2. DEFECTS IN LEUCOCYTE FUNCTION
GENETIC
• ADHESION DEFECTS-
• LAD1, LAD2
• INTEGRINS AND SELECTIN RECEPTORS DEFECTIVE
• REC BACTERIAL INFECTIONS AND IMPAIRED HEALING
• DEFECTS IN PHAGOLYSOSOME FUNCTION
• CHEDIAK HIGASHI SYN
• AR
• DEFECTIVE TRANSFER OF LYSOSOMAL ENZYMES
3.
4. DEFECTS IN LEUCOCYTE FUNCTION
• DEFECT IN MICROBICIDAL ACTIVITY
• CGD-DEFECTS IN NADPH OXIDASE
• REC BACTERIAL INFECTIONS
• MPO DEF
ACQUIRED-VARIOUS ASPECTS LIKE PHAGO,CHEMO ETC
AFFECTED
• DM
• MALIGNANCY
• MALNUTRITION
• ANEMIA
14. CHRONIC INFLAMMATION
• When inflammation can not be resolved
• In cases of
1. Persistence of agent
2. Interference with healing
15. MORPHOLOGICAL PATTERNS
• SEROUS
• THIN FLUID
• Eg BLISTER OF BURN
• FIBRINOUS
• MORE SEV INJURY
• FIBROGEN LEAKAGE CON TO FIBRIN
• LINING OF BODY CAVITIES-MENINGES,PERICARDIUM
• COR VILLOSUM/ BREAD AND BUTTER APP
• MICRO-EOSINOPHILIC MESHWORK
16. MORPHOLOGICAL PATTERNS
• SUPPURATIVE/ PURULENT
• SOME PYOGENIC BACTERIA
• LARGE AMTS OF PUS
• ABSCESS-LOCALIZED COLLECTION OF PUS WITHIN A
CAVITY
• ULCER
• LOCAL DEFECT IN SKIN OR MUCOSA
• Eg PEPTIC ULCER
20. PURULENT EXUDATE
• Exuded yellowish fluid
fluid in this opened
pericardial cavity also
contains a large number
of acute inflammatory
cells. So it is a purulent
exudate
21. SUPPURATIVE INFLAMMATION
A B
A: purulent exudate obscuring the sulci in pyogenic meningitis.
B: purulent peritonitis D/T rupture of the colon.
22. ABSCESS
• rounded abscesses (the
purulent material has
drained out after sectioning
to leave a cavity) in the
lung.
23. ABSCESS
• Diverticulitis of Colon
with abscess formation
Abscess
Sulfur granules of
actinomycoses
Lots of neutrophils
