
drugs in doctor's black bag.
High doses of corticosteroids and
other immunosuppressive agents cause AIDS
Mohammed Ali Al-Bayati Ph.D
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6.
Discuss the pharmacological effects of glucocorticoids
Side effects and contraindications of steroid use
Distinguish the short term from long term therapy
Describe possible indications & regimens for their use in oral
surgery
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19. Carbohydrate,
Protein & Fat Metabolism:
Gluconeogenesis
Glycogen deposition in liver
(activation of hepatic glycogen synthase)
Negative nitrogen balance & hyperglycaemia
Redistribution of Fat
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20.
Aldosterone is more important
Act on D.T. & C.D. of kidney
◦
Na+ reabsorption
◦
Urinary excretion of K+ and H+
Calcium excretion by the kidney
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22.
Mild euphoria
Maintain level of sensory perception & normal level of
excitability of neurones
HIGH DOSES LOWER SIEZURE THRESHOLD
- CAUTIOUS USE IN EPILEPTICS
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37.
Use of Corticosteroids in Oral Surgery; J Oral Maxillofac Surg 50:270-277, 1992; Lisa Gersema, Karen
Baker
Efficacy and safety of steroid use for postoperative pain relief; The journal of bone & joint surgery ·
JBJS.Org; Volume 88-A · number 6 · June 2006
Supplemental corticosteroids for dental patients with adrenal insufficiency :Reconsideration of the
problem;Craig S. Miller, James W. Little,; Donald A. Falace, JADA, Vol. 132, November 2001; 1570
Corticosteroids and Oral Surgery: Jason Bodnar, Anesth Prog 48:130-132 2001
Perioperative Glucocorticoid Coverage - A Reassessment 42 Years After Emergence of a Problem; Michael
Salem, Robert E. Tainsh, Annals Of Surgery;April 1994;Vol. 219, No. 4,416-425
Textbook of Modern Pharmacology with Clinical Applications by Charles R Craig
Textbook of Review of Medical Physiology by William Ganong
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