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ABOUT KLIPPEL-
TRENAUNAY
SYNDROME
By Mitar Vranic
Introduction
 Since 2005, Dr. Mitar Vranic has cared for patients at
Arizona's Western Vascular Institute. There, Dr. Mitar Vranic
treats vascular conditions ranging from venous insufficiency
to Klippel-Trenaunay Syndrome.
A congenital malformation of the blood vessels, skin, and soft
tissue, Klippel-Trenaunay Syndrome typically makes itself
known through the appearance of abnormal venous growths.
The majority of patients with the syndrome are born with a
port-wine birthmark, pink to red in color and created by the
swelling of blood vessels near the skin. In most patients, it
extends over the majority of one limb.
Similarly, Klippel-Trenaunay Syndrome causes malformation
of both surface and deep veins. Surface vein malformations
often present as varicose veins, which have a twisted and
enlarged appearance.
Klippel-Trenaunay Syndrome
 Malformations in deeper veins may be less
aesthetically obvious but can be more dangerous, as
they increase a patient's risk of a blood clot known as
deep vein thrombosis (DVT). This condition is
potentially fatal, as material from the clot may break
off and travel to the lungs, where it can cause a
pulmonary embolism (PE).
Patients with Klippel-Trenaunay Syndrome also
experience abnormal growth in a limb or limbs, though
the rare patient experiences these symptoms in the
trunk. Patients typically report feelings of heaviness
and trouble with movement, as well as pain. In some
cases, excessive growth of one leg causes difficulty
walking. Less common signs include the fusion of
digits or growth of extra fingers or toes.

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About Klippel-Trenaunay Syndrome

  • 2. Introduction  Since 2005, Dr. Mitar Vranic has cared for patients at Arizona's Western Vascular Institute. There, Dr. Mitar Vranic treats vascular conditions ranging from venous insufficiency to Klippel-Trenaunay Syndrome. A congenital malformation of the blood vessels, skin, and soft tissue, Klippel-Trenaunay Syndrome typically makes itself known through the appearance of abnormal venous growths. The majority of patients with the syndrome are born with a port-wine birthmark, pink to red in color and created by the swelling of blood vessels near the skin. In most patients, it extends over the majority of one limb. Similarly, Klippel-Trenaunay Syndrome causes malformation of both surface and deep veins. Surface vein malformations often present as varicose veins, which have a twisted and enlarged appearance.
  • 3. Klippel-Trenaunay Syndrome  Malformations in deeper veins may be less aesthetically obvious but can be more dangerous, as they increase a patient's risk of a blood clot known as deep vein thrombosis (DVT). This condition is potentially fatal, as material from the clot may break off and travel to the lungs, where it can cause a pulmonary embolism (PE). Patients with Klippel-Trenaunay Syndrome also experience abnormal growth in a limb or limbs, though the rare patient experiences these symptoms in the trunk. Patients typically report feelings of heaviness and trouble with movement, as well as pain. In some cases, excessive growth of one leg causes difficulty walking. Less common signs include the fusion of digits or growth of extra fingers or toes.