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Principals of thermopuncture diagnosis
working system, monitoring and treatment of
           patients with diabetes.
       Valery Muzhikov, Phd, CEO of “Med Byte” Ltd.
                   Mail: mujikov_v@mail.ru




    “Home Doctor on a mobile phone




                    Gold medal - USA 2009
                    Silver medal RAVI - Moscow 2009
Our history.
We work on creation of devices for thermopunctur diagnostics and treatments
with 1990г. For this time it is issued more than 10 versions of devices. We have
received 14 patents in Russia and abroad, 3 monographies and more than 40
publications are issued. Now under license contracts devices are certificated,
made and sold in Europe, Asia, Australia and Russia.




                                          1990        1993      1995       1996




                                           1998      2000

                                                                    2004
                               German Patent DE 199 83 992 from
                               20.01.2009
                               РСТ PCT/RU2006/00567, WO 2008/054235
                   2007        A1 from 28.05.2008
MedByte
           Description of the technology
Over 15 years of work, we have created a new technology
for diagnosis and treatment on the basis of the influence
on certain information points on fingers modulated with
IR-radiation.
On the basis of this technology, we have created system
estimations of the level of biochemical and physiological
parameters of an organism calculated on the basis of
individual mathematical models on the training gauging.
The treatment is bloodless and painless and gives a
predicted result after just 15-20 minutes.
Simultaneously, with the help of an estimation of the
individual biorhythms of separate organs it is possible to
predict the condition of various parameters of an
organism for the next few days.
•   Our advantages:
•   Devices demand no special knowledge;
•   Gives a reliable result explained from the point
    of view of modern physiology;
•   Easy to mass produce;
•   Opportunity to forecast a condition for the next
    few days in order to address preventive
    treatment.
Basic principles of diagnosis
             1. Evaluation of pathology according to the channel map profile
•




                       Norm                                                     Ischemia of a
                                                                                myocardium




    The diagnosis of diseases and the control of
    the general condition are carried out on an
    estimation of structures of parameters on 12
    basic physiological systems of an organism.
                                                                               Pancreatitis
    Thus even simple visual estimation allows
    the features of each organism to be revealed.
Basic principles of diagnosis
    2. High correlation rate with blood sugar

•     Type 2 diabetes, men – channel rates’
•     Correlation with blood sugar                             Correlation with cholesterol
•         n observation    p                 p- criteria
•     1 143 .079 .940 .174 -.054 -.645 .260
•     2 143 -.209 -2.538 .006* -.220 -2.681 .004*
•     3 143 -.126 -1.512 .066 -.130 -1.561 .060
•     4 143 -.129 -1.549 .062 -.158 -1.896 .030
•     5 143 -.216 -2.630 .005* -.227 -2.774 .003*
•     6 143 -.262 -3.230 .001* -.250 -3.066 .001*
•     7 143 -.238 -2.905 .002* -.227 -2.770 .003*
•     8 143 -.265 -3.259 .001* -.272 -3.359 .001*
•     9 143 -.273 -3.374 .000* -.266 -3.273 .001*
•     10 143 -.113 -1.354 .089 -.234 -2.853 .002*
•     11 143 .071 .847 .199 -.076 -.910 .182
•     12 143 -.297 -3.687 .000* -.323 -4.051 .000*
•     13 143 -.079 -.939 .175 -.037 -.435 .332
•     14 143 .046 .547 .293 -.049 -.579 .282
•     15 143 -.024 -.290 .386 -.038 -.448 .327
•     16 143 -.057 -.679 .249 -.160 -1.924 .028
•     17 143 .128 1.532 .064 -.001 -.014 .494
•     18 143 .193 2.335 .010* .023 .271 .393
•     19 143 .045 .531 .298 -.006 -.069 .472
•     20 143 .021 .252 .401 .060 .712 .239
•     21 143 -.068 -.804 .211 -.104 -1.245 .108
•     22 143 .208 2.524 .006* .070 .835 .203
•     23 143 -.111 -1.330 .093 -.185 -2.238 .013*
•     24 143 .128 1.527 .065 .032 .381 .352
Basic principles of diagnosis
•    3. Making individual and group models to control basic the parameters of the
     organism

•   Group model of correlation between blood sugar in patients with type 1 diabetes
•   ---------------------------------------------------------------------------------------------------------------
•   Channels coefficients mean error t-critic. significance level
•   ---------------------------------------------------------------------------------------------------------------
•   constant                         23.881392 5.918608 4.0350                                    0.0005
•              RPs                     -6.106297 2.759818 -2.2126                                 0.0371
•               Fd                      6.432937 1.32788 4.8445                                   0.0001
•               Ed                    -13.91464 4.019018 -3.4622                                  0.0021
•               Rd                     -4.004711 1.893141 -2.1154                                 0.0454
•              RPd                      5.202921 1.436439 3.6221                                  0.0014
•   ---------------------------------------------------------------------------------------------------------------
•   R-SQ. (ADJ.) = 0.7522 SE=              8.393783 MAE=              5.667226 DurbWat= 1.814
•   Previously: 0.4522                 12.480549              7.979804             1.556
•   54 observations fitted, forecast(s) computed for 0 missing val. of dep. var.

• +Data Mining (Accuracy 0,8-0,9)
• + NGO (Accuracy 0,7-0,85)
Basic principles of diagnosis
               4. Estimation of specific features of an organism and mechanism indemnification in type 1 diabetes

           Ñðåäí è å ñ î ø è á êàì è è ñõî äí û õ ï î ðî ãî â ÷óâñòâè òåëüí î ñòè
           (í å í î ðì è ðî âàí í û õ í à ñóì ì àðí û å äàí í û å)                      Structures of activity of channels
     Amosov. Norma
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     Anna. Diabetes I
16                                    Type 1 diabetes with don't preserved-function B-cells
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       Borgest. Diabetes I
                                                                                    cells. These patients were selected on the
16

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                                                                                    basis of the test and may be included in
 8

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                                                                                    the basic research. They are most likely to
 4                                                                                  respond to Leptin treatment and most
                                                                                    effectively carry out the forecast state
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                                                                                    biorhythms.
Simple way of testing the organism at the level of its separate physiological systems based on an assessment of loss of
symmetry. The example of the pancreas (RP) has proved that the temperature pain barrier of the right channel's branch reflects
                                   the total activity of B-cells and the left one – for A-cells

                          This principle works at the level of all channels, due to its universal nature.




                 А-cells
Method of achieving quantitative assessment of the features of the principal organism.
        Blood sugar level assessment according to the degree of the channels’ misalignment.

Test of pancreas (RP)                                       6



       d       s
       Right   Left

                        Norm
       11 9

       48 6
                             Typical type 1 diabetes with partial preservation of
                             function B-cells.
                                    The presence of this atypical test asymmetry
       10 24                        along with high levels of blood sugar points to
                                    insulin resistance. In these patients, an
                                    increase in the level of sugar is due to the high
                                    activity of A-cells that produce the contra
                                    insulin hormone (Glyukogon). These patients
                                    will display the best responses to treatment
                                    with Leptin.
Assessing the biorhythmic activity of organs and the physiological system

                          Ä è í à ì è ê à î ò í î ø å í è é F ir e /W a te r _ d &                                                                   F ir e /W        a te r_ s
                          â çà â è ñè ì î ñò è î ò í î ì åð à è çì åð åí è ÿ
                                                                                                                                                                                               F ir e /W a te r _ d
                                              1                                                                                                                                                F ir e /W a te r _ s
             2 .0



             1 .5
Y Data




             1 .0



             0 .5



             0 .0                                                                                                                                                                                                                          The biorhythmic activity of the
                                                                                                                                                                                                                                           pancreas, liver and kidneys over 38
                      0           2               4       6           8       1 0         1 2         1 4         1 6       1 8        2 0      2 2      2 4         2 6         2 8    3 0   3 2      3 4             3 6         3 8

                                                                                                                           X        D a ta
                                                      2
               3 .0                                                                                                                                                                                                                        days based on the results of our
               2 .5                                                                                                                                                                                                                        tests.
    Y Data




               2 .0

               1 .5

               1 .0

               0 .5

               0 .0
                          0           2               4           6       8         1 0         1 2          1 4          1 6         1 8      2 0      2 2          2 4         2 6    2 8    3 0         3 2          3 4          3 6

                                                                                                                                X     D a ta
                                                      3
               3 .0

               2 .5
    Y Data




               2 .0

               1 .5

               1 .0

               0 .5

               0 .0
                              0           2           4       6       8       1 0    1 2        1 4         1 6     1 8         2 0    2 2     2 4     2 6     2 8         3 0    3 2   3 4   3 6    3 8         4 0         4 2     4 4

                                                                                                                                X     D a ta
The principal of generating biorhythms in the organ and its
                          channel

       ∆t>0            Norm




                         The organ does not work

                           ∆t=0
Basic principals of working system - prognosis of condition organ
                               Real gauging




                                                           Biorhythm




                                                       Prognosis




                                        real time at this moment
Basic principal of working system - prognosis of the condition of organs


                        MODEL: glucose = 8,6xRpd – 2,3xVBs


At different times
of the day, due to
the varied activity
of organs under
the action of
biorhythms, the
blood sugar level
also changes.
When estimating
a biorhythm, it is
possible to
predict the
change in sugar
for the next 1-2
days.

                                   T1                          T2
                                   Rp=5                        Rp=8
                                   Vbs=16                      Vbs=20
                                   Sugar=6мМoll/l              Sugar=23 мМоll/l
The device functions over a GPRS-connection


- The device works as an organiser with the creation of an optimum
lifecycle for patients with, for example, diabetes.
- The device indicates and forecasts blood sugar levels for the current            IR- sensor for
day by means of a real time diagram. The sugar level is shown not in               control and
digits but by the thickness of colour on the coloured scale, which
makes it easier for a patient to use and understand the information                treatment
- The system indicates an optimum dose of insulin and the time of
injection.
- The optimum time for a meal is defined with the help of an
estimation of the biorhythms of certain organs and is shown on a
screen.
- Measurements are made by touching certain acupoints on the fingers
                                                                          sugar- level
and toes using the special gauge with IR sensor
The concept of displaying the information to the user

The screen does not                               Diabetes 1 type
show absolute                                        Sugar
numerical values of
glucose. The level of                                Norma
glucose is shown on a
colour scale of varying
intensity, as on the
diagram. Thus, the
                              -                                             +
device is not a means                                                           high level
of metrology, and only     low level
shows the tendency in
sugar change (much,
very much or a little).
                                       SP                            SP
As required, the user is
able to place individual             Left                           Right
marks on the screen.
Furthermore, as soon
as a set of sufficient
                                               Sugar prediction
statistics is available,
the device can be            +
positioned individually
as a glucometer.              Norma

                             -         12:30                                    Time         15
The concept of displaying the information to the user

                                               Type 2 diabetes
                                                  Sugar

                                                  Norma



                          -                                           +
                            LI
                            LIV
                            GB        Left
                                                                    ST
                                                                    SI
The activity of each organ in an                                    LIV
                                                                    GB
individual model contributes to the                                 DI
formation of blood sugar levels.                            Right
                                             Sugar prediction

                          +
                          Norma

                          -       12:30                                   Time   16
The concept of displaying the information to the user
                                         Type 1 diabetes
First type diabetes. Influence of insulin doze.
              Sugar prediction

  +
  Norma
                                                      The device can be equipped with
  -                                                   a system for calculating an
                                                      optimum dose of insulin and the
                                             Time
                                                      time of optimum introduction.
   5 units                  5 units
                                                      Diagrams of influence of different
                                                      doses can be submitted to the
                                                      user and to his/her doctor for
                                                      download from the internet. This
                                                      allows one doctor to supervise
                                            Time
                                                      the condition of 30-40 patients
                                                      through the special PC
   10 units                 10 units                  programme on a daily basis.




  8:00        12:30       14:00              Time
System pulse - diagnosis on the basis of three-dimensional
                       analysis of the heart rhythm
Further development of the system
In the past, Chinese doctors defined the conditions of various organs on the basis of pulse diagnosis. We can also
do this by means of pulse diagnosis using a measurement of temperature sensitivity. We developed this system 12
years ago, but its realisation at the time was dependent on a powerful computer and specialised knowledge. Now,
the modern mobile phone allows basic calculations to be performed, with periodic transmission of data to a server.
Thus, if this principle is realised, the information concerning the activity of different organs will be transmitted to the
phone via sensors measuring heart contractions (for example from a special watch (“POLAR”) for controlling the
heart rhythm). These data will be processed on individual models on the basis of periodic calibration of the system.
In this case, the activity of the channels will be continuously estimated in real time, without the need for frequent
gauging.




                                                                                    Rhythm of heart contractions




                                                                              The special 3D spectral analysis
                                                                              of heart rhythm.
Heart rhythm spectral component estimation system

Diagram of organ activity over time




                   Numerical value of organ activity at the present time
Patents

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System for monitoring diabetes

  • 1. Principals of thermopuncture diagnosis working system, monitoring and treatment of patients with diabetes. Valery Muzhikov, Phd, CEO of “Med Byte” Ltd. Mail: mujikov_v@mail.ru “Home Doctor on a mobile phone Gold medal - USA 2009 Silver medal RAVI - Moscow 2009
  • 2. Our history. We work on creation of devices for thermopunctur diagnostics and treatments with 1990г. For this time it is issued more than 10 versions of devices. We have received 14 patents in Russia and abroad, 3 monographies and more than 40 publications are issued. Now under license contracts devices are certificated, made and sold in Europe, Asia, Australia and Russia. 1990 1993 1995 1996 1998 2000 2004 German Patent DE 199 83 992 from 20.01.2009 РСТ PCT/RU2006/00567, WO 2008/054235 2007 A1 from 28.05.2008
  • 3. MedByte Description of the technology Over 15 years of work, we have created a new technology for diagnosis and treatment on the basis of the influence on certain information points on fingers modulated with IR-radiation. On the basis of this technology, we have created system estimations of the level of biochemical and physiological parameters of an organism calculated on the basis of individual mathematical models on the training gauging. The treatment is bloodless and painless and gives a predicted result after just 15-20 minutes. Simultaneously, with the help of an estimation of the individual biorhythms of separate organs it is possible to predict the condition of various parameters of an organism for the next few days. • Our advantages: • Devices demand no special knowledge; • Gives a reliable result explained from the point of view of modern physiology; • Easy to mass produce; • Opportunity to forecast a condition for the next few days in order to address preventive treatment.
  • 4. Basic principles of diagnosis 1. Evaluation of pathology according to the channel map profile • Norm Ischemia of a myocardium The diagnosis of diseases and the control of the general condition are carried out on an estimation of structures of parameters on 12 basic physiological systems of an organism. Pancreatitis Thus even simple visual estimation allows the features of each organism to be revealed.
  • 5. Basic principles of diagnosis 2. High correlation rate with blood sugar • Type 2 diabetes, men – channel rates’ • Correlation with blood sugar Correlation with cholesterol • n observation p p- criteria • 1 143 .079 .940 .174 -.054 -.645 .260 • 2 143 -.209 -2.538 .006* -.220 -2.681 .004* • 3 143 -.126 -1.512 .066 -.130 -1.561 .060 • 4 143 -.129 -1.549 .062 -.158 -1.896 .030 • 5 143 -.216 -2.630 .005* -.227 -2.774 .003* • 6 143 -.262 -3.230 .001* -.250 -3.066 .001* • 7 143 -.238 -2.905 .002* -.227 -2.770 .003* • 8 143 -.265 -3.259 .001* -.272 -3.359 .001* • 9 143 -.273 -3.374 .000* -.266 -3.273 .001* • 10 143 -.113 -1.354 .089 -.234 -2.853 .002* • 11 143 .071 .847 .199 -.076 -.910 .182 • 12 143 -.297 -3.687 .000* -.323 -4.051 .000* • 13 143 -.079 -.939 .175 -.037 -.435 .332 • 14 143 .046 .547 .293 -.049 -.579 .282 • 15 143 -.024 -.290 .386 -.038 -.448 .327 • 16 143 -.057 -.679 .249 -.160 -1.924 .028 • 17 143 .128 1.532 .064 -.001 -.014 .494 • 18 143 .193 2.335 .010* .023 .271 .393 • 19 143 .045 .531 .298 -.006 -.069 .472 • 20 143 .021 .252 .401 .060 .712 .239 • 21 143 -.068 -.804 .211 -.104 -1.245 .108 • 22 143 .208 2.524 .006* .070 .835 .203 • 23 143 -.111 -1.330 .093 -.185 -2.238 .013* • 24 143 .128 1.527 .065 .032 .381 .352
  • 6. Basic principles of diagnosis • 3. Making individual and group models to control basic the parameters of the organism • Group model of correlation between blood sugar in patients with type 1 diabetes • --------------------------------------------------------------------------------------------------------------- • Channels coefficients mean error t-critic. significance level • --------------------------------------------------------------------------------------------------------------- • constant 23.881392 5.918608 4.0350 0.0005 • RPs -6.106297 2.759818 -2.2126 0.0371 • Fd 6.432937 1.32788 4.8445 0.0001 • Ed -13.91464 4.019018 -3.4622 0.0021 • Rd -4.004711 1.893141 -2.1154 0.0454 • RPd 5.202921 1.436439 3.6221 0.0014 • --------------------------------------------------------------------------------------------------------------- • R-SQ. (ADJ.) = 0.7522 SE= 8.393783 MAE= 5.667226 DurbWat= 1.814 • Previously: 0.4522 12.480549 7.979804 1.556 • 54 observations fitted, forecast(s) computed for 0 missing val. of dep. var. • +Data Mining (Accuracy 0,8-0,9) • + NGO (Accuracy 0,7-0,85)
  • 7. Basic principles of diagnosis 4. Estimation of specific features of an organism and mechanism indemnification in type 1 diabetes Ñðåäí è å ñ î ø è á êàì è è ñõî äí û õ ï î ðî ãî â ÷óâñòâè òåëüí î ñòè (í å í î ðì è ðî âàí í û õ í à ñóì ì àðí û å äàí í û å) Structures of activity of channels Amosov. Norma 16 14 12 10 8 • Normn Norm Norm 6 4 2 0 cd cs bd d bs s ld rd ls rs d s d d d s d d s s s d s s p Ig p V R C Ig E P F V R C E P F G M G T V M R T V R Anna. Diabetes I 16 Type 1 diabetes with don't preserved-function B-cells 14 12 10 8 6 4 2 0 cd cs bd d bs s ld rd ls rs d s d d d s d d s s s d s s p Ig p V R C Ig E P F V R C E P F G Type 1 diabetes with preserved-function B- M G T V M R T V R Borgest. Diabetes I cells. These patients were selected on the 16 14 12 10 basis of the test and may be included in 8 6 the basic research. They are most likely to 4 respond to Leptin treatment and most effectively carry out the forecast state 2 0 cd cs bd d bs s ld rd ls rs d s d d d s d d s s s d s s based on an assessment of pancreas p Ig p V R C Ig E P F V R C E P F G M G T V M R T V R biorhythms.
  • 8. Simple way of testing the organism at the level of its separate physiological systems based on an assessment of loss of symmetry. The example of the pancreas (RP) has proved that the temperature pain barrier of the right channel's branch reflects the total activity of B-cells and the left one – for A-cells This principle works at the level of all channels, due to its universal nature. А-cells
  • 9. Method of achieving quantitative assessment of the features of the principal organism. Blood sugar level assessment according to the degree of the channels’ misalignment. Test of pancreas (RP) 6 d s Right Left Norm 11 9 48 6 Typical type 1 diabetes with partial preservation of function B-cells. The presence of this atypical test asymmetry 10 24 along with high levels of blood sugar points to insulin resistance. In these patients, an increase in the level of sugar is due to the high activity of A-cells that produce the contra insulin hormone (Glyukogon). These patients will display the best responses to treatment with Leptin.
  • 10. Assessing the biorhythmic activity of organs and the physiological system Ä è í à ì è ê à î ò í î ø å í è é F ir e /W a te r _ d & F ir e /W a te r_ s â çà â è ñè ì î ñò è î ò í î ì åð à è çì åð åí è ÿ F ir e /W a te r _ d 1 F ir e /W a te r _ s 2 .0 1 .5 Y Data 1 .0 0 .5 0 .0 The biorhythmic activity of the pancreas, liver and kidneys over 38 0 2 4 6 8 1 0 1 2 1 4 1 6 1 8 2 0 2 2 2 4 2 6 2 8 3 0 3 2 3 4 3 6 3 8 X D a ta 2 3 .0 days based on the results of our 2 .5 tests. Y Data 2 .0 1 .5 1 .0 0 .5 0 .0 0 2 4 6 8 1 0 1 2 1 4 1 6 1 8 2 0 2 2 2 4 2 6 2 8 3 0 3 2 3 4 3 6 X D a ta 3 3 .0 2 .5 Y Data 2 .0 1 .5 1 .0 0 .5 0 .0 0 2 4 6 8 1 0 1 2 1 4 1 6 1 8 2 0 2 2 2 4 2 6 2 8 3 0 3 2 3 4 3 6 3 8 4 0 4 2 4 4 X D a ta
  • 11. The principal of generating biorhythms in the organ and its channel ∆t>0 Norm The organ does not work ∆t=0
  • 12. Basic principals of working system - prognosis of condition organ Real gauging Biorhythm Prognosis real time at this moment
  • 13. Basic principal of working system - prognosis of the condition of organs MODEL: glucose = 8,6xRpd – 2,3xVBs At different times of the day, due to the varied activity of organs under the action of biorhythms, the blood sugar level also changes. When estimating a biorhythm, it is possible to predict the change in sugar for the next 1-2 days. T1 T2 Rp=5 Rp=8 Vbs=16 Vbs=20 Sugar=6мМoll/l Sugar=23 мМоll/l
  • 14. The device functions over a GPRS-connection - The device works as an organiser with the creation of an optimum lifecycle for patients with, for example, diabetes. - The device indicates and forecasts blood sugar levels for the current IR- sensor for day by means of a real time diagram. The sugar level is shown not in control and digits but by the thickness of colour on the coloured scale, which makes it easier for a patient to use and understand the information treatment - The system indicates an optimum dose of insulin and the time of injection. - The optimum time for a meal is defined with the help of an estimation of the biorhythms of certain organs and is shown on a screen. - Measurements are made by touching certain acupoints on the fingers sugar- level and toes using the special gauge with IR sensor
  • 15. The concept of displaying the information to the user The screen does not Diabetes 1 type show absolute Sugar numerical values of glucose. The level of Norma glucose is shown on a colour scale of varying intensity, as on the diagram. Thus, the - + device is not a means high level of metrology, and only low level shows the tendency in sugar change (much, very much or a little). SP SP As required, the user is able to place individual Left Right marks on the screen. Furthermore, as soon as a set of sufficient Sugar prediction statistics is available, the device can be + positioned individually as a glucometer. Norma - 12:30 Time 15
  • 16. The concept of displaying the information to the user Type 2 diabetes Sugar Norma - + LI LIV GB Left ST SI The activity of each organ in an LIV GB individual model contributes to the DI formation of blood sugar levels. Right Sugar prediction + Norma - 12:30 Time 16
  • 17. The concept of displaying the information to the user Type 1 diabetes First type diabetes. Influence of insulin doze. Sugar prediction + Norma The device can be equipped with - a system for calculating an optimum dose of insulin and the Time time of optimum introduction. 5 units 5 units Diagrams of influence of different doses can be submitted to the user and to his/her doctor for download from the internet. This allows one doctor to supervise Time the condition of 30-40 patients through the special PC 10 units 10 units programme on a daily basis. 8:00 12:30 14:00 Time
  • 18. System pulse - diagnosis on the basis of three-dimensional analysis of the heart rhythm Further development of the system In the past, Chinese doctors defined the conditions of various organs on the basis of pulse diagnosis. We can also do this by means of pulse diagnosis using a measurement of temperature sensitivity. We developed this system 12 years ago, but its realisation at the time was dependent on a powerful computer and specialised knowledge. Now, the modern mobile phone allows basic calculations to be performed, with periodic transmission of data to a server. Thus, if this principle is realised, the information concerning the activity of different organs will be transmitted to the phone via sensors measuring heart contractions (for example from a special watch (“POLAR”) for controlling the heart rhythm). These data will be processed on individual models on the basis of periodic calibration of the system. In this case, the activity of the channels will be continuously estimated in real time, without the need for frequent gauging. Rhythm of heart contractions The special 3D spectral analysis of heart rhythm.
  • 19. Heart rhythm spectral component estimation system Diagram of organ activity over time Numerical value of organ activity at the present time