1. Monday, June 18, 2012

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Monday, June 18, 2012

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Monday, June 18, 2012

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Monday, June 18, 2012

5. BIOLOGY 151
(INTRODUCTION TO IMMUNOLOGY)
1. Orientation
2. Overview of Immunology
a. History of Immunology & Famous
Personalities
b. General Properties & Components of the
Immune System
Monday, June 18, 2012

6. ORIENTATION
COURSE DESCRIPTION: Structure and Function of the
Immune System; Antigen-Antibody Reactions; Genetic
Control of the Immune System and Basic Immunological
Techniques
COURSE CREDIT: 3 units (2 units lecture and 1 unit
laboratory)
PREREQUISITES: Biology 10, 21, 22; Chemistry 40 and
40.1
Monday, June 18, 2012

7. ORIENTATION
Monday, June 18, 2012

8. ORIENTATION
COURSE OBJECTIVES
Monday, June 18, 2012

9. ORIENTATION
COURSE OBJECTIVES
Describe and differentiate the general properties and components of the
immune system with focus on antigens and antibodies;
Monday, June 18, 2012

10. ORIENTATION
COURSE OBJECTIVES
Describe and differentiate the general properties and components of the
immune system with focus on antigens and antibodies;
Distinguish and compare innate and adaptive immune responses of the
body during a pathogenic or non-pathogenic challenge;
Monday, June 18, 2012

11. ORIENTATION
COURSE OBJECTIVES
Describe and differentiate the general properties and components of the
immune system with focus on antigens and antibodies;
Distinguish and compare innate and adaptive immune responses of the
body during a pathogenic or non-pathogenic challenge;
Recognize and demonstrate which diagnostic procedures will best detect
antigens and antibodies;
Monday, June 18, 2012

12. ORIENTATION
COURSE OBJECTIVES
Describe and differentiate the general properties and components of the
immune system with focus on antigens and antibodies;
Distinguish and compare innate and adaptive immune responses of the
body during a pathogenic or non-pathogenic challenge;
Recognize and demonstrate which diagnostic procedures will best detect
antigens and antibodies;
Be familiar with the mechanisms of the different immunodeficiencies;
Monday, June 18, 2012

13. ORIENTATION
COURSE OBJECTIVES
Describe and differentiate the general properties and components of the
immune system with focus on antigens and antibodies;
Distinguish and compare innate and adaptive immune responses of the
body during a pathogenic or non-pathogenic challenge;
Recognize and demonstrate which diagnostic procedures will best detect
antigens and antibodies;
Be familiar with the mechanisms of the different immunodeficiencies;
Define and differentiate the types of vaccines and their uses; and
Monday, June 18, 2012

14. ORIENTATION
COURSE OBJECTIVES
Describe and differentiate the general properties and components of the
immune system with focus on antigens and antibodies;
Distinguish and compare innate and adaptive immune responses of the
body during a pathogenic or non-pathogenic challenge;
Recognize and demonstrate which diagnostic procedures will best detect
antigens and antibodies;
Be familiar with the mechanisms of the different immunodeficiencies;
Define and differentiate the types of vaccines and their uses; and
Determine the ethical considerations in the study and applications of
Immunology in research
Monday, June 18, 2012

15. CALENDAR OF ACTIVITIES
DATE ACTIVITY
June 19 (2 hours) ORIENTATION & OVERVIEW OF IMMUNOLOGY
History of Immunology and Famous Personalities
General properties and components: the cells and their function
June 26 (2 hours) ANTIGENS AND ANTIBODIES
July 3-10 (4 hours) INNATE & ADAPTIVE IMMUNITY
July 17-24 (4 hours) HUMORAL & CELLULAR IMMUNITY
July 31 EXAMINATION 1
EXAM 1: JULY 31, 2012
August 7 (2 hours) PATHOGENESIS OF BACTERIAL INFECTIONS
a. Immunity to bacteria
b. Important bacterial infections
c. Serological diagnosis to detect antigens and antibodies
August 14 (2 hours) PATHOGENESIS OF VIRAL INFECTIONS
a. Immunity to viruses
b. Important viral infections
c. Serological diagnosis to detect antigens and antibodies
August 21-24 BIOWEEK CELEBRATION: CLASS POSTER PRESENTATION
August 28 (2 hours) PATHOGENESIS OF FUNGAL INFECTIONS
a. Immunity to fungi
b. Important fungal infections
c. Serological diagnosis to detect antigens and antibodies
September 4 (2 hours) PATHOGENESIS OF PARASITIC INFECTIONS
a. Immunity to parasites
b. Important parasitic infections
c. Serological diagnosis to detect antigens and antibodies
September 11 EXAMINATION 2
EXAM 2: SEPT 11, 2012
September 18 ( 2hours) IMMUNODEFICIENCIES
a. Immunologic tolerance and hypersensitivities
b. Selected immunodeficiencies (e.g. HIV, etc)
VACCINES
a. types of vaccines and their design
b. Philippine laws on vaccination
c. vaccine challenges
September 25 CLASS PLENARY REPORT: VACCINE CHALLENGES (HIV, pandemics, vector-
borne or zoonotic diseases) EXAM 3: OCT 2, 2012
October 2 EXAMINATION 3
Monday, June 18, 2012

16. COURSE REQUIREMENT
A. Lecture (60%) B. Laboratory (40%)
Lecture exams (3)!! 60% Laboratory exams (2)!
! 50%
Quizzes! ! ! 20% Laboratory reports! ! 10%
Plenary Report!
! 20% Journal report! ! ! 10%
Quizzes! ! ! 10%
Laboratory performance! 10%
Monday, June 18, 2012

17. EXAMS & QUIZZES
EXAMS
sit-down, written exam; class hours
objective and critical thinking type
QUIZZES
individual, pair, group, class quizzes
written, oral or take-home
no make-up for missed quizzes!
Monday, June 18, 2012

18. CLASS plenary
CONFERENCE-TYPE OF PAPER
PRESENTATIONS
3 PAPERS: VACCINE CHALLENGES (HIV,
pandemics, vector-borne or zoonotic diseases)
TASKS: Speakers, Master of Ceremonies,
Moderator, Reactors, Technical Group, Logistics
Group, Refreshments Group, Press Group, etc
CLASS GRADE: Absent during the presentation
is given a ZERO (0) mark
Monday, June 18, 2012

19. your grade
PFG = lecture (60%) + laboratory (40%) rating
NOTE: This will be the final grade when
exempted to take the final exams.
If the student will take the finals the rating will
be computed as follows, which should be no
lower than 60% or 3.0:
RATING = PFG (80%) + Score in Finals
Exam (20%)
Monday, June 18, 2012

20. OUR TEXTBOOK
Abbas, Abul K. and
Andrew H. Lichtman.
2004. Basic
Immunology: Function
and Disorders of the
Immune System. 2nd ed.
Monday, June 18, 2012

21. POLICIES
The student should be able to pass (PFG = 3.0) both lecture and
laboratory component to pass the course
There will be no make-up exams, missed exams will qualify
students to take the final examination. The score in the final
exam may replace the missed exam. However, in the case of
two missed exams, the other exam will have a score of zero (0)
The student should be able to incur a PFG of 2.0 or better to be
exempted to take the written final exam
Should the student fail the final exam, an oral removal exam to
satisfy the course competencies will be given to pass the course.
The grade to be given here shall only be a “pass” (3.0) or
“fail” (5.0)
Monday, June 18, 2012

22. QUESTIONS???
Monday, June 18, 2012

23. RECALL from BIOLOGY 120
THE WAR WITH
MICROBES...
Monday, June 18, 2012

24. HOW WE FIGHT
INFECTIONS...
www.youtube.com/watch?v=T_4TrNRa3v8
Monday, June 18, 2012

25. TODAY....
Looking back.........
famous personalities
how it all started
Who’s who of our immune system...
cells
general functions
Monday, June 18, 2012

26. Monday, June 18, 2012

27. Monday, June 18, 2012

28. International Journal of Infectious Diseases
Volume 3, Issue 1, July-September 1998, Pages 54-60
Monday, June 18, 2012

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37. ! ▪! 2001 – Discovery of FOXP3 – the gene directing regulatory T cell development
! ▪! 2005 – Development of human papillomavirus vaccine (Ian Frazer)
Monday, June 18, 2012

38. CELLS & ORGANS OF THE
IMMUNE SYSTEM
Monday, June 18, 2012

39. INNATE
HUMORAL
complement system
CELLULAR
monocytes (macrophages, dendritic cells)
NKC (natural killer cells)
granulocytes (mast cells and , basophils,
eosinophils, neutrophils)
Monday, June 18, 2012

40. Monday, June 18, 2012

41. Monday, June 18, 2012

42. Monday, June 18, 2012

43. ADAPTIVE
HUMORAL
antibodies
complement system
CELLULAR
B cells
T cells
Monday, June 18, 2012

44. Monday, June 18, 2012

45. organs of the immune system
Monday, June 18, 2012

46. MUST KNOW...
ANTIGEN
ANTIBODIES
Monday, June 18, 2012

47. OJT: IMMUNE CELLS
Monday, June 18, 2012

48. OJT: IMMUNE CELLS
Monday, June 18, 2012

49. OUR IMMUNE SYSTEM
Physiologic function of the immune system:
prevent infections
eradicate established infections
Monday, June 18, 2012

50. OUR IMMUNE SYSTEM
vaccines: stimulation of our Immune System
Monday, June 18, 2012

51. overview: host defense
mechanisms
INNATE: immunity which mediates the initial protection against
infections
always present in health individuals
block the entry of microbes and rapidly eliminate microbes that do
succeed in entering host tissues
ADAPTIVE: immunity which!develop more slowly and mediates innate
immunity
more effective defense against infections
specific or acquired
stimulated by microbes that invade tissues
adapts to the presence of microbial invaders
Monday, June 18, 2012

52. overview: host defense
mechanisms
Monday, June 18, 2012

53. Monday, June 18, 2012

54. OVERVIEW: HUMORAL & CELL-
MEDIATED IMMUNITY
Monday, June 18, 2012

55. NOTE: ADAPTIVE RESPONSE
Immunity may be induced in an individual by infection or
vaccination (active immunity) or conferred on an individual by
transfer of antibodies or lymphocytes from an actively immunized
individual (passive immunity)
Monday, June 18, 2012

56. SPECIFICITY & MEMORY
Monday, June 18, 2012

57. OVERVIEW: PHASES OF ADAPTIVE
IMMUNITY
Monday, June 18, 2012

58. MAJOR CHARACTERS OF THE
IMMUNE SYSTEM
Monday, June 18, 2012

59. THE EFFECTOR FUNCTIONS
Monday, June 18, 2012

60. When naive lymphocytes
recognize microbial antigens
and also receive additional
("second) signals induced by
microbes, the antigen-specific
lymphocytes proliferate and
differentiate into effector
cells and memory cells
Naive lymphocytes express
receptors for antigens but do
not perform the functions that
are required to eliminate
antigens
Differentiation into effector
cells and memory cells is
initiated by antigen
recognition, thus ensuring that
the immune response that
develops is specific for the
antigen
Monday, June 18, 2012

61. END OF LECTURE 1
Monday, June 18, 2012