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Bacterial infectious diseases:  The PG perspective Ivo G Boneca Group Biology and genetics of the bacterial cell wall Institut Pasteur, INSERM Paris, France CEA CHRU CNRS CPU INRA INRIA INSERM INSTITUT PASTEUR IRD
PG a key component of bacterial physiology peptidoglycan Bacterial shape/  physiology Antibiotics  resistance Host/Microbe interactions Mesenteric  Lymph Nodes Peyer’s Patches Cryptopatches Lymphatics ILFs Gram -
Understanding PG structure and assembly How do they work ? How do they determine shape? Model PBP2 MreC SID 116 226 PBP2 (588 aa) N-ter C-ter MreC (248 aa)
Can the SID peptide be used as an inhibitor ? ,[object Object],[object Object],SID 116 226 PBP2 (588 aa) N-ter C-ter MreC  (248 aa) SP TAT  +SID
PG is a signaling molecule Homeostasis  Disease  M A G G M A G G dA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Girardin et al. 2003.  J. Biol. Chem . 278(11):8869-72 Girardin et al. 2003.  J. Biol. Chem . 278(43):41702-8 Girardin et al. 2003.  Science . 300(5625):1584-7 Nod1 Nod2 NF-kB JNK MAMP Intracellular Nod1
Understanding PG as a signaling molecule Analysis of the H ost response DNA arrays  Fine analysis of  PG  distribution Structural analysis of circulating  3 H- PG by HPLC  Analysis of circulating cells carrying  3 H- PG by AutoMACs  Soluble  3 H-PG Homeostasis  vs Disease (IBD, sepsis)
Studying the PG as a signaling molecule  in vivo time 24 h Femur (0.02 cpm/mm 2 )  Stomach (0.24 cpm/mm 2 )  Intestin (0.08 cpm/mm 2 )  1 h 6 h
Perspectives ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
peptidoglycan Bacterial shape/  physiology Antibiotics  resistance Host/Microbe interactions

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1.2 ivo boneca

  • 1. Bacterial infectious diseases: The PG perspective Ivo G Boneca Group Biology and genetics of the bacterial cell wall Institut Pasteur, INSERM Paris, France CEA CHRU CNRS CPU INRA INRIA INSERM INSTITUT PASTEUR IRD
  • 2. PG a key component of bacterial physiology peptidoglycan Bacterial shape/ physiology Antibiotics resistance Host/Microbe interactions Mesenteric Lymph Nodes Peyer’s Patches Cryptopatches Lymphatics ILFs Gram -
  • 3. Understanding PG structure and assembly How do they work ? How do they determine shape? Model PBP2 MreC SID 116 226 PBP2 (588 aa) N-ter C-ter MreC (248 aa)
  • 4.
  • 5.
  • 6. Understanding PG as a signaling molecule Analysis of the H ost response DNA arrays Fine analysis of PG distribution Structural analysis of circulating 3 H- PG by HPLC Analysis of circulating cells carrying 3 H- PG by AutoMACs Soluble 3 H-PG Homeostasis vs Disease (IBD, sepsis)
  • 7. Studying the PG as a signaling molecule in vivo time 24 h Femur (0.02 cpm/mm 2 ) Stomach (0.24 cpm/mm 2 ) Intestin (0.08 cpm/mm 2 ) 1 h 6 h
  • 8.
  • 9. peptidoglycan Bacterial shape/ physiology Antibiotics resistance Host/Microbe interactions