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Wirkung von Vitamin D
bei Krebserkrankungen
Stefan Pilz
Department of Internal Medicine, Division of Endocrinology and
Metabolism, Medical University of Graz, Austria
Department of Epidemiology and Biostatistics, EMGO Institute for Health
and Care Research, VU University Amsterdam, The Netherlands
OUTLINE
Vitamin D and sun

Reichrath J. British Journal of Dermatology, 2009; 161: 54-60
Cancer and sunlight

Apperly FL
Cancer Res 1:191-195, 1941
Cancer and sunlight

Apperly FL. Cancer Res 1:191-195, 1941
Solar radiation and colon cancer

Int J Epidemiol 1980; 9:227-231
UV-B and cancer mortality

Cancer 2002;94:1867-1875
OUTLINE
Vitamin D and melanoma
Vitamin D and melanoma
Vitamin D and cancer

47,800 men
4,286 incident cancers
2,025 cancer deaths
Largest study in this field
Vitamin D and cancer mortality

Data from 3299 patients referred for coronary angiography and followed up for 7.7 years

Cumulative Survival

1.00
0.99

HR 0.49 (0.28-0.88)
0.98

(fully adjusted model)

0.97
25-hydroxyvitamin D (ng/ml)

0.96

Q1 (Low)
Q2
Q3
Q4 (High)

0.95
0.94
0

2

4

6

8

10

(N=95)

Follow-up (years)
Pilz S et al, Cancer Epidemiol Biomarkers Prev 2008; 17: 1228-1233
Vitamin D and colorectal cancer

Non-linear dose-response metaanalyses on circulating 25hydroxyvitamin D and risk of
colorectal cancer
Vitamin D and colorectal cancer

Dose-response meta-analyses of total (dietary + supplemental) vitamin D
intake and risk of colorectal and colon cancer
OUTLINE
Anticancer effects of vitamin D

684-700
Anticancer effects of vitamin D

JNCI J Natl Cancer Inst
(1992) 84(17): 1355-1357
OUTLINE
Vitamin D and cancer incidence

A 4-year, population based, double-blind, randomized, placebo
controlled trial among healthy postmenopausal women (n=1179)
receiving 1400-1500 mg calcium/d (Ca-only), calcium plus 1100 IU
vitamin D/d (Ca + D), or placebo
Entire study cohort

Free of cancer at 1 years of intervention

RR 0.23***

RR 0.40**

** P=0.01

*** P=0.005
Lappe J, et al. Am J Clin Nutr 2007;85:1586-91
WHI-Study
WHI-Study
OUTLINE
Conclusion

Sunlight (ultraviolet-B exposure), which increases vitamin D synthesis
in the skin, is associated with reduced cancer risk
Vitamin D exerts various anti-carcinogenic effects
Observational and interventional studies have partially but not
consistently shown an association of a poor vitamin D status
with increased cancer risk
Whether vitamin D supplementation is effective in the
prevention and treatment of cancer remains to be further
evaluated in large-scale randomized controlled trials but the
promising data on vitamin D regarding cancer and various other
health outcomes strongly argue that it is reasonable to prevent
and treat vitamin D deficiency
Thank you for your attention !

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Stefan Pilz - Vitamin D und Krebs

  • 1. Wirkung von Vitamin D bei Krebserkrankungen Stefan Pilz Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University of Graz, Austria Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Amsterdam, The Netherlands
  • 3. Vitamin D and sun Reichrath J. British Journal of Dermatology, 2009; 161: 54-60
  • 4. Cancer and sunlight Apperly FL Cancer Res 1:191-195, 1941
  • 5. Cancer and sunlight Apperly FL. Cancer Res 1:191-195, 1941
  • 6. Solar radiation and colon cancer Int J Epidemiol 1980; 9:227-231
  • 7. UV-B and cancer mortality Cancer 2002;94:1867-1875
  • 9. Vitamin D and melanoma
  • 10. Vitamin D and melanoma
  • 11. Vitamin D and cancer 47,800 men 4,286 incident cancers 2,025 cancer deaths Largest study in this field
  • 12. Vitamin D and cancer mortality Data from 3299 patients referred for coronary angiography and followed up for 7.7 years Cumulative Survival 1.00 0.99 HR 0.49 (0.28-0.88) 0.98 (fully adjusted model) 0.97 25-hydroxyvitamin D (ng/ml) 0.96 Q1 (Low) Q2 Q3 Q4 (High) 0.95 0.94 0 2 4 6 8 10 (N=95) Follow-up (years) Pilz S et al, Cancer Epidemiol Biomarkers Prev 2008; 17: 1228-1233
  • 13. Vitamin D and colorectal cancer Non-linear dose-response metaanalyses on circulating 25hydroxyvitamin D and risk of colorectal cancer
  • 14. Vitamin D and colorectal cancer Dose-response meta-analyses of total (dietary + supplemental) vitamin D intake and risk of colorectal and colon cancer
  • 16. Anticancer effects of vitamin D 684-700
  • 17.
  • 18.
  • 19. Anticancer effects of vitamin D JNCI J Natl Cancer Inst (1992) 84(17): 1355-1357
  • 21. Vitamin D and cancer incidence A 4-year, population based, double-blind, randomized, placebo controlled trial among healthy postmenopausal women (n=1179) receiving 1400-1500 mg calcium/d (Ca-only), calcium plus 1100 IU vitamin D/d (Ca + D), or placebo Entire study cohort Free of cancer at 1 years of intervention RR 0.23*** RR 0.40** ** P=0.01 *** P=0.005 Lappe J, et al. Am J Clin Nutr 2007;85:1586-91
  • 22.
  • 23.
  • 27.
  • 28. Conclusion Sunlight (ultraviolet-B exposure), which increases vitamin D synthesis in the skin, is associated with reduced cancer risk Vitamin D exerts various anti-carcinogenic effects Observational and interventional studies have partially but not consistently shown an association of a poor vitamin D status with increased cancer risk Whether vitamin D supplementation is effective in the prevention and treatment of cancer remains to be further evaluated in large-scale randomized controlled trials but the promising data on vitamin D regarding cancer and various other health outcomes strongly argue that it is reasonable to prevent and treat vitamin D deficiency
  • 29.
  • 30. Thank you for your attention !