CAN GmbH is a nanotechnology company located in Hamburg, Germany that specializes in producing and functionalizing nanoparticulate materials. It was founded in 2005 as a public-private partnership between research institutions and industry. CAN GmbH conducts contract research, develops its own nanoparticle products, and collaborates with academic and industry partners on projects in areas such as cosmetics, medicine, and technical applications.

1. • CAN GmbH – Center for Applied Nanotechnology GmbH
• Concepts from Science to Industry
• Dr. Frank Schröder-Oeynhausen
Centrum für Angewandte Nanotechnologie (CAN) GmbH 1

2. Nanotechnology
in Germany
Center for Applied Nanotechnology (CAN) GmbH 2

3. Nanotechnology
in Hamburg
Borstel: Lübeck: UKSH
UKE, HPI: Nanobiomedicine Lasercenter,
Nanobiomedicine, Nanobiomedicine
Molecular Imaging University HH:
Nanoparticle synthesis,
Nanomaterials,
Nanobiochemistry,
Energy Research,
DESY: Catalysis,
Characterisation, Nanostructures,
Dynamics on the Nanoanalytics, CAN GmbH
nanometer scale Nanodevices,
EMBL: Theory of Nanosystems
Activity: Nanobiochemistry of
proteins
GKSS:
huge
Membranes,
Medium Nanomaterials
TUHH:
small BNI: Nanomaterials for
Nanobiomedicine Transport Systems,
CNTs, Polymers, Fuel
Cell Systems
Center for Applied Nanotechnology (CAN) GmbH

4. Nanotechnology
Properties
Surface to
volume ratio
102
size
100
1 nm 1µm 1mm 1m
10-2
10-4
10-6
10-8
Optically
transparent
Center for Applied Nanotechnology (CAN) GmbH

5. Company Profile
Mission
Our main expertise is on the production and
functionalization of nanoparticulate and nanocomposite
materials, encapsulation of active ingredients as well as
development of nanoparticle-based biological and
medical markers for the cosmetics-, consumables- and
pharma industry.
We produce nanoparticles of highest quality, offers
contract research and development services in the area of
nanotechnology and participates in national and
international research programs.
5 nm
Mission: We offer nanoparticles for your purpose!
Center for Applied Nanotechnology (CAN) GmbH 5

6. Company Profile
General Conditions
Academia CAN GmbH Market
Science
Collaborative
Publications Research
Patents
Project Management Own
Products
Standardization
Prototyping
Contract
Benchmarking Research
Products
Center for Applied Nanotechnology (CAN) GmbH 6

7. Company Profile
Concept
Business Model: Public Private Partnership (PPP)
Founded: November 2005
Location: Hamburg
Staff: 25 + 6 (today)
Sales: 1.318.000 € (2009)
Partners: Verein zur Förderung der Nanotechnologie e.V. (65,2 %)
Free and Hanseatic City of Hamburg (24,8 %)
University Hamburg (10 %)
Subsidiaries: Screening Port Hamburg GmbH. (80,2 %)
Head of Supervisory Board: Prof. Dr. Klaus-Peter Wittern
Chief Scientific Officer: Prof. Dr. Horst Weller
Chief Operation Officer: Dr. Frank Schröder-Oeynhausen
Center for Applied Nanotechnology (CAN) GmbH 7

8. Business Segments
Fields of Business Transfer Model:
• I. Cosmetics / Flavours: Contract Research
Thickener, Emulsions, Encapsulation
• II. Medicine / Medical Technology:
Nanoparticles for Diagnostics Own Products
Drug Delivery Systems International Collaboration
Analytics / Toxicity Service Tox-Tests
Analyses of Nanostructures Service Analytics
Assay Development
• III. Technical Applications:
Security Labels Contract Research (conf.)
Nanostructured Functionalized Layers National Collaboration
Center for Applied Nanotechnology (CAN) GmbH 8

9. Business Segment I: Cosmetics
Nanoparticles
• Synthesis of ZnO - and TiO2 - nanoparticles
Contract
• Modification of nanoparticles Research
Polymers
• Thickener für water- and oilbased systems
• Systems for hair-repair
• Emulsions
• Mucoadhesive polymers
Encapsulation
• Encapsulation of drugs and flavours
• Water/Oil - nanoemulsions
Contact:
Personal Care: Dr. Marcel Ruppert (ruppert@can-hamburg.de)
Hair Care: Dr. Marc Thiry (thiry@can-hamburg.de)
Center for Applied Nanotechnology (CAN) GmbH 9

10. Business Segment II: Medicine
Nanoparticles: Properties
Ligands define stability and chemistry:
• Biocompatibility
• Coupling mechanisms
Core defines properties
depending on size:
• Colour
5 nm • Magnetism
• Conductivity
• Thermodynamics
5 nm
Center for Applied Nanotechnology (CAN) GmbH

11. Business Segment II: Medicine
Nanoparticles: CANdot® Series A
Features
• Fluorescent Nanoparticles
• Emission max: 500 to 620 nm
• High reproducible properties
• Soluble in water or non-polar organic
solvents
• High physical and chemical stability
Structure
• CdSe/CdS/ZnS dots
• Core-shell-shell structure
• Scalable core size
• Core and core-shell particles available, too Own
Product
Center for Applied Nanotechnology (CAN) GmbH 12

12. Business Segment II: Medicine
Nanoparticles: CANdot® Series M
Features
• Magnetic nanoparticles
• Diameter between 5 and 30 nm
Own
• Small size distribution
Product
• Soluble in water or non-polar, organic
solvents
Structure magnet
• FeOX nanoparticles
• Hydrophobic acids for organic solvents
• Hydrophilic polymers for water
• Doping possible
Center for Applied Nanotechnology (CAN) GmbH 18

13. Business Segment II: Medicine
Nanoparticles: Synthesis
A) Vapour Deposition (PVD / CVD) “Hot Injection Process”
B) Sol-Gel Technique
C) Wet-Chemistry Advantages
• universal applicable
• well known
• broad temperature range
Disadvantages
• temperature profile hard to
control
• slow mixing after injection
• “up-scaling” difficult
Center for Applied Nanotechnology (CAN) GmbH 13

14. Business Segment II: Medicine
Nanoparticles: Synthesis
A) Vapour Deposition (PVD / CVD) “Flow Synthesis”
B) Sol-Gel Technique
C) Wet-Chemistry
Center for Applied Nanotechnology (CAN) GmbH 14

15. Business Segment II: Medicine
Nanoparticles: Synthesis
Center for Applied Nanotechnology (CAN) GmbH 15

16. Business Segment II: Medicine
Nanoparticles: Properties
5 nm
Center for Applied Nanotechnology (CAN) GmbH

17. Service
Analytics

18. Business Segment II: Medicine
Toxicity of Nanoparticles
quality
skin
lung
ligands
intestine
shells
ICC
shape
size
nanoparticle modification interaction
Center for Applied Nanotechnology (CAN) GmbH 19

19. Business Segment II: Medicine
Toxicity of Nanoparticles
Example for studying the interaction between nanoparticles and cell system
• Red: Epithelial-cells (lung), stained with Draq5 (nucleus)
• Blue: CdSe-CdS nanoparticles with different blockcopolymer-labels, located in the cell
cytosol and the cell membrane
Service
Contact:
Toxicity: Dr. Thomas Frahm (frahm@can-hamburg.de)
20
Center for Applied Nanotechnology (CAN) GmbH

20. EU project VIBRANT
• The goal of VIBRANT is the development of nano-
technology-based systems for diabetes diagnosis
and/or therapy. from the pharmaceutical industry.
• CAN and UHH will provide a contrast agent
providing a stable and high signal intensity, which is
highly specific to the cell type, but low toxicity,
http://www.fp7-vibrant.eu/
Ultimately, VIBRANT will deliver β-
cell specific, functionally optimized
nanoconstructs and defined know-how
for in vivo applications in non-human
Ihr Ansprechpartner:
primates and humans with regard to
Dr. Theo Schotten (schotten@can-hamburg.de)
quantification of BCM, imaging of

21. Specific coupling agent
The Nanocontainer
Superparamagnetic particle
Quantum Dots
Biocompatible Shell
Anchor/Linker
Ligand
~ 20 - 300 nm
Micelle or Vesicle
Centrum für Angewandte Nanotechnologie GmbH

22. Outline
• EU Framework 7 Large Scale Project
• Idea and coordination: CAN GmbH
• Duration: 7/2009 to 6/2013
• Grant: 8 Mio EUR
• Scientists from nine research institutes from five EU-countries
(Belgium, Spain, Denmark, Sweden and Germany
• Industrial Advisory Board: big pharma.
http://www.fp7-vibrant.eu/
International
Ihr Ansprechpartner:
Dr. Theo Schotten (schotten@can-hamburg.de) collaboration

23. The “Axis of Excellence”*
International
collaboration
*) R = 0.989! ;-)

24. Business Segment III: Technical Applications
Security Labels
CANdots® Series X as Security Labels:
Contract
• Activation of the host lattice by doping with rare-earth elements
• Reproducible Shape of Particles (spheres to ellipsoids, synthesis specific) Research
• Reproducible Size of Particles (7 to 40 nm, material- and synthesis specific) (conf.)
• Physical und Chemical Stability (photo stabilized, inert to high temperatures, acids, bases und
organic solvents)
Contact:
Polymers: Dr. Jan Niehaus (niehaus@can-hamburg.de)
Center for Applied Nanotechnology (CAN) GmbH 25

25. Business Segment III: Technical Applications
New Concept of a Solar Cell
Quantum Dot-
Carbon Nanotube
Composites
B.Hernandez-Juárez, C. Klinke, A.Kornowski, H. Weller
Institute of Physical Chemistry. Universität Hamburg.
Center for Applied Nanotechnology (CAN) GmbH

26. Business Segment III: Technical Applications
New Concept of a Solar Cell
Collaboration
e.g. Photovoltaics
h+ with Academia
e
e-
e
e
e
e
e h
CB
VB
conductive polymer
Center for Applied Nanotechnology (CAN) GmbH

27. Business Model:
Collaborative Research Projects
Example: VIBRANT, EU-Project
• EU Framework 7 – NMP – Large Scale Project
Nanosciences, Nanotechnologies, Materials and New
Production Technologies
• Goal of the project: Development of marker systems for diabetes diagnostics
• Coordination: CAN GmbH
• Timeframe: 7/2009 to 6/2013
• Budget: about 8 Mio EUR
• Scientists from nine research institutes from five EU-countries (Belgium, Spain, Denmark,
Sweden and Germany)
• Industrial Advisory Board
• Internet: www.fp7-vibrant.eu
• Coordination of the application process (two step process)
Centrum für Angewandte Nanotechnologie (CAN) GmbH 28

28. Business Model:
Patents, Products
Intellectual Property Rights owned by CAN
1. Method for producing alkaline earth sulfate nanoparticles (Basolute I)
2. Process for preparing dispersible sulfate nanoparticles (Basolute II)
3. Luminescent core/shell nanoparticles
4. Core/shell nanoparticles suitable for (F)RET-assays
5. Synthesis of nanoparticles comprising metal(III)vanadate
6. Security printing liquid and method using nanoparticles
7. Paramagnetic nanoparticles
8. Synthesis of nanoparticles (Dotnan)
9. X-Ray opaque dental nanomaterials
10. Postsynthetic polyacid/base modification of nanoparticles
11. InP nanoparticles and method for their manufacture
12. Reactor for the synthesis of nanoparticles CANdots Series A
13. …
CANdots Series X
Center for Applied Nanotechnology (CAN) GmbH 29

29. Business Model:
Contract Research
First Contact
• Discussion on ideas / problems / requests
• Non Disclosure Agreement (NDA)
Concept
Agreement on:
• R&D goals
• Timeframe
• Budget
• Patent- and License issues
• Other partners
• Legal issues
Contracts
• Small jobs (< 10 T€)
• Feasibility Studies (< 50 T€)
• R&D Contracts (> 50 T€)
Centrum für Angewandte Nanotechnologie (CAN) GmbH 30

30. Business Model:
Service
Consulting and Service
• Studies
• Surveys
CAN-Analytics
• Scanning Electron Microscopy (SEM / TEM)
• Static and Dynamic Light Scattering (SLS / DLS)
• X-Rax Scattering (SAXS / WAXS)
• Atomic Force Microscopy (AFM)
• Infrared Spectroscopy
• Mass-Spectrometry (MS, MALDI-MS)
• Absorption Spectroscopy (UV-Vis, NIR)
• Fluorescence Optical Microscopy
• Confocal Laser-Scanning Microscopy
• Electron Spin Resonance-Spectroscopy
• SQUID Magnetometry
• Chromatography
• Rheology
Center for Applied Nanotechnology (CAN) GmbH 31

31. CAN GmbH:
Partner
University of Hamburg
Cooperation Contracts
Companies:
Beiersdorf AG www.beiersdorf.com
Eppendorf AG www.eppendorf.com
BODE Chemie GmbH www.bode-chemie.de
Merck KGaA www.merck.de
Bayer AG www.bayer.de
Institutions:
Free and Hansestadt Hamburg http://fhh.hamburg.de/
Hamburger Sparkasse www.haspa.de
Hamburg Chamber of Commerce www.hk24.de
Innovationsstiftung Hamburg www.innovationsstiftung.de
Life Science Agentur Norgenta www.norgenta.de
Center of Competence Hansenanotec www.nanoscience.de/hansenanotec/
Center for Applied Nanotechnology (CAN) GmbH 32

32. CAN GmbH:
… get in contact !
Center for Applied Nanotechnology (CAN) GmbH
Grindelallee 117
20146 Hamburg
Germany
T +49 40 42838 – 4983
F +49 40 42838 – 5797
E fso@can-hamburg.de
www.can-hamburg.de
Center for Applied Nanotechnology (CAN) GmbH 33