Prof. Dr. Stefan Pilz: Sonne, Sonnenschein-Vitamin D und Krebs. Forschungsergebnisse zu Vitamin D und seine Wirkung bei Prävention und Therapie verschiedener Krebsarten. Vortrag beim "Vitamin D-Update 2013" in der Charité Berlin
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Stefan Pilz - Vitamin D und Krebs
1. Wirkung von Vitamin D
bei Krebserkrankungen
Stefan Pilz
Department of Internal Medicine, Division of Endocrinology and
Metabolism, Medical University of Graz, Austria
Department of Epidemiology and Biostatistics, EMGO Institute for Health
and Care Research, VU University Amsterdam, The Netherlands
11. Vitamin D and cancer
47,800 men
4,286 incident cancers
2,025 cancer deaths
Largest study in this field
12. Vitamin D and cancer mortality
Data from 3299 patients referred for coronary angiography and followed up for 7.7 years
Cumulative Survival
1.00
0.99
HR 0.49 (0.28-0.88)
0.98
(fully adjusted model)
0.97
25-hydroxyvitamin D (ng/ml)
0.96
Q1 (Low)
Q2
Q3
Q4 (High)
0.95
0.94
0
2
4
6
8
10
(N=95)
Follow-up (years)
Pilz S et al, Cancer Epidemiol Biomarkers Prev 2008; 17: 1228-1233
13. Vitamin D and colorectal cancer
Non-linear dose-response metaanalyses on circulating 25hydroxyvitamin D and risk of
colorectal cancer
14. Vitamin D and colorectal cancer
Dose-response meta-analyses of total (dietary + supplemental) vitamin D
intake and risk of colorectal and colon cancer
21. Vitamin D and cancer incidence
A 4-year, population based, double-blind, randomized, placebo
controlled trial among healthy postmenopausal women (n=1179)
receiving 1400-1500 mg calcium/d (Ca-only), calcium plus 1100 IU
vitamin D/d (Ca + D), or placebo
Entire study cohort
Free of cancer at 1 years of intervention
RR 0.23***
RR 0.40**
** P=0.01
*** P=0.005
Lappe J, et al. Am J Clin Nutr 2007;85:1586-91
28. Conclusion
Sunlight (ultraviolet-B exposure), which increases vitamin D synthesis
in the skin, is associated with reduced cancer risk
Vitamin D exerts various anti-carcinogenic effects
Observational and interventional studies have partially but not
consistently shown an association of a poor vitamin D status
with increased cancer risk
Whether vitamin D supplementation is effective in the
prevention and treatment of cancer remains to be further
evaluated in large-scale randomized controlled trials but the
promising data on vitamin D regarding cancer and various other
health outcomes strongly argue that it is reasonable to prevent
and treat vitamin D deficiency