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GENERAL PHYSIOLOGY Dr. Pavithran.P Assistant Professor in Physiology A J Institute of Medical Sciences, Mangalore
What is Physiology Physiology is the study of life, specifically, how cells, tissues, and organisms function.  Pronounced “fizzy-aw-low-jee” 2
Q: Why do we shiver, when we feel cold? To help us warm up, as shivering increases body temp  How does this happen – not answered What is the cause – not answered What will be its effect - answered 3
4 Temperature sensitive nerve cells  detects fall in temperature Impulses transmitted to brain  Hypothalamus Brain areas gets activated Involuntary, oscillating muscle contraction (Shivering) Increases body temperature
Internal environment&Homeostasis 5
External environment – surrounding environment. Amoeba- Unicellular Organism Takes nutrients and expels waste – external environment  6
Cells in human body – all does not have contact with external environment. How do they support their vital activities? Extra cellular fluid-the internal environment. 7
Majority inside the cells –intracellular fluid (ICF). 1/3rd – out side the cells- Extracellular fluid (ECF). ECF contains ions and nutrients ECF – internal environment for the cells – Milieu Intérieur 8
Milieu Interieur Milieu- Environment Interieur – Internal 19th French Physiologist. Concept of the internal environment of an organism. Blood- as the internal environment. (1813-1878) 9
10
Homeostasis:Homeo: same; stasis: stayThe word does not imply something set and immobile, a stagnation. It means a condition — a condition which may vary, but which is relatively constant 11 Walter Cannon (1871–1945) Homeostasis: maintenance of a constant internal environment.  An extension of Claude Bernard idea
12
Homeostatic mechanism Three part mechanism Receptor Control center Effector 13
14
The internal state of the body - dynamic equilibrium (balanced change). There is a certain set point or average value for a given variable (such as 37°C for body temperature).  Conditions fluctuate slightly around this point. 15
16
Regulatory Mechanism
Negative feedback mechanism Positive feedback mechanisms Feedforward mechanism 18
NEGATIVE FEEDBACK MECHANISM
Most of the control mechanisms in human body The body senses an internal change and activates mechanisms that reverse, or negate, that change. ,[object Object]
Increase in BP  is detected by various mechanism that lead to a decrease in BP20
21 ,[object Object],[object Object],[object Object]
A process in which the body senses a change and activates mechanisms that accelerate or increase that change. Child birth (Parturition reflex) Uterine contractions due to Oxytocin Baby’s head pushes against the cervix -stretch Sends impulse to the uterus Stimulates further contractions of the uterus Pushing the baby out. Milk ejection reflex 24
25
FEEDFORWARD MECHANISM
Body responds in anticipation of a change in regulated variable. In GIT- insulin secretion is increased Insulin increases cellular uptake and storage of ingested nutrients after they are absorbed. This limits the rise in blood sugar/nutrients after absorption 27
Disruption System malfunction Homeostasis not maintained Pathophysiology Severe - death 28
General physiology

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General physiology

  • 1. GENERAL PHYSIOLOGY Dr. Pavithran.P Assistant Professor in Physiology A J Institute of Medical Sciences, Mangalore
  • 2. What is Physiology Physiology is the study of life, specifically, how cells, tissues, and organisms function.  Pronounced “fizzy-aw-low-jee” 2
  • 3. Q: Why do we shiver, when we feel cold? To help us warm up, as shivering increases body temp How does this happen – not answered What is the cause – not answered What will be its effect - answered 3
  • 4. 4 Temperature sensitive nerve cells detects fall in temperature Impulses transmitted to brain Hypothalamus Brain areas gets activated Involuntary, oscillating muscle contraction (Shivering) Increases body temperature
  • 6. External environment – surrounding environment. Amoeba- Unicellular Organism Takes nutrients and expels waste – external environment 6
  • 7. Cells in human body – all does not have contact with external environment. How do they support their vital activities? Extra cellular fluid-the internal environment. 7
  • 8. Majority inside the cells –intracellular fluid (ICF). 1/3rd – out side the cells- Extracellular fluid (ECF). ECF contains ions and nutrients ECF – internal environment for the cells – Milieu Intérieur 8
  • 9. Milieu Interieur Milieu- Environment Interieur – Internal 19th French Physiologist. Concept of the internal environment of an organism. Blood- as the internal environment. (1813-1878) 9
  • 10. 10
  • 11. Homeostasis:Homeo: same; stasis: stayThe word does not imply something set and immobile, a stagnation. It means a condition — a condition which may vary, but which is relatively constant 11 Walter Cannon (1871–1945) Homeostasis: maintenance of a constant internal environment. An extension of Claude Bernard idea
  • 12. 12
  • 13. Homeostatic mechanism Three part mechanism Receptor Control center Effector 13
  • 14. 14
  • 15. The internal state of the body - dynamic equilibrium (balanced change). There is a certain set point or average value for a given variable (such as 37°C for body temperature). Conditions fluctuate slightly around this point. 15
  • 16. 16
  • 18. Negative feedback mechanism Positive feedback mechanisms Feedforward mechanism 18
  • 20.
  • 21. Increase in BP is detected by various mechanism that lead to a decrease in BP20
  • 22.
  • 23. A process in which the body senses a change and activates mechanisms that accelerate or increase that change. Child birth (Parturition reflex) Uterine contractions due to Oxytocin Baby’s head pushes against the cervix -stretch Sends impulse to the uterus Stimulates further contractions of the uterus Pushing the baby out. Milk ejection reflex 24
  • 24. 25
  • 26. Body responds in anticipation of a change in regulated variable. In GIT- insulin secretion is increased Insulin increases cellular uptake and storage of ingested nutrients after they are absorbed. This limits the rise in blood sugar/nutrients after absorption 27
  • 27. Disruption System malfunction Homeostasis not maintained Pathophysiology Severe - death 28

Editor's Notes

  1. Thermostat mechanism in an AC, fridge