Human Variation Database

1. Variome Browser v0.1 Cheng-Yang (Louis) Tang BioIT at NGC 2008/11/28 http://vb.ngc.sinica.edu.tw

5. Data

6. Target Bases 3' Intron Exon 5' Promoter Gene Structure 5’ UTR 3’ UTR CDS

7. Target Bases 3' Intron Exon 5' Promoter Gene Structure 5’ UTR 3’ UTR CDS A

8. Target Variations 3' 5' A

9. Target Variations 3' 5' T G C A

10. Target Variations 3' 5' Transcript 001 Transcript 002 Transcript 003 T G C A A A A

11. Target Variations 3' 5' Transcript 001 Transcript 002 Transcript 003 Possible base-change ( 3 ) x transcript number ( 3 ) = variation number ( 9 ) T G C A A A A

12. Variation Impact Variation

13. Variation Impact Variation Disease db

14. Variation Impact Variation SNP Disease db

15. Variation Impact Variation SNP Risk evaluation Rescue-ESE FAS-ESS Disease db

17. Risk Evaluation Tabor HK, Risch NJ, Myers RM: Candidate-gene approaches for studying complex genetic traits: practical considerations. Nature Reviews Genetics 2002, 3(5):391-397 .

26. Risk Evaluation Workflow

28. User Interface

29. User Interface

30. User Interface

31. User Interface 1. Search

32. User Interface 1. Search 2. Image

33. User Interface 1. Search 2. Image 3. Table

34. User Interface 1. Search 4. History 2. Image 3. Table

35. User Interface 1. Search 4. History 2. Image 3. Table 5. Filter

36. Search

38. Search

39. Advanced Search

40. Advanced Search

41. Advanced Search

42. Advanced Search

43. Advanced Search

44. Advanced Search

45. Image

46. Image

47. Image

48. Image 1. Genome View

49. Image 1. Genome View 2. Chromosome View

50. Image 1. Genome View 2. Chromosome View 3. Transcript View

51. Image

52. Image

53. Image

54. Image

55. Table

60. Details

61. Variant Details

62. Impact

63. Risk Evaluation

64. SNP

65. Disease

66. Risk Evaluation Flow

67. History

68. History

69. Filter

70. Filter

71. Filter

72. Live Demo http://vb.ngc.sinica.edu.tw/

73. Future

81. Acknowledgement 緣起：陳志成老師、所長實驗室 指導：姚文萱老師 支援： NGC, Biomedical IT 經費： NRPGM

82. Thanks for your attention! http://vb.ngc.sinica.edu.tw