GlaxoSmithKline (GSK) is one of the world’s largest research based pharmaceutical corporation that discover, develops, manufactures and markets branded health care products. GSK mission is to improve the quality of human life by enabling people to do more, feel better and live longer

1. Influenza Virus Vaccine
Presented by: Mahak Ajmera

2. Contents
Company Introduction
Health Care Portfolio
Influenza Virus
Products
Vaccine Development Process
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3. GlaxoSmithKline
World largest research based
pharmaceutical corporation
that discover, develops,
manufactures and markets
branded health care products.
2012
Source:http://www.gsk.com/content/dam/gsk/globals/documents/pdf/GSK-Annual-Report-2012.pdf
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4. Key Facts
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5. GlaxoSmithKline - Mission
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6. GlaxoSmithKline - Where they are?
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7. GSK - Turnover
Source:http://www.gsk.com/content/dam/gsk/globals/documents/pdf/GSK-Annual-Report-2012.pdf
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8. Healthcare Portfolio
Pharmaceuticals
Infectious diseases
Cancer
Epilepsy
Heart Disease
Asthma and chronic
pulmonary disease
AIDS
Vaccines
Hepatitis A and B
Diphtheria, Tetanus,
Whooping cough
Polio
Measles, Mumps,
Rubella
Typhoid
Influenza
Bacterial meningitis
Consumer
Healthcare
Oral Care
Nutritional
Total wellness
Skin Health
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9. Healthcare Portfolio
Source:http://www.gsk.com/content/dam/gsk/globals/documents/pdf/GSK-Annual-Report-2012.pdf
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10. GlaxoSmithKline Vaccines – Market Share
Source: http://who.int/influenza_vaccines_plan/resources/session_10_kaddar.pdf
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11. Influenza
Influenza (the flu) contagious respiratory disease caused by
influenza viruses.
Affect the respiratory track (nose, throat and lungs).
Symptoms : fever, headache, malaise, cough, sore throat, nasal
congestion and body aches.
10% to 20% of the population is infected with influenza
virus each year
It can cause to severe illness and at times lead to death.
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12. Types of Influenza Virus
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Sr.
No
Basis Type A Type B Type C
1 Symptoms Moderate to Severe Mild Mild
2 Age Group All Primarily children All
3 Affect Humans and animal Affects human
only
Affects human
only
4 Divided Subdivided based on
antigenic differences
Not divided into
sub types
Not divided
into sub types
5 Epidemics Widespread Regional Don’t cause
6 Experienced Mostly Less Common
than type A
Rarely
Reported

13. Influenza A Virus
Is subdivide into two distinct large surface glycoprotein's antigens.
H- Haemagglutinin which initiates infection and attachment of
virus to the susceptible cell
N- Neuraminidase which is responsible for release of virus from the
infected cell
Mutations in the antigenic structure of the influenza virus have
resulted in a number of different influenza subtypes and strains
(antigenic drift)
H Type (1-15) and N Type (1-9)
Only H1, H2 and H3 and N1, N2 are found in humans.
Example: H1N1,H2N2,H3N2 etc.
Source: Karl G Nicholson, John M Wood, Maria Zambon, THE LANCET • Vol 362 • November 22, 2003 • www.thelancet.com
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14. Influenza Virus
Source: http://en.wikipedia.org/wiki/File:InfluenzaNomenclatureDiagram.svg
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15. Influenza Outbreak
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16. Types of Influenza Vaccines
Inactivated Vaccine (Killed)
• These type of vaccine are produced by killing the virus with
chemicals, heat or radiation.
• There are three types of inactivated vaccine whole virus, split
virus and subunit vaccine.
• They are generally injected (intramuscular).
Live Attenuated Vaccine
• The vaccine contain a version of weakened strain of virus.
• They are given intranasal.
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17. Fluarix
Suspension for injection supplied in 0.5-mL single-dose
prefilled syringes
Composition:
• A/Christchurch/16/2010 (H1N1)
• A/Texas/50/2012 (H3N2)
• B/Massachusetts/2/2012
Source: https://www.gsksource.com/gskprm/en/US/adirect/gskprm?cmd=ProductDetailPage&product_id=1244169218783&featureKey=600572
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18. Fluarix Quadrivalent
Suspension for injection supplied in 0.5-mL
single-dose prefilled syringes
Composition:
• A/Christchurch/16/2010 (H1N1)
• A/Texas/50/2012 (H3N2)
• B/Brisbane/3/2007
• B/Brisbane/60/2008
Source: https://www.gsksource.com/gskprm/en/US/adirect/gskprm?cmd=ProductDetailPage&product_id=1358783243411&featureKey=603902
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19. FluLaval
Supplied in a 5-mL multi-dose vial containing
10 doses (0.5-mL each)
Composition:
• A/California/7/2009 (H1N1)
• A/Texas/50/2012 (H3N2)
• B/Massachusetts/2/2012
Source: https://www.gsksource.com/gskprm/en/US/adirect/gskprm?cmd=ProductDetailPage&product_id=1244169337831&featureKey=600581
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20. FluLaval Quadrivalent
Supplied in a 5-mL multi-dose vial
containing 10 doses (0.5 mL each)
Composition:
• A/California/7/2009 (H1N1)
• A/Texas/50/2012 (H3N2)
• B/Massachusetts/2/2012
• B/Brisbane/60/2008
Source:https://www.gsksource.com/gskprm/en/US/adirect/gskprm?cmd=ProductDetailPage&product_id=1378227924542&featureKey=604242
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21. Pandemrix
For influenza pandemic (H1N1)
also know as swine flu
Supplied as suspension to be
mixed with emulsion adjuvant
(AS03) before injection
Composition:
• A/California/7/2009 (H1N1)
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22. GSK Flu Vaccine Development Process
Source: http://www.gsk.com/content/dam/gsk/globals/documents/pdf/GSK-Flu-Vaccine-Production-Process.pdf
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23. GSK Flu Vaccine Development Process
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24. GSK Flu Vaccine Development Process
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25. GSK Flu Vaccine Development Process
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26. 12/3/2014 GSK - Influenza Virus Vaccine 26

27. References
http://www.gsk.com/about-us/what-we-do.html
http://www.gsk.com/products/our-vaccines.html
https://www.gsksource.com/gskprm/en/US/adirect/gskprm?cmd=Produc
tsByName#F
http://www.gsk.com/content/dam/gsk/globals/documents/pdf/GSK-Annual-
Report-2012.pdf
http://www.gsk.com/content/dam/gsk/globals/documents/pdf/GSK-Flu-
Vaccine-Production-Process.pdf
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