1. CANCER: SOME CELLS DON'T
KNOW WHEN TO STOP AND DISCOVERY
OF NEW CLASS OF DAMAGE-PRONE
DNA REGIONS COULD LEAD TO BETTER
CANCER TREATMENTS
Laura Barrientos
Third semester
Medical student
2.
3.
4. INTRODUCTION
Central dogma of DNA replication:
genetic information:
In this
process a
DNA
molecule
Proteins synthesize a
DNA RNA new DNA
molecule
This process
occurs in the
phase S of
the cell cycle
This is important
because if there
is a
mistake, occurs a
mutation
5. CANCER: SOME CELLS DON'T KNOW WHEN TO
STOP
Cancer arises from
DNA damage in
fragile sites in the
genome, like
repetitive sequences.
6. CANCER: SOME CELLS DON'T KNOW WHEN TO
STOP
B cells lymphocytes are
the cells that have more The rason is because they
risk to have DNA damage. divide rapidly.
Also by the AID
7. CANCER: SOME CELLS DON'T KNOW WHEN TO
STOP
Early
replicating
frgile sites
(ERFSs) are
AID-
independient
ERFSs are
associeted
with the DNA
breaks.
ERFSs are
the principal
cause of
alteration in
B cells
lymphoma
8. CANCER: SOME CELLS DON'T KNOW WHEN TO
STOP
The replication of DNA
damage helps to adpat
and survive to the cells
when there is a
metastasis.
9. PEERSONAL COMMENT
This new is very importante
becuase now there is a better
knowledge about the
mechanism of the cancer, so
the scientists can improve
treatment and this will improve
the quality of life.
10. DISCOVERY OF NEW CLASS OF DAMAGE-PRONE DNA
REGIONS COULD LEAD TO BETTER CANCER TREATMENTS
Chemoterapy
drug stop DNA
replication in the
cancer cells
Some cells can
resist these
drugs.
11. DISCOVERY OF NEW CLASS OF DAMAGE-PRONE DNA
REGIONS COULD LEAD TO BETTER CANCER TREATMENTS
There are checkpoints
mutants that create
damaged DNA, this
can cause cancer
12. DISCOVERY OF NEW CLASS OF DAMAGE-PRONE DNA
REGIONS COULD LEAD TO BETTER CANCER TREATMENTS
Normally cells can
recognize when they loss
nucleotides, but
checkpoints mutants dont
recognize this signal.
13. DISCOVERY OF NEW CLASS OF DAMAGE-PRONE DNA
REGIONS COULD LEAD TO BETTER CANCER TREATMENTS
Some cells
continue with
the replication of
damaged DNA.
There is a
collapse
point where
strands
break.
14. PERSONAL COMMENT
With this investigation
scientists know what
are the failures in the
treatment, and other
cause of cancer. So
now they can create
other methods to
trear this disease.
15. MEDICAL BENEFIT
With these
knowledges the
cancer´s treatment
can improve, and
this probably will
save many lifes.
16. MEDICAL BENEFIT
In cancer and helthy
cells we can find
problems in the
replication, so now
scientists must to
create methods to
control and supervise
these problems.
17. MEDICAL BENEFIT
Scientists can
create a method
to identify which
cells have
problems in the
replication, and
the way to stop
them.
18. MEDICAL BENEFIT
To understand the
consequences of the
chemotherapy, and
know why this can
not traet cancer by
100%, but this can
improve it.
19. BIBLIOGRAPHY
Martínez S, Lina Maria. Biología Molecular. 5 ed
Medellín: UPB. Facultad Medicina.
Cancer: Some Cells Don't Know When to Stop.
Science Daily. November 19, 2012
Discovery of New Class of Damage-Prone DNA
Regions Could Lead to Better Cancer Treatments.
Science Daily. January 24
