1. Mohit kadyan
Roll no:26

2. 
Papillary carcinoma (>85% os cases)

Follicular carcinoma (5 to 15% of cases)

Medullary carcinomas (5% of cases)

Anaplastic carcinomas(<5%) of cases)

3. 
Most thyroid carcinomas (except medullary
carcinomas) are derived from the thyroid
follicular epithelium and are well
differentiated lesions.

Medullary carcinomas are derived from
parafollicular cells or “ C” cells.

4. 
Commonest form of thyroid carcinoma

Can occur at any age but more often seen in 25
to 50 yrs of age

Commonest form associated with radiation
exposure

Metastasis via lymphatics

Excellent prognosis with 10yr survival rate in
95% patients

5. Solitary or multifocal
lesions
 It can be soft, cystic,
hard, firm.
 Well circumscribed &
encapsulated.
 Cut surface reveals
papillae


6. The nuclei appear optically
clear, giving rise to “ ground
glass appearance”
It shows cystic spaces ,
papillary projections with
psammoma bodies
Malignant cells shows
invaginations of cytoplasm in
nuclei “ Orphan annie eye”
(pseudo-inclusions)

8. 
Common in women (3:1) & present at older
age than papillary carcinoma.

Peak incidence in 40 t0 60 yrs of age.

More incidence in areas with dietary iodine
deficiency

Metastasise through blood to lungs , bone
&liver. Prognosis is poorer than papillary Ca.

9. Single nodules, may be
well circumscribed or
infiltrative
 Gray to tan on cut
section and translucent
due to colloid filled
follicles

Uniform cells form
small follicles
containing colloid.
 Sometimes
differentiation is less.
Nests and sheets of
cells & no colloid.


10. 
Is a varient of follicular carcinoma of thyroid
which contains abundant oxyphill cells

11. 
Neuroendocrine neoplasm derived from
parafollicular cells ,”C” cells.

Secrete calcitonin –helpful in diagnosis &
follow-up.

They are aggressive and metastasise more
frequently.

12. Solitary nodules
Large lesions contain
areas of hemorrhage and
necrosis
 Tumor tissue is firm, pale,
gray to tan and infiltrative.


Composed of polygonal
to spindle shaped cells,
which form nests ,
trabaculae and even
follicles.
 Acellular amyloid
deposits are present.


13. 
One of the most aggressive malignancies

Found in elderly , rare , less than <5%

Metastasis is common, through lymphatics
&blood

Death is usually from rapid from aggressive local
growth

Mortality is 100%

14. 
Large solid tumour
with necrosis &
hemorrhage that
invades surrounding
structures

15. 



Composed of highly anaplastic cells , includes
Pleomorphic giant cells
Spindle cells
Mixed spindle and giant cells

16. 
Solitary nodules are more likely to be
neoplastic than multiple nodules.

Nodules in younger patients are more likely
to be neoplastic than those in elder.

Nodules in males are more likely to be
neoplastic than are those in females.

17. 
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