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Gigantism

Table 4
Kevin Knox, Kaley Miller,
Hailey Ray, Ashley Spaulding
W, J. (2009, Janu 21). Double vision. Retrieved from http://www.jeffreymd.com/2009/01/31/double-vision/




       Symptoms
    • Pretty big people (usually two
      standard deviations above
      normal height should be)

    • Delayed puberty                                                                                     Vos, A., & Barnes, K.
                                                                                                          (2011). Gigantism.
                                                                                                          Retrieved from

    • Double vision or difficulty                                                                         http://misskay03.edu.gl
                                                                                                          ogster.com/gigantism
                                                                                                          /
      with side vision
                                                                                                               W, J. (2009, Janu
                                                                                                               21). Double vision.
                                                                                                               Retrieved from
                                                                                                               http://www.jeffrey
                                                                                                               md.com/2009/01/3
                                                                                                               1/double-vision/
•   Headaches
•   Increased sweating
•   Irregular periods (females)
•   Large hands and feet with
    large fingers and toes
• Release of breast milk
• Thickening of facial
  features
• Weakness
• Bulging forehead
Causes
• ***Excess of growth
  hormone ***(Acromegaly)
• Most commonly:
  Noncancerous(adenoma)
  tumor of the pituitary gland
• Carney complex
Possible solutions

• Medications that
  reduce growth
  hormone release
  such as somatostain
  analogs (growth
  inhibiting
  hormones)
• Dopamine agonoists
  but they are the
  least effective
Radiation
therapy can be
used to bring the
growth hormone
level back to
normal but it
take 5 to 10 years
to take full effect
and often effects
other pituitary
hormones
• Removal of tumor on pituitary through
  endonasal surgery (through nose)
Exams and Tests
• CT or MRI scans
-CT uses x-rays
-MRI uses magnets to align
  protons and take an MDM
  vector (fancy picture)
Exams and Tests
• CT or MRI scans
-CT uses x-rays
-MRI uses magnets to align
  protons and take an MDM
  vector (fancy picture)     CT


                  MRI
• Failure to suppress serum growth hormone
  (GH) levels after an oral glucose challenge
  (maximum 75g)

• Fancy way of saying they get you hopped up on
  sugar and see if your body can suppress growth
  hormone like a normal person would
Miscellaneous
• Female to male ratio
  of 1:2 (twice as
  common in males)
• Commonly occurs
  with Acromegaly
Fact Sources
• Eckman, S. (2009, 11 23). Gigantism. Retrieved from
  http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002157/
• Goyal, S. (n.d.). Gigantism. Retrieved from
  http://www.hxbenefit.com/gigantism-definition-symptoms-causes-
  treatment-and-acromegaly.html
• gigantism 2012. Encyclopædia Britannica Online School Edition.
  Retrieved 23 February 2012, from http://school.eb.com/eb/article-
  9036788
• drug. ( 2012). In Encyclopædia Britannica. Retrieved from
  http://school.eb.com/eb/article-10969
• Encyclopædia Britannica Online School Edition, s.v. "drug,"
  accessed February 23, 2012, http://school.eb.com/eb/article-10969.
• drug 2012. Encyclopædia Britannica Online School Edition.
  Retrieved 23 February 2012, from http://school.eb.com/eb/article-
  10969
• acromegaly. ( 2012). In Encyclopædia Britannica. Retrieved from
  http://school.eb.com/eb/article-9003588

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Gigantism

  • 1. Gigantism Table 4 Kevin Knox, Kaley Miller, Hailey Ray, Ashley Spaulding
  • 2. W, J. (2009, Janu 21). Double vision. Retrieved from http://www.jeffreymd.com/2009/01/31/double-vision/ Symptoms • Pretty big people (usually two standard deviations above normal height should be) • Delayed puberty Vos, A., & Barnes, K. (2011). Gigantism. Retrieved from • Double vision or difficulty http://misskay03.edu.gl ogster.com/gigantism / with side vision W, J. (2009, Janu 21). Double vision. Retrieved from http://www.jeffrey md.com/2009/01/3 1/double-vision/
  • 3. Headaches • Increased sweating • Irregular periods (females) • Large hands and feet with large fingers and toes
  • 4. • Release of breast milk • Thickening of facial features • Weakness • Bulging forehead
  • 5. Causes • ***Excess of growth hormone ***(Acromegaly) • Most commonly: Noncancerous(adenoma) tumor of the pituitary gland
  • 7. Possible solutions • Medications that reduce growth hormone release such as somatostain analogs (growth inhibiting hormones) • Dopamine agonoists but they are the least effective
  • 8. Radiation therapy can be used to bring the growth hormone level back to normal but it take 5 to 10 years to take full effect and often effects other pituitary hormones
  • 9. • Removal of tumor on pituitary through endonasal surgery (through nose)
  • 10. Exams and Tests • CT or MRI scans -CT uses x-rays -MRI uses magnets to align protons and take an MDM vector (fancy picture)
  • 11. Exams and Tests • CT or MRI scans -CT uses x-rays -MRI uses magnets to align protons and take an MDM vector (fancy picture) CT MRI
  • 12. • Failure to suppress serum growth hormone (GH) levels after an oral glucose challenge (maximum 75g) • Fancy way of saying they get you hopped up on sugar and see if your body can suppress growth hormone like a normal person would
  • 13. Miscellaneous • Female to male ratio of 1:2 (twice as common in males) • Commonly occurs with Acromegaly
  • 14. Fact Sources • Eckman, S. (2009, 11 23). Gigantism. Retrieved from http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002157/ • Goyal, S. (n.d.). Gigantism. Retrieved from http://www.hxbenefit.com/gigantism-definition-symptoms-causes- treatment-and-acromegaly.html • gigantism 2012. Encyclopædia Britannica Online School Edition. Retrieved 23 February 2012, from http://school.eb.com/eb/article- 9036788 • drug. ( 2012). In Encyclopædia Britannica. Retrieved from http://school.eb.com/eb/article-10969 • Encyclopædia Britannica Online School Edition, s.v. "drug," accessed February 23, 2012, http://school.eb.com/eb/article-10969. • drug 2012. Encyclopædia Britannica Online School Edition. Retrieved 23 February 2012, from http://school.eb.com/eb/article- 10969 • acromegaly. ( 2012). In Encyclopædia Britannica. Retrieved from http://school.eb.com/eb/article-9003588