![Stereochemistry of Formoterol Formoterol molecules (R,R) ,[object Object]](https://image.slidesharecdn.com/stereochemistryofarformoteroltartrate-100326013110-phpapp01/85/stereochemistry-of-arformoterol-tartrate-1-320.jpg)
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Stereochemistry Of Arformoterol Tartrate
- 2. It has two chiral centres, each of it can exist in two possible combinations and this give rise to four combinations: (R,R), (R,S), (S,R) and (S,S)Chiral carbon
- 4. Similarly, (R,S) and (S,R) are also an enantiomeric pair too.(R) (S) (R,S) Formoterol (S,R) Formoterol
- 7. The R-enantiomer and the S-enantiomer show different biological activity in the racemic drug.
- 8. For example, studies show that formoterol (R,R / S,S) may have proinflammatory properties since it contain (S,S) isomer. The (S,S) isomer is not biologically inert and has an inflammatory effect on T cells.
- 9. Thus, the bronchodilating and antiinflammatory effect of formoterol can be attributed entirely to the (R,R) enantiomer.
- 10. Since single enantiomer has advantages over the racemic, scientists has finally purified out the (R,R) isomer from the racemicformoterol and named the compound as arformoteroltartrate.