3. Common precursor cell
For lactotropes and somatotropes
May give rise to a tumor secreting both
prolactin and growth hormone
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4. When does prolactin synthesis
begin?
Fetus
12 weeks gestation
4 weeks after GH
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13. Prolactin
Suppresses hypothalamic GnRH
Inhibit the release of LH and FSH
Impair gonadal steroidogenesis
Hypoestrogenism and anovulation
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14. Prolactin
Ensure that maternal lactation is sustained
Not interrupted by pregnancy
Decreases reproductive function
Suppress sexual drive
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15. Increase calcium absorption
Gastrointestinal calcium absorption is
increased
Bone calcium is mobilized
Hyperprolactinemia
Increases bone loss
May cause osteoporosis
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17. Which of the following is not a
prolactin action?
A. Induce and maintain lactation
B. Anovulation
C. Decreased spermatogenesis
D. Increase calcium absorption
E. Pubertal mammary development
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18. Answer
Pubertal mammary development
Prolactin is not essential
Requires GH
Action mediated by IGF-I
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19. What is the most common
pituitary hormone
hypersecretion syndrome in
males?
A. Acromegaly
B. Cushing’s disease
C. Hyperprolactinemia
D. Diabetes
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20. Answer
Hyperprolactinemia
Both males and females
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Endocrinology
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