principles of medicine report

1. Goodpasteur Syndrome

2. Syndrome
 a group of symptoms that together are
characteristic of a specific disorder, di
sease, or the like.

3. Hemosiderosis
 Pulmonary hemosiderosis (PH) is characterized by
repeated episodes of intra-alveolar bleeding that
lead to abnormal accumulation of iron as
hemosiderin in alveolar macrophages and
subsequent development of pulmonary fibrosis
and severe anemia

4. Goodpasteur Syndrome
 Goodpasture syndrome is a pulmonary-renal syndrome, which is a
group of acute illnesses involving the kidneys and lungs.
 A chronic pulmonary hemosiderosis, usually associated with
glomerulonephritis and characterized by a cough with
hemoptysis, dyspnea, anemia and progressive renal failure
 Glomerulonephritis
 anti-glomerular basement membrane (GBM) antibodies -----
(collagen Killers)
 bleeding in the lungs

5. GPS
 immune cells produce antibodies against a specific region
of collagen. The antibodies attack the collagen in the
lungs and kidneys.

6. IT’S A KIDNEY…

7. WHY NAME IT
GOODPASTURE ?

8. Ernest Goodpasture
 describedthe syndrome during the
influenza pandemic of 1919 when he
reported on a patient who died from
bleeding in the lungs and kidney failure.

9. WHAT CAUSES IT?
 Hereditary
 Autoimmune Disorder
 Smoking
 Hydrocarbon solvents
Men are eight times more likely to
be affected than women

10. Manifestations:
 Loss of appetite, fatigue, and weakness are common early symptoms.
 Lung symptoms may include:
 Coughing up blood(hemoptysis)
 Dry cough
 Shortness of breath
 Kidney and other symptoms include:
 Bloody urine
 Burning sensation when urinating
 Nausea and vomiting
 Pale skin
 Swelling (edema) in any area of the body, especially in the legs

11. Diagnostics:
 Urinalysis
 Blood test
 Chest x ray
 Biopsy

13. Treatment:
 Corticosteroid medications (such as prednisone)
 immunosuppressive medications, such as
cyclophosphamide
 Plasmapheresis
 removes whole blood from the body and replaces the plasma with
fluid, protein, or donated plasma

14. What if its Severe??
Hemodialysis
Kidney Transplant

15. Additional points to remember
 Never sniff glue or siphon gasoline with your
mouth, which expose the lungs to hydrocarbon solvents
 People who smoke or use hair dyes appear to be at
increased risk for this condition. Exposure to hydrocarbon
fumes, metallic dust, and certain drugs may also raise a
person’s risk.

16. PARANOID BOX :
“Oh no… I might have Goodpasture’s Syndrome…”