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Bioavailability Of Disperse Dosage Form

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Mohammad Sohail
Mohammad Sohail

Pharmaceutics

EducaciónTecnologíaEmpresariales
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Bioavailability Of Disperse Dosage Forms By Mohammad Sohail Mphil pharmaceutics Islamia university Bahawalpur [email_address]
Bioavailability Of Disperse Dosage Forms ,[object Object],[object Object],[object Object],[object Object],[object Object]
Relative Bioavailability ,[object Object],[object Object]
RBA ,[object Object],[object Object],[object Object],[object Object],[object Object]
Absolute Bioabavailability ,[object Object],[object Object],[object Object]
Absolute Bioavailability ,[object Object],[object Object],[object Object],[object Object]
Difference between Absolute and Relative Bioavailability ,[object Object],[object Object],[object Object],[object Object],[object Object]
AB vs RBA Drug Product AUC ( mcg/ml . hr ) A IV Injection 100 B Oral dosage form (Refer) 50 C Oral dosage form (generic) 40
Bioequivalent Drug Products ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Disperse Systems ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Routes Of Drug Administration ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Properties Of Disperse Dosage Form ,[object Object],[object Object],[object Object],[object Object]
Properties Of Disperse Dosage Form ,[object Object],[object Object],[object Object],[object Object]
Advantages Of Disperse Dosage Form ,[object Object],[object Object],[object Object],[object Object]
Formulation Factors Affecting Drug Release From Disperse Systems : ,[object Object],[object Object],[object Object],[object Object],[object Object]
Wetting ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Particle Size ,[object Object],[object Object],[object Object],[object Object]
Particle Size ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Viscosity ,[object Object],[object Object],[object Object],[object Object]
Viscosity ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Drug release from disperse systems ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Absorption Barriers ,[object Object],[object Object]
Barriers for Skin
Barriers For Skin ,[object Object],[object Object],[object Object],[object Object]
pathways for percutaneous absorption: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Barriers For Eye
Barriers For Eye ,[object Object],[object Object],[object Object]
Barriers For Eye ,[object Object],[object Object],[object Object]
Barriers For GIT
Barriers For GIT ,[object Object],[object Object],[object Object],[object Object]
Barriers for GIT ,[object Object],[object Object]
Barrier for Pulmonary Drug Delivery ,[object Object],[object Object],[object Object],[object Object]
Barriers for Pulmonary Drug Delivery ,[object Object],[object Object],[object Object]
Absorption Factors SKIN EYE GIT Barrier Stratum corneum Superficial layer of epithelium Epithelium Thickness 8-26 layers 5-6 layers 1 layer hydration 10-25% 78% High area 2-25cm 2 1.3cm 2 2,000,000
Physiological Factors Affecting Absorption ,[object Object],[object Object],[object Object],[object Object],[object Object]
Factors affecting Percutaneous Absorption ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Factors affecting Percutaneous Absorption ,[object Object],[object Object],[object Object],[object Object]
Factors affecting Percutaneous Absorption ,[object Object],[object Object],[object Object],[object Object]
Percutaneous Absorption ,[object Object],[object Object],[object Object],[object Object],[object Object]
Percutaneous Absorption ,[object Object],[object Object],[object Object]
Factors affecting Ophthalmic Absorption ,[object Object],[object Object],[object Object],[object Object],[object Object]
Factors affecting Ophthalmic Absorption ,[object Object],[object Object],[object Object]
Factors affecting G.I.T Absorption ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Factors affecting G.I.T Absorption ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
pH Location pH Stomach Duodenum Jejunum Ileum Colon Rectum 1.5-3.5 5-7 6-7 6.0-7.5 5.5-7.0 7
pH ,[object Object],[object Object]
Metabolism ,[object Object],[object Object],[object Object],[object Object],[object Object]
Metabolism ,[object Object],[object Object],[object Object],[object Object]
Metabolism ,[object Object],[object Object]
Presence Of Food ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Presence Of Food ,[object Object],[object Object]
Individual variation ,[object Object],[object Object],[object Object],[object Object]
Gender ,[object Object],[object Object]
Race ,[object Object],[object Object],[object Object]
Example ,[object Object],[object Object],[object Object],[object Object]
Age ,[object Object],[object Object],[object Object]
Methods Of Assessing Bioavailability Of Drugs ,[object Object],[object Object]
Methods Of Assessing Bioavailability Of Drugs ,[object Object],[object Object],[object Object],[object Object],[object Object]
Plasma Drug Concentration ,[object Object],[object Object],[object Object]
Plasma concentration vs. time profile of a single dose of a drug ingested orally Plasma Concentration
Key Parameters: ,[object Object],[object Object],[object Object],[object Object],[object Object]
AUC
Peak height or C max ,[object Object],[object Object],[object Object]
Time of occurrence or t max ,[object Object],[object Object],[object Object]
(2) Urinary Drug excretion Data ,[object Object],[object Object],[object Object]
Urinary Drug excretion
(3) Acute pharmacodynamic or pharmacologic effect ,[object Object],[object Object],[object Object]
Acute pharmacodynamic or pharmacologic effect ,[object Object],[object Object],[object Object]
Acute pharmacodynamic or pharmacologic effect
(4) Clinical Observations ,[object Object],[object Object],[object Object]
(5) In vitro Bioavailability studies ,[object Object],[object Object],[object Object],[object Object]
Gastrointestinal Bioavailability ,[object Object],[object Object],[object Object]
Gastrointestinal Bioavailability Oral suspension ,[object Object],[object Object],[object Object]
Oral suspension ,[object Object],[object Object]
Oral suspension ,[object Object],[object Object],[object Object],[object Object]
Oral suspension ,[object Object],[object Object],[object Object]
Oral suspension ,[object Object],[object Object]
Oral emulsion ,[object Object],[object Object],[object Object],[object Object],[object Object]
Dermatological Bioavailability ,[object Object],[object Object],[object Object],[object Object],[object Object]
Dermatological Bioavailability ,[object Object],[object Object],[object Object]
Dermatological Bioavailability ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Dermatological Bioavailability ,[object Object],[object Object],[object Object],[object Object],[object Object]
Measurement of Dermatological bioavailability ,[object Object],[object Object],[object Object],[object Object]
Procedure: ,[object Object],[object Object],[object Object]
Ophthalmic Bioavailability ,[object Object],[object Object],[object Object]
Ophthalmic suspensions : ,[object Object],[object Object],[object Object]
Ophthalmic suspensions : ,[object Object],[object Object]
Ophthalmic suspensions : ,[object Object],[object Object],[object Object]
Ophthalmic ointments : ,[object Object],[object Object]
Ophthalmic ointments : ,[object Object],[object Object],[object Object]
Ophthalmic ointments : ,[object Object]
Rectal bioavailability : ,[object Object],[object Object],[object Object]
Rectal suppositories : ,[object Object],[object Object],[object Object],[object Object]
Rectal suppositories : ,[object Object],[object Object]

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Bioavailability Of Disperse Dosage Form

  • 1. Bioavailability Of Disperse Dosage Forms By Mohammad Sohail Mphil pharmaceutics Islamia university Bahawalpur [email_address]
  • 2.
  • 3.
  • 4.
  • 5.
  • 6.
  • 7.
  • 8. AB vs RBA Drug Product AUC ( mcg/ml . hr ) A IV Injection 100 B Oral dosage form (Refer) 50 C Oral dosage form (generic) 40
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  • 31.
  • 32.
  • 33.
  • 34. Absorption Factors SKIN EYE GIT Barrier Stratum corneum Superficial layer of epithelium Epithelium Thickness 8-26 layers 5-6 layers 1 layer hydration 10-25% 78% High area 2-25cm 2 1.3cm 2 2,000,000
  • 35.
  • 36.
  • 37.
  • 38.
  • 39.
  • 40.
  • 41.
  • 42.
  • 43.
  • 44.
  • 45. pH Location pH Stomach Duodenum Jejunum Ileum Colon Rectum 1.5-3.5 5-7 6-7 6.0-7.5 5.5-7.0 7
  • 46.
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  • 59.
  • 60. Plasma concentration vs. time profile of a single dose of a drug ingested orally Plasma Concentration
  • 61.
  • 62. AUC
  • 63.
  • 64.
  • 65.
  • 67.
  • 68.
  • 69. Acute pharmacodynamic or pharmacologic effect
  • 70.
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  • 82.
  • 83.
  • 84.
  • 85.
  • 86.
  • 87.
  • 88.
  • 89.
  • 90.
  • 91.
  • 92.
  • 93.
  • 94.