Bordetella pertussis is a small, Gram-negative coccobacillus bacterium that causes whooping cough (pertussis). It produces several toxins, including pertussis toxin and adenylate cyclase toxin, which increase intracellular cAMP levels and disrupt cell signaling. Pertussis toxin also inhibits the immune response. B. pertussis colonizes the respiratory tract and causes a severe cough that often ends in a "whooping" sound. Whooping cough is highly contagious and prevents by vaccination.