1. STUDY SHEDS LIGHT ON THE
ASSEMBLY OF RIBOSOME AND
DEMYSTIFYING THE IMMORTALITY
OF CANCER CELLS
JUAN JOSE CASTRO PALACIO
MEDICAL STUDENT
JULY 23 2012

4. Telomereis the
estructure of the
chromosomes more
asociated with
cellular aging
The telomerase
activity make that the
cell division be
uncontroled, and the
cancer appears

5. A new study by researchers at
Brigham and Women's Hospital
(BWH) shows that a common form
of anxiety, known as phobic
anxiety, was associated with
shorter telomeres in middle-aged
and older women. The study
suggests that phobic anxiety is a
possible risk factor for
accelerated aging.

6. Telomeres are DNA-
protein complexes at the
ends of chromosomes
This structure prevents
the fusion with others
chromosomes
Telomeres are
considered markers of
biological or cellular
aging.

7. researchers had obtained blood
samples from 5,243 women, age
42 to 69 years
Been related the anxiety and the
length of the telomeres.
The shortest telomeres are asociated
with the anxiety in the persons.

8. The psicological stress
produces an endless of
molecular process y the
organism.
The immune cell function,
oxidative stress or activity
telomerase, are some impact
that the psicological stress
produce in the cell.

9. OBSERVATION
The psicological stress caused by the anxiety
produces many cellular process that can change
the course of the aging. In some cases this aging
brings the risk of cancer, heart desease,
dementia and mortality. This study provides
many cuestion about the real process of the
shortening of the telomeres and the security
measures for the people.

10. DEMYSTIFYING
THE IMMORTALITY
OF CANCER CELLS
In cancer cells, normal mechanisms
governing the cellular life cycle have
gone haywire. Cancer cells continue to
divide indefinitely, without ever dying
off, thus creating rapidly growing
tumors. EPFL scientists have
discovered a protein complex involved
this deregulated process, and hope to
be able to exploit it to stop tumor
formation in its tracks.

11. The telomere of the cell play a
big role in the division of the
cell.
This part of the chromosomes
defined the lifespand of the
cell.
The telomeres are controlled by the
telomerase, a enzime charge of the
creation of the secuence of ADN in the
telomeres.

12. In most of the cell of the organism the
telomerase are inactive to meet with the
internal clock, and give to the cell at least
60 division.
In the cancer the cell have a mutation,
because the telomerase are active , and
regenerates the telomere
In this form the cell can
divide indefinitely, in
others words is inmortal

13. The scientist found a complex of
three proteins that prevents the
activity of the telomerase, adhering
to the telomere
In the cancer this protein complex
started his activity very late, and the
telomerase acts in the telomere.

14. OBSERVATION
The role that play the diferents proteins in the
cell shows the complicated proces in the
division. Surely in the division are involved many
others factors, but we can see that the smallest
mutation produces a variety of deseases like the
cancer. This kinds of studies give us many tools
to combat this pathologies.

15. MEDICAL UTILITY
Anxiety linked to shortened telomeres, accelerated
aging: research
• Many people can considerate the anxiety like
a form of aging, in this form the health
autorities can take action for prevent the
shortening of the telomeres

16. MEDICAL UTILITY
Anxiety linked to shortened telomeres, accelerated
aging: research
• The diet and somes drugs can be used for
reduce the oxidative stress in the cell.
• The profundization of the study of the real
asociation between telomeres and anxiety,
can tell us if the small telomers its a factor to
anxiety or the anxiety make the shortening of
this structures

17. MEDICAL UTILITY
Demystifying the immortality of cancer cells
• The inhibition of the telomerase can be on of
the mathods of stop the cellular division, so
the cancer process will be controlled

18. MEDICAL UTILITY
Demystifying the immortality of cancer cells
• Knowing that the protein complex stop the
activity of the telomerase, the researchers can
synthetize it, and develop a form to transport
the complex to te telomeres before the
telomerase act in the DNA structure.

19. BIBLIOGRAPHY
• Epel ES, Blackburn EH, Lin J, Dhabhar FS, Adler NE, Morrow
JD, Gawthon RM. Acelerated telomere shortening in response
to life stress. Proc Natl Acad Sci 2004; 101: 17312-17315
• Cooper Geoffrey M, cooper s celula, tercera edición , Editorial
Marban.
• Anxiety linked to shortened telomeres, accelerated
aging:research. Medical xpress. Published on July 6, 2012
• Demystifying the immortality of cancer cells.
Actualités.Published on july 5, 2012
• Martinez S, Lina Maria. Biología Molecular. 5 ed Medellín:
UPB. Fac Medicina