DIYgenomics (www.DIYgenomics.org) is a new platform bringing citizen scientists together to run peer cohort research studies and conduct novel research linking genetic data and physical biomarkers. Some norms are developing in response to the variety of community-based research issues that arise such as adaptive studies, informed consent, security, anonymity, and study design.

1. Democratizing the Genome Melanie Swan Founder DIYgenomics +1-650-681-9482 @DIYgenomics www.DIYgenomics.org [email_address] June 12, 2010 H+ Summit, Harvard University Slides: http://slideshare.net/LaBlogga/slideshows

3. We are standing in a new era June 12, 2010 DIYgenomics.org 1999-2009: cost of DNA sequencing decreased 14,000x. April 1, 2010. Image credit: http://pubs.acs.org/cen/_img/87/i50/8750cover2_law.gif Dec. 14, 2009

4. A new construct of biocitizen identity June 12, 2010 DIYgenomics.org Source: Extended from Swan, M. Emerging patient-driven health care models: an examination of health social networks, consumer personalized medicine and quantified self-tracking. Int. J. Environ. Res. Public Health 2009 , 2, 492-525, Figure 1.

6. 3 rd and 4 th generation sequencing arrives June 12, 2010 DIYgenomics.org 3 rd Gen: Sequencing by Synthesis 2 nd Gen: Parallelized sequencing 1 st Gen: Sanger Sequencing 4 th Gen: Electronic Synthesis Sources: http://www.genomicseducation.ca/files/images/information_articles/sequencing.gif, http://www.wellcome.ac.uk/News/2009/Features/WTX056032.htm, http://www.pacificbiosciences.com/video_lg.html, http://www.nanoporetech.com/sequences

12. Thank you! Melanie Swan Founder DIYgenomics +1-650-681-9482 @DIYgenomics www.DIYgenomics.org [email_address] Slides: http://slideshare.net/LaBlogga/slideshows Creative Commons 3.0 license Collaborators: Raymond McCauley Lucymarie Mantese Marat Nepomnyashy Roland Parnaso Aaron Vollrath Lawrence S. Wong Crowd-sourced clinical trials Personal genome apps