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F E B R U A R Y  2 0 0 7 Commercializing Science: A Venture Capital Perspective R O B E R T  F.  H I G G I N S H A R V A R D  B U S I N E S S  S C H O O L S C I E N C E – B A S E D  B U S I N E S S  S E M I N A R
Overview ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Background
My Background ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Highland Capital Partners
Representative Highland Successes
Highland Healthcare / Life Sciences Team ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Highland Healthcare Focus Areas 42 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],LIFE SCIENCES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],CURRENT INVESTMENT THEMES MEDICAL DEVICES HEALTHCARE SERVICES ,[object Object],[object Object],[object Object],[object Object],HIGHLAND PHILOSOPHY
Representative Highland Healthcare Investments 42 HEALTHCARE SERVICES LIFE SCIENCES MEDICAL DEVICES
VC Investing Environment
Deal Flow & Equity into VC-Backed Companies Amount Invested ($B) Number of Deals Source: Dow Jones VentureOne/Ernst &Young $25.7 2454 2006
Where are the VC dollars going? Dollars Invested 2006 IT 54% Other 4% Business & Consumer 10% Healthcare 32% Biopharma 57% Healthcare IT/IS 5% Healthcare Services 6% Medical Devices 32% Source: Dow Jones VentureOne/Ernst &Young $25.7 Billion $8.2 Billion
Tech Transfer Environment
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],History
[object Object],[object Object],[object Object],[object Object],[object Object],How Universities Measure Success
0 0.5 1.0 10 5 0 1.5 15 US patents (in ‘000s) filed issued Net license income $B US University Patents & Licensing Trends 93 94 95 96 97 98 99 00 01 02 03 Source: The Economist & Association of University Technology Managers
Milken’s “Top Ten” Rankings Source: The Milken Institute Mind to Market: A Global Analysis of University Biotechnology Transfer and Commercialization, September 2006 By Number of Publications By Number of Patents Issued By Number of Start-ups UCLA 10 Univ of Wash 9 Wash U, St. Louis 8 Johns Hopkins 7 UCSD 6 UPenn 5 UCSF 4 University of London 3 University of Tokyo 2 Harvard University 1 University Rank Penn State University 10 Harvard University 9 Univ of Michigan 8 Univ of Chicago 7 UCSF 6 Univ of Wisconsin 5 Johns Hopkins 4 Stanford 3 MIT 2 CalTech 1 University Rank Univ of Minnesota 10 UPenn 9 USC 8 Univ of Illinois 7 Univ of Michigan 6 Stanford University 5 Georgia Tech 4 Caltech 3 Univ of CA System 2 MIT 1 University Rank
Overall “Top Ten” in Tech Transfer Source: The Milken Institute Mind to Market: A Global Analysis of University Biotechnology Transfer and Commercialization, September 2006 Milken’s “University Technology Transfer & Commercialization Index” 2000 – 2004 *** Harvard University New York University University of Michigan University of British Columbia Brigham Young University University of Minnesota University of Florida Stanford University Caltech University of CA System MIT University 10 18 9 8 7 6 5 4 3 2 1 Rank
Commercializing Scientific Research: The VC View
Evaluating Opportunities: VC Criteria ,[object Object],[object Object],[object Object],[object Object]
People (Founders) ,[object Object],[object Object],[object Object],[object Object]
Market ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Technology / Product ,[object Object],[object Object],[object Object],[object Object]
Deal ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Case Studies
[object Object],[object Object],[object Object],[object Object],[object Object],P E R V A S I S  T H E R A P E U T I C S $19.9 million A M O U N T  R A I S E D Highland Capital Partners Flagship Ventures Polaris Ventures V C  I N V E S T O R S Bob Langer, MIT Elazer Edelman, Harvard/MIT Jay Vacanti, Harvard/MGH F O U N D E R S
P E R V A S I S  T H E R A P E U T I C S
P E R V A S I S  T H E R A P E U T I C S
P E R V A S I S  T H E R A P E U T I C S Pig
[object Object],[object Object],[object Object],[object Object],[object Object],C O D O N  D E V I C E S $33 million A M O U N T  R A I S E D Highland Capital, Flagship Ventures, Khosla Ventures, Kleiner Perkins, Alloy Ventures V C  I N V E S T O R S George Church, HMS Joe Jacobson & Drew Endy, MIT Jay Keasling, UC Berkeley F O U N D E R S
C O D O N  D E V I C E S
[object Object],[object Object],[object Object],[object Object],[object Object],M A G E N  B I O S C I E N C E S $17.2 million A M O U N T  R A I S E D Highland Capital Partners Venrock Associates TVM Capital V C  I N V E S T O R S David Fisher, Harvard, DFCI Bob Langer, MIT Phil Sharp, MIT, Nobel Laureate F O U N D E R S
M A G E N  B I O S C I E N C E S
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],A V E O  P H A R M A C E U T I C A L S $58 million A M O U N T  R A I S E D Highland, MPM, Flagship, Oxford, Prospect, Venrock, and Greylock, and Merck V C  I N V E S T O R S Ron DiPinho, HMS, DFCI Lynda Chin, HMS, DFCI F O U N D E R S
A V E O  P H A R M A C E U T I C A L S ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],C O N O R  M E D S Y S T E M S $84 million (pre-IPO) A M O U N T  R A I S E D Highland Capital Partners Easton Hunt Capital, Maverick, Radius Ventures  V C  I N V E S T O R S Jeff Shanley, VP Engineering for Purus, Inc. F O U N D E R
Conor’s CoStar Stent C O N O R  M E D S Y S T E M S
P R E D I C T I V E  B I O S C I E N C E S ,[object Object],[object Object],[object Object],[object Object],$10 million A M O U N T  R A I S E D Highland Capital Partners IDG Ventures V C  I N V E S T O R S Marsha Moses and Bruce Zetter, Harvard Medical School & Children’s Hospital F O U N D E R S
Summary
Rules for Success ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
F E B R U A R Y  2 0 0 7 Commercializing Science: A Venture Capital Perspective R O B E R T  F.  H I G G I N S H A R V A R D  B U S I N E S S  S C H O O L S C I E N C E – B A S E D  B U S I N E S S  S E M I N A R

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HIGGINS COMMERCIALIZING SCIENCE - SOI.ppt

  • 1. F E B R U A R Y 2 0 0 7 Commercializing Science: A Venture Capital Perspective R O B E R T F. H I G G I N S H A R V A R D B U S I N E S S S C H O O L S C I E N C E – B A S E D B U S I N E S S S E M I N A R
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  • 9. Representative Highland Healthcare Investments 42 HEALTHCARE SERVICES LIFE SCIENCES MEDICAL DEVICES
  • 11. Deal Flow & Equity into VC-Backed Companies Amount Invested ($B) Number of Deals Source: Dow Jones VentureOne/Ernst &Young $25.7 2454 2006
  • 12. Where are the VC dollars going? Dollars Invested 2006 IT 54% Other 4% Business & Consumer 10% Healthcare 32% Biopharma 57% Healthcare IT/IS 5% Healthcare Services 6% Medical Devices 32% Source: Dow Jones VentureOne/Ernst &Young $25.7 Billion $8.2 Billion
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  • 16. 0 0.5 1.0 10 5 0 1.5 15 US patents (in ‘000s) filed issued Net license income $B US University Patents & Licensing Trends 93 94 95 96 97 98 99 00 01 02 03 Source: The Economist & Association of University Technology Managers
  • 17. Milken’s “Top Ten” Rankings Source: The Milken Institute Mind to Market: A Global Analysis of University Biotechnology Transfer and Commercialization, September 2006 By Number of Publications By Number of Patents Issued By Number of Start-ups UCLA 10 Univ of Wash 9 Wash U, St. Louis 8 Johns Hopkins 7 UCSD 6 UPenn 5 UCSF 4 University of London 3 University of Tokyo 2 Harvard University 1 University Rank Penn State University 10 Harvard University 9 Univ of Michigan 8 Univ of Chicago 7 UCSF 6 Univ of Wisconsin 5 Johns Hopkins 4 Stanford 3 MIT 2 CalTech 1 University Rank Univ of Minnesota 10 UPenn 9 USC 8 Univ of Illinois 7 Univ of Michigan 6 Stanford University 5 Georgia Tech 4 Caltech 3 Univ of CA System 2 MIT 1 University Rank
  • 18. Overall “Top Ten” in Tech Transfer Source: The Milken Institute Mind to Market: A Global Analysis of University Biotechnology Transfer and Commercialization, September 2006 Milken’s “University Technology Transfer & Commercialization Index” 2000 – 2004 *** Harvard University New York University University of Michigan University of British Columbia Brigham Young University University of Minnesota University of Florida Stanford University Caltech University of CA System MIT University 10 18 9 8 7 6 5 4 3 2 1 Rank
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  • 27. P E R V A S I S T H E R A P E U T I C S
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  • 29. P E R V A S I S T H E R A P E U T I C S Pig
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  • 31. C O D O N D E V I C E S
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  • 33. M A G E N B I O S C I E N C E S
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  • 37. Conor’s CoStar Stent C O N O R M E D S Y S T E M S
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  • 41. F E B R U A R Y 2 0 0 7 Commercializing Science: A Venture Capital Perspective R O B E R T F. H I G G I N S H A R V A R D B U S I N E S S S C H O O L S C I E N C E – B A S E D B U S I N E S S S E M I N A R

Notas del editor

  1. Mention what Kent asked you to speak about what VCs look for when commercializing science Greg Verdine, Eric Lander, etc. have already spoken at seminar