Material Safety Data Sheet (MSDS) for Cosmesome-Res (NE) a Proliposome formulation manufactured by Encapsula NanoSciences that is used specifically in the cosmetic industry. The brand name is Cosmesome-Res (NE). The Cosmesome-Res (NE) formulation is composed of saturated phospholipids and it does not contain alcohol. The proliposome formulation forms liposomes containing resveratrol upon dilution with water. During the dilution process water soluble active ingredients can be encapsulated inside the liposomes or liposoluble active ingredients can be incorporated into the lipid bilayers.

1. Material Safety Data Sheet
Version 1.1
Revision Date: 06/05/2014
Print Date: 08/06/2014
1. PRODUCT AND COMPANY IDENTIFICATION
Product name: COSMESOME TM- Res (NE)
Product Number: COS-1009
Brand: COSMESOME TM
Company Address: ENCAPSULA NANOSCIENCES LLC
6 CADILLAC DRIVE SUITE 245
BRENTWOOD, TN, 37027
Technical Phone: 615-884-4442
Fax: 615-250-8747
Emergency Phone: 615-438-8553
CHEMTREC: 1-800-424-9300
2. COMPOSITION/INFORMATION ON INGREDIENTS
Ingredient Name CAS# Percent
WATER 7732-18-5 >90
GLYCERIN 56-81-5
1, 3 Butanediol 107-88-0 <5
3,5,4-TRIHYHROXY-TRANS-STILBENE 501-36-0
L-α-PHOSPHATIDYLCHOLINE, hydrogenated 97281-48-6 <5
3. HAZARDS IDENTIFCATION
OSHA
No known OSHA hazards
TARGET ORGANS
Skin, Respiratory, Eyes
WHMIS HAZARD CLASS
D1B toxic materials
D2B toxic materials
HMIS RATING
HEALTH HAZARDS: 1
FLAMMABILITY: 1
CHRONIC HEALTH HAZARDS: *
PHYSICAL HAZARDS: 0

2. Material Safety Data Sheet
Version 1.1
Revision Date: 06/05/2014
Print Date: 08/06/2014
NFPA RATING
HEALTH HAZARD: 2
FLAMMABILTY: 1
REACTIVITY: 0
POTENTIAL HEALTH EFFECTS
Inhalation May be harmful if inhaled.
Skin May be harmful if absorbed through skin
Eyes May cause eye irritation.
Ingestion May be harmful if swallowed.
Chronic No existing conditions have been investigated
4. FIRST AID MEASURES
ORAL EXPOSURE
Do not induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with
water. Consult a physician
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give
oxygen. Do not use mouth to mouth resuscitation. Consult a physician.
DERMAL EXPOSURE
In case of contact, immediately wash skin with soap and copious amounts of water. Cover skin with
an emollient. Contact a physician.
EYE EXPOSURE
In case of contact, check or remove any contact lenses; immediately flush eyes with copious amounts
of water for at least 15 minutes. Contact a physician.
5. FIRE FIGHTING MEASURES
FLAMMABILITY
Not available
EXTINGUISHING MEDIA
It is suitable to use water spray, alcohol -resistant foam, dry chemical or carbon dioxide.

3. Material Safety Data Sheet
Version 1.1
Revision Date: 06/05/2014
Print Date: 08/06/2014
SPECIAL PROCTECTIVE EQUIPMENT FOR FIRE-FIGHTERS
Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and
eyes. Included a positive pressure NIOSH approved self-contained breathing apparatus.
HAZARDOUS COMBUSTION PRODUCTS
Carbon oxides
SPECIAL REMARKS
Not available
ACCIDENTAL RELEASE MEASURES
METHODS FOR CLEANING UP
Soak up inert absorbent material and dispose of as waste. Keep in suitable container for disposal.
Use appropriate tools to put this spilled solid in a convenient waste disposable container and finish
cleaning by spreading water on the contaminated surface and dispose of according to local and
region authority requirements. Allow to evacuate through the sanitary system
ENVIRONMENTAL PRECAUTIONS
Do not let product enter drains. If safe to do so prevent further leakages or spills.
PERSONAL PRECAUTIONS
Use personal protective equipment. Avoid breathing in vapors, mist or gas. Ensure adequate
ventilation. Prepare evacuation sites.
6. HANDLING AND STORAGE
HANDLING
User Exposure: Do not breathe vapor, dust, fume, gas, mist and spray. Avoid prolonged or repeated
exposure. Do not get in eyes, on skin, on clothing. Wash hands thoroughly after handling.
STORAGE
Suitable: Keep tightly container closed. Store in temperature between approximately 2-8 o C. Do not
freeze keep in refrigerator. Product is sensitive to moisture and light. Keep product and empty
container away from heat and sources ignition.
7. EXPOSURE CONTROLS/ PERSONAL PROTECTION
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.

4. Material Safety Data Sheet
Version 1.1
Revision Date: 06/05/2014
Print Date: 08/06/2014
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Use respirators and components tested and approved under appropriate government
standards such as NIOSH (US) in accord with 29 CFR 1910.134 or EN 149, use either an atmosphere
supply respirator or air purifying respirator. Also follow face protection regulations in 29 CFR
1910.133 or European standard EN 166. Also use a full -face respirator with multi -purpose
combination (US) or type ABEK (EN 14387) respirator cartridges as a back up to engineering
controls. If the respirator is the sole means of protection, use a full -face supplied airs respirator.
Use respirators and components tested and approved under appropriate government standers
such as NIOSH (US) or CEN (EU).
Hand: Compatible chemical -resistant gloves.
Eye: Chemical safety goggles. Safety glasses with side-shields conforming to EN 166 use equipment
for eye protection listed and approved under appropriated government standards such as NIOSH
(US) or EN166 (EU)
Skin and Body: Wear a complete suit protecting against chemicals.
GENERAL HYGIENE MEASURES
Wash hands thoroughly after handling. Wash contaminated clothing before reuse. Prepare all
materials under the fume hood and avoid generating aerosols.
8. PHYSICAL AND CHEMICAL PROPERTIES
Appearance
white, viscous liquid
Safety data
N/A
Melting point
N/A
Boiling point
N/A
Flash point
N/A
Ignition Temperature
N/A
Lower explosion limit
N/A
Upper Explosion limit
N/A
Water Solubility
N/A

5. Material Safety Data Sheet
Version 1.1
Revision Date: 06/05/2014
Print Date: 08/06/2014
Density
N/A
9. STABILITY AND REACITIVITY
STORAGE STABILITY
Store under recommended conditions.
MATERIALS TO AVIOD
Strong oxidizing agents, strong acids
HAZARDOUS DECOMPOSITION PRODUCTS
N/A
CONDITIONS TO AVOID
Light and exposure to moisture. Strong bases and Strong oxidizing agents.
10. TOXICOLOGICAL INFORMATION
CARCINOGENICITY
This product contains a component that has been reported to be carcinogenic based on its IARC, OHSA, ACGIH,
NTP, or EPA classification.
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by the IARC.
OHSA: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by the OHSA.
ACGIH: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by the ACGIH.
EPA: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by the EPA.
CHRONIC.
Only select Regeristory or Toxic of Chemical Substances (RTECS) data as presented here. See
actual entery RTECS for complete information. Product is harmful by ingestion.
Repeated contact may cause allergic reactions in very susceptible persons.
ACUTE TOXICITY
1,3-Butanediol : Oral LD50- mouse rat-698 mg/kg
Symptoms: Sense organs and special senses (eye-lacrimation; muscle weakness; diarrhea)
Dermal LD50- rabbit >20,000 mg/kg
Glycerin: Oral LD50- mouse rat-698 mg/kg

6. Material Safety Data Sheet
Version 1.1
Revision Date: 06/05/2014
Print Date: 08/06/2014
Symptoms: Sense organs and special senses (eye-lacrimation; muscle weakness; diarrhea)
Dermal LD50- rabbit >20,000 mg/kg
ADDITIONAL INFORMATION
Prolonged or repeated exposure may result in Nausea, Headache, or Vomiting
Kidney- irregularities-based on Human evidence
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation. May produce an allergic reaction.
Skin Absorption: May be harmful if absorbed through the skin
Eye Contact: May Cause eye irritation and risk serious damage
Inhalation: Materials may be irritating to mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed. Ingestion may cause gastrointestinal irritation,
nausea, vomiting and diarrhea.
SIGNS AND SYMPTOMS OF EXPOSURE
Symptoms have not be thoroughly investigated
11. ECOLOGICAL INFORMATION
Elimination information (persistence and degradability)
N/A
Ecotoxicity effects
N/A
Further information on ecology
N/A
12. DISPOSAL CONSIDERATIONS
PRODUCT
Observe all federal, state, and local environment regulations. Contact a licensed professional waste
disposal service to remove this material .
CONTAMINATED PACKAGING
Observe all federal, state, and local environment regulations.
13. TRANSPROT INFORMATION
DOT (US)
Not dangerous goods

7. Material Safety Data Sheet
Version 1.1
Revision Date: 06/05/2014
Print Date: 08/06/2014
IMDG
Not dangerous goods
IATA
Not dangerous goods
15. REGULATORY INFORMATION
OSHA HAZARDS
OSHA: Hazardous by definition of Hazard Communication Standard (29 SFR 1910.1200). EINECS:
this product is on the European Inventory of Existing Commercial Chemical Substances
SARA 302 COMPONENTS
SARA 302: No chemicals in this material are subject to the reporting requirements of SARA Title
III, Section 302
SARA 313 COMPONENTS
SARA 313: This material does not contain any chemical components with known CAS numbers
that exceed threshold (De Minimis) reporting levels establi shed be SARA Title III, Section 313
SARA 311/312 HAZARDS
Acute health hazards, chronic health hazards , fire hazard
MASSACHUSETTS RIGHT TO KNOW COMPONENTS
CAS-No. Revision Date
Glycerol 56-81-5 2007-03-01
PENNSYVANIA RIGHT TO KNOW COMPONENTS
CAS-No. Revision Date
L-α-PHOSPHATIDYLCHOLINE, hydrogenated 97281-48-6 1989-08-11
Glycerol 56-81-5 2007-03-01
Butane-1,3-diol 107-88-0
Water 7732-18-5
Resveratrol 501-36-0
NEW JERSEY RIGHT TO KNOW COMPONENTS
CAS-No. Revision Date
L-α-PHOSPHATIDYLCHOLINE, hydrogenated 97281-48-6 1989-08-11
Glycerol 56-81-5 2007-03-01
Butane-1,3-diol 107-88-0
Water 7732-18-5
Resveratrol 501-36-0

8. Material Safety Data Sheet
Version 1.1
Revision Date: 06/05/2014
Print Date: 08/06/2014
CALIFORNIA PROP. 65 COMPONENTS
CAS-No. Revision Date
L-α-PHOSPHATIDYLCHOLINE, hydrogenated 97281-48-6 1989-08-11
U.S Department of Homeland Security
This product does not contain any DHS chemicals
Canada
This product has been classified in accordance with the hazard criteria of the Controlled Products
Regulation (CPR) and the MSDS contains all the information required by the CPR.
CAS# 7732185 is listed on Canada's DSL List
TSCA
CAS# 7732185 is listed on the TSCA Inventory
16. OTHER INFORMATION
Copyright 2013 Encapsula NanoSciences LLC license granted to make unlimited paper copies for internal
use only.
The above information is believed to be correct but does not support to be all inclusive and shall be used
only as a guide. The information in this document is based on the present state of our knowledge and is
applicable to the product with regard to appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Encapsula NanoSciences LLC shall not be held liable for any
damage resulting from handling or from contact with the above product.