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AVIATION PHYSIOLOGY
The Scientific Foundation of
  Air Medical Transport

     Blair Munford, FANZCA
   NRMA CareFlight/New South
   Wales Medical Retrieval Service
Aviation Physiology and
         Critical Care Transport
           RELEVANT TO:
q Mode of Transport
    – Road vs rotorwing vs fixed wing
q Patient Selection
q Patient Treatment
q Aircrew Issues
    – Risks, precautions, fitness to fly.

                      NRMA CareFlight       2
Aviation Medicine vs Aeromedicine
         vs Air Medicine

                A V IA T IO N P H Y S IO L O G Y



      A V IA T IO N                                 A IR
      M E D IC IN E                             M E D IC IN E


     O c c u p a t io n a l                C r itic a l C a r e &
          H e a lt h                   E m e r g e n c y M e d ic in e



                              NRMA CareFlight                            3
Stresses of Flight

q Hypoxia             q Immobility
q Dysbarism           q Motion sickness
q Thermal stress      q Spacial Disorientation
q Dehydration         q Third Spacing
q Noise               q Anxiety
q Vibration           q Dystemporism
q G forces            q Fatigue


                   NRMA CareFlight         4
FOUR GAS LAWS

q   Boyles Law                q Henry’s Law
      P1V1 = P2V2              Cdissolved = k.Pgaseous
      Trapped Gas             Evolved Gas Disorders
         Disorders
                              q   Charles’ Law
qDalton’s Law                      V1/V2 = T1/T2
Ptot = P1 + P2 . . . + Pn               (or Blair’s
       Hypoxia!                         modification)
                                       P.V = k.T
                     NRMA CareFlight                    5
THE ATMOSPHERE: Physical
q TROPOSPHERE: 0 (SL) -15,000m
    – Contains clouds. Temperature falls with
      altitude.
q   STRATOSPHERE: 15,000 - 50,000m
    – Includes ozone layer
q   MESOSPHERE: 50,000 - 80,000m
    (50-80km)
q   IONOSPHERE: 80 - 650 km
    – UV & gamma irradiation produces ions
q   EXOSPHERE: 650 - 9,500 km.
                    NRMA CareFlight             6
The Earth’s Atmosphere




        NRMA CareFlight   7
AVIATION PHYSIOLOGY EXAM?
 Q1. Identify the four components of the atmosphere.


                                       Air, Clouds,
                                       Birds, &
                                       Helicopters?




                     NRMA CareFlight                   8
THE ATMOSPHERE:
     Chemical
GAS     % OF ATM              P (SL)

 N2       78%               593mm Hg

 O2      20.95%             160mm Hg

 Ar       0.9%               7mm Hg

Other    0.05%              0.35mm Hg



          NRMA CareFlight               9
ALTITUDE TABLE
Altitude Pressure  pO2   Temp              Volume
 (feet) (mm Hg) (mm Hg) (Celcius)          Change
   SL      760    159     15.0               ---
 1000     733      153             13.0     3.1%
 2000     706      148             11.0     7.6%
 4000     656      137             7.1     15.8%
 7000     586      122             1.2     29.7%
10,000    523      110             -4.8     45%
20,000    349       73             -24.6    117%


                 NRMA CareFlight                    10
THE ATMOSPHERE:
             Physiological
q   Efficient (Physiological) zone
    – 0-12,000’ (0-4000m) Pb 760 - 480 mmHg
q   (Physiological) Deficiency zone
    – 12-45,000’ Pb 480 - 110 mmHg
q   Partial Space Equivalent Zone
    – 45-600,000’. Pressurisation mandatory
q   Total Space Equivalent Zone
    – >600,000’ (200km). Weightlessness
                    NRMA CareFlight           11
HYPOXIA
“The Hidden Enemy of Air Medical Transport”




q   PATIENTS                       q   AIRCREW




                 NRMA CareFlight                 12
CLASSIFICATION OF HYPOXIA

     q   Hypoxic Hypoxia

     q   Anaemic Hypoxia

     q   Stagnant Hypoxia

     q   Histotoxic Hypoxia

              NRMA CareFlight   13
EFFECTS OF HYPOXIA

q   CENTRAL NERVOUS SYSTEM
    – Progressive dysfunction starting with
      retina & higher centres.
q   RESPIRATORY SYSTEM
    – Increased MV with decreased PaCO2.
q   CARDIOVASCULAR SYSTEM
    – HR increases followed by peripheral
      vasoconstriction & cerebral vasodilatation

                    NRMA CareFlight                14
STAGES OF HYPOXIA

q   INDIFFERENT                       q   DISTURBANCE
    <10,000’, SaO2>90%                     15-20,000’ SaO2 70-80%
    HR & RR increase                       Compensatory failure
    Effect on night vision                 Significant CNS changes

q   COMPENSATED                       q   CRITICAL
    10-15,000’ SaO2 80-90%                 20,000’+ SaO2 <70%
    CO & sBP rise                          Rapid onset of coma &
    CNS symptoms                             seizures; death likely.

                             NRMA CareFlight                      15
OXYGEN THERAPY

q   ALVEOLAR GAS EQUATION

     PAO2 = PiO2 - PACO2 / R + F

q   FiO2 CALCULATION

      FiO2(2) = FiO2(1) x P1 / P2

               NRMA CareFlight      16
DYSBARISM

q   TRAPPED GAS DISORDERS

         (Boyles Law)

q   EVOLVED GAS DISORDERS

         (Henry’s Law)

          NRMA CareFlight   17
TRAPPED GAS DISORDERS

 q   Physiological Air Spaces

 q   Pathological Air Spaces

 q   Technological Air Spaces
            (Equipment)



             NRMA CareFlight    18
Trapped Gas Disorders I:
            “Physiological”

q   Barotitis Media           q   Barodentalgia
    – Ascending squeeze            – Ascending squeeze
    – Descending squeeze             only


q   Barosinusitis             q   Baroenteralgia
    – Ascending squeeze            – Ascending squeeze
    – Descending squeeze             only



                      NRMA CareFlight                    19
Trapped Gas Disorders II:
     “Pathological”
   q Intracranial air
   q Open eye injury
   q Pneumothorax
   q Emphysema/bullae/
     asthma
   q Bowel obstruction or
     rupture

          NRMA CareFlight   20
Trapped Gas Problems with
             Equipment
q Endotracheal/tracheostomy tube cuffs
q Sengstarken-Blakemore tubes
q Swann-Ganz balloons
q Pneumatic antishock garments (MAST)
q Air splints
q Drainage bags
    – Nasogastric/intercostal/colostomy

                   NRMA CareFlight        21
EVOLVED GAS DISORDERS

q   Remember Henry’s Law

q   Problem is dissolved N2
              (1.0 -1.5 L)

q   Requires decompression
    –   Abrupt : Universal risk
    –   Planned : At risk individuals only
                  NRMA CareFlight            22
RISK FACTORS FOR
EVOLVED GAS DISORDERS
 q DIVING (& Hyperbaric
   training)
 q Prolonged altitude exposure
 q Obesity
 q Alcohol
 q Dehydration
 q Cold


            NRMA CareFlight      23
DECOMPRESSION SICKNESS

         Effects include:
 q Joints
     – “The Bends”
 q Skin - Bariobariatrauma
 q Central Nervous System
 q Arterial Gas Embolism !!!
     – “The chokes” - abrupt
       decompression
               NRMA CareFlight   24
CABIN PRESSURISATION I:
       PRINCIPLES
q Applicable to fixed wing only
q   Partial defense against:
    – Hypoxia
    – Dysbarism
q Creates artificial “Cabin Altitude”
q Cabin altitude dependant on:
    – Actual altitude
    – Maximal pressure differential
                  NRMA CareFlight       25
CABIN PRESSURISATION I:
          CALCULATIONS
q   Example I - Lear 35
    Maximum cabin pressure differential 430mm Hg
     So @ 40,000’ (=141 mm Hg) can maintain cabin
     altitude of 570 mmHg = 8000’

q   Example II - King Air 200.
    Sea level cabin altitude requested. Max cabin
      pressure differential = 350 mm Hg. So can fly
      at 410 mm Hg = 16,000’
                      NRMA CareFlight           26
THERMAL STRESS I: PRINCIPLES
q Remember mechanisms of heat loss:
             CONVECTION
             CONDUCTION
            EVAPORATION
               RADIATION
q Outside air temperature
    – drops 2 degrees C per 1000’ rise
q   Helo patients also at risk of temp rise
                    NRMA CareFlight           27
THERMAL STRESS I:
    Special Risk Patients
q Paralysed/Sedated
q Intoxicated
q Polyinfused/transfused
q Immersion or other wet
q Pre existing hypothermia
q Burns patients
q Prolonged transports


           NRMA CareFlight   28
HUMIDITY & DEHYDRATION
q Water vapour content falls with
  increasing altitude & decreasing temp.
q Pressurised aircraft has WVP of outside
  pressure not cabin pressure
              EFFECTS ON
q RESPIRATORY SYSTEM
q Other mucus membranes
q Endocrine/renal/CVS axis

                 NRMA CareFlight        29
NOISE

q Major hinderance to patient care
q Level: Helo > Fixed wing > Road
q Noise interferes with
    – Communication
    – Patient assessment - e.g auscultation
q   Hearing protection & communications
    technology mandatory in helicopter.

                     NRMA CareFlight          30
VIBRATION
q   Interferes with:
    –   Patient comfort
    –   Metabolic Rate (increases)
    –   Equipment: NIBP, SaO2, etc.
q   Vibration levels:
    Road(bad) > Helo > FW take off > Road (good)
    > FW cruise
q   Vibration minimisation
    – Passive vs active
                          NRMA CareFlight      31
GRAVITATIONAL FORCES

q Levels of G force experienced:
     1. Road vehicle (brake/swerve)
     2. Fixed wing takeoff & landing
     3. Road vehicle (normal driving)
     4. Fixed wing climb/cruise/descent
     5. Helicopter (all normal ops)
q Positioning may minimise effects

                NRMA CareFlight       32
SPACIAL DISORIENTATION

“INCORRECT PERCEPTION OF
  POSITION, MOTION OR ATTITUDE”

Due to absent or incorrect input from one
                or more of:
q Visual system
q Vestibular apparatus
q Proprioceptive apparatus
                NRMA CareFlight         33
MOTION SICKNESS
q Variable susceptibility
    Precipitating factors include:
q Turbulence
q Spatial disorientation
q Hot/stuffy environment
q Hunger or oversatiation
q Fear or unpleasant stimuli
q Medications


              NRMA CareFlight        34
“THIRD SPACING”
q Fluid leakage into interstitium
q Increased during transport
q Multifactorial
    –   VIBRATION
    –   G forces
    –   Temperature
q   Effects include:
    – Oedema/swelling under casts
    – Effective dehydration/hypovolaemia
                       NRMA CareFlight     35
DYSTEMPORISM
q Common name: “jet lag”
q Occurs with transmeridian travel
q Disturbance of circadian rhythm
q Sun following (westward) versus sun
  shortening (eastward) travel.
q Influenced by: activity/food/alcohol
q Hypnotics for sleep restoration:
    – Temazepam vs oxazepam

                 NRMA CareFlight         36
FATIGUE I: THE PROBLEM
q Fatigue itself is a stressor
q Fatigue is also the common point of
  other stressors.
q Fatigue affects judgement & perception
    – INCLUDING OF FATIGUE ITSELF
q   Air medical crew fatigue is a potential
    killer:
    –   OF PATIENTS
    –   OF AIRCREW
                   NRMA CareFlight        37
FATIGUE I:
 THE RISK FACTORS
q Remember the avoidable:
       D*E*A*T*H
q Drugs
q Exhaustion
q Alcohol
q Tobacco
q Hypoglycaemia

         NRMA CareFlight    38
SUMMARY

q All medical transport including by air
  creates a sub optimal environment.
q Many patients may be at risk from this
  exposure.
q The challenge is to provide optimal care
   in spite of the environment
q Knowledge of the environment is the
  key to achieving this.
                 NRMA CareFlight        39
THE END

Any Questions?

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Aviation Medicine

  • 1. AVIATION PHYSIOLOGY The Scientific Foundation of Air Medical Transport Blair Munford, FANZCA NRMA CareFlight/New South Wales Medical Retrieval Service
  • 2. Aviation Physiology and Critical Care Transport RELEVANT TO: q Mode of Transport – Road vs rotorwing vs fixed wing q Patient Selection q Patient Treatment q Aircrew Issues – Risks, precautions, fitness to fly. NRMA CareFlight 2
  • 3. Aviation Medicine vs Aeromedicine vs Air Medicine A V IA T IO N P H Y S IO L O G Y A V IA T IO N A IR M E D IC IN E M E D IC IN E O c c u p a t io n a l C r itic a l C a r e & H e a lt h E m e r g e n c y M e d ic in e NRMA CareFlight 3
  • 4. Stresses of Flight q Hypoxia q Immobility q Dysbarism q Motion sickness q Thermal stress q Spacial Disorientation q Dehydration q Third Spacing q Noise q Anxiety q Vibration q Dystemporism q G forces q Fatigue NRMA CareFlight 4
  • 5. FOUR GAS LAWS q Boyles Law q Henry’s Law P1V1 = P2V2 Cdissolved = k.Pgaseous Trapped Gas Evolved Gas Disorders Disorders q Charles’ Law qDalton’s Law V1/V2 = T1/T2 Ptot = P1 + P2 . . . + Pn (or Blair’s Hypoxia! modification) P.V = k.T NRMA CareFlight 5
  • 6. THE ATMOSPHERE: Physical q TROPOSPHERE: 0 (SL) -15,000m – Contains clouds. Temperature falls with altitude. q STRATOSPHERE: 15,000 - 50,000m – Includes ozone layer q MESOSPHERE: 50,000 - 80,000m (50-80km) q IONOSPHERE: 80 - 650 km – UV & gamma irradiation produces ions q EXOSPHERE: 650 - 9,500 km. NRMA CareFlight 6
  • 7. The Earth’s Atmosphere NRMA CareFlight 7
  • 8. AVIATION PHYSIOLOGY EXAM? Q1. Identify the four components of the atmosphere. Air, Clouds, Birds, & Helicopters? NRMA CareFlight 8
  • 9. THE ATMOSPHERE: Chemical GAS % OF ATM P (SL) N2 78% 593mm Hg O2 20.95% 160mm Hg Ar 0.9% 7mm Hg Other 0.05% 0.35mm Hg NRMA CareFlight 9
  • 10. ALTITUDE TABLE Altitude Pressure pO2 Temp Volume (feet) (mm Hg) (mm Hg) (Celcius) Change SL 760 159 15.0 --- 1000 733 153 13.0 3.1% 2000 706 148 11.0 7.6% 4000 656 137 7.1 15.8% 7000 586 122 1.2 29.7% 10,000 523 110 -4.8 45% 20,000 349 73 -24.6 117% NRMA CareFlight 10
  • 11. THE ATMOSPHERE: Physiological q Efficient (Physiological) zone – 0-12,000’ (0-4000m) Pb 760 - 480 mmHg q (Physiological) Deficiency zone – 12-45,000’ Pb 480 - 110 mmHg q Partial Space Equivalent Zone – 45-600,000’. Pressurisation mandatory q Total Space Equivalent Zone – >600,000’ (200km). Weightlessness NRMA CareFlight 11
  • 12. HYPOXIA “The Hidden Enemy of Air Medical Transport” q PATIENTS q AIRCREW NRMA CareFlight 12
  • 13. CLASSIFICATION OF HYPOXIA q Hypoxic Hypoxia q Anaemic Hypoxia q Stagnant Hypoxia q Histotoxic Hypoxia NRMA CareFlight 13
  • 14. EFFECTS OF HYPOXIA q CENTRAL NERVOUS SYSTEM – Progressive dysfunction starting with retina & higher centres. q RESPIRATORY SYSTEM – Increased MV with decreased PaCO2. q CARDIOVASCULAR SYSTEM – HR increases followed by peripheral vasoconstriction & cerebral vasodilatation NRMA CareFlight 14
  • 15. STAGES OF HYPOXIA q INDIFFERENT q DISTURBANCE <10,000’, SaO2>90% 15-20,000’ SaO2 70-80% HR & RR increase Compensatory failure Effect on night vision Significant CNS changes q COMPENSATED q CRITICAL 10-15,000’ SaO2 80-90% 20,000’+ SaO2 <70% CO & sBP rise Rapid onset of coma & CNS symptoms seizures; death likely. NRMA CareFlight 15
  • 16. OXYGEN THERAPY q ALVEOLAR GAS EQUATION PAO2 = PiO2 - PACO2 / R + F q FiO2 CALCULATION FiO2(2) = FiO2(1) x P1 / P2 NRMA CareFlight 16
  • 17. DYSBARISM q TRAPPED GAS DISORDERS (Boyles Law) q EVOLVED GAS DISORDERS (Henry’s Law) NRMA CareFlight 17
  • 18. TRAPPED GAS DISORDERS q Physiological Air Spaces q Pathological Air Spaces q Technological Air Spaces (Equipment) NRMA CareFlight 18
  • 19. Trapped Gas Disorders I: “Physiological” q Barotitis Media q Barodentalgia – Ascending squeeze – Ascending squeeze – Descending squeeze only q Barosinusitis q Baroenteralgia – Ascending squeeze – Ascending squeeze – Descending squeeze only NRMA CareFlight 19
  • 20. Trapped Gas Disorders II: “Pathological” q Intracranial air q Open eye injury q Pneumothorax q Emphysema/bullae/ asthma q Bowel obstruction or rupture NRMA CareFlight 20
  • 21. Trapped Gas Problems with Equipment q Endotracheal/tracheostomy tube cuffs q Sengstarken-Blakemore tubes q Swann-Ganz balloons q Pneumatic antishock garments (MAST) q Air splints q Drainage bags – Nasogastric/intercostal/colostomy NRMA CareFlight 21
  • 22. EVOLVED GAS DISORDERS q Remember Henry’s Law q Problem is dissolved N2 (1.0 -1.5 L) q Requires decompression – Abrupt : Universal risk – Planned : At risk individuals only NRMA CareFlight 22
  • 23. RISK FACTORS FOR EVOLVED GAS DISORDERS q DIVING (& Hyperbaric training) q Prolonged altitude exposure q Obesity q Alcohol q Dehydration q Cold NRMA CareFlight 23
  • 24. DECOMPRESSION SICKNESS Effects include: q Joints – “The Bends” q Skin - Bariobariatrauma q Central Nervous System q Arterial Gas Embolism !!! – “The chokes” - abrupt decompression NRMA CareFlight 24
  • 25. CABIN PRESSURISATION I: PRINCIPLES q Applicable to fixed wing only q Partial defense against: – Hypoxia – Dysbarism q Creates artificial “Cabin Altitude” q Cabin altitude dependant on: – Actual altitude – Maximal pressure differential NRMA CareFlight 25
  • 26. CABIN PRESSURISATION I: CALCULATIONS q Example I - Lear 35 Maximum cabin pressure differential 430mm Hg So @ 40,000’ (=141 mm Hg) can maintain cabin altitude of 570 mmHg = 8000’ q Example II - King Air 200. Sea level cabin altitude requested. Max cabin pressure differential = 350 mm Hg. So can fly at 410 mm Hg = 16,000’ NRMA CareFlight 26
  • 27. THERMAL STRESS I: PRINCIPLES q Remember mechanisms of heat loss: CONVECTION CONDUCTION EVAPORATION RADIATION q Outside air temperature – drops 2 degrees C per 1000’ rise q Helo patients also at risk of temp rise NRMA CareFlight 27
  • 28. THERMAL STRESS I: Special Risk Patients q Paralysed/Sedated q Intoxicated q Polyinfused/transfused q Immersion or other wet q Pre existing hypothermia q Burns patients q Prolonged transports NRMA CareFlight 28
  • 29. HUMIDITY & DEHYDRATION q Water vapour content falls with increasing altitude & decreasing temp. q Pressurised aircraft has WVP of outside pressure not cabin pressure EFFECTS ON q RESPIRATORY SYSTEM q Other mucus membranes q Endocrine/renal/CVS axis NRMA CareFlight 29
  • 30. NOISE q Major hinderance to patient care q Level: Helo > Fixed wing > Road q Noise interferes with – Communication – Patient assessment - e.g auscultation q Hearing protection & communications technology mandatory in helicopter. NRMA CareFlight 30
  • 31. VIBRATION q Interferes with: – Patient comfort – Metabolic Rate (increases) – Equipment: NIBP, SaO2, etc. q Vibration levels: Road(bad) > Helo > FW take off > Road (good) > FW cruise q Vibration minimisation – Passive vs active NRMA CareFlight 31
  • 32. GRAVITATIONAL FORCES q Levels of G force experienced: 1. Road vehicle (brake/swerve) 2. Fixed wing takeoff & landing 3. Road vehicle (normal driving) 4. Fixed wing climb/cruise/descent 5. Helicopter (all normal ops) q Positioning may minimise effects NRMA CareFlight 32
  • 33. SPACIAL DISORIENTATION “INCORRECT PERCEPTION OF POSITION, MOTION OR ATTITUDE” Due to absent or incorrect input from one or more of: q Visual system q Vestibular apparatus q Proprioceptive apparatus NRMA CareFlight 33
  • 34. MOTION SICKNESS q Variable susceptibility Precipitating factors include: q Turbulence q Spatial disorientation q Hot/stuffy environment q Hunger or oversatiation q Fear or unpleasant stimuli q Medications NRMA CareFlight 34
  • 35. “THIRD SPACING” q Fluid leakage into interstitium q Increased during transport q Multifactorial – VIBRATION – G forces – Temperature q Effects include: – Oedema/swelling under casts – Effective dehydration/hypovolaemia NRMA CareFlight 35
  • 36. DYSTEMPORISM q Common name: “jet lag” q Occurs with transmeridian travel q Disturbance of circadian rhythm q Sun following (westward) versus sun shortening (eastward) travel. q Influenced by: activity/food/alcohol q Hypnotics for sleep restoration: – Temazepam vs oxazepam NRMA CareFlight 36
  • 37. FATIGUE I: THE PROBLEM q Fatigue itself is a stressor q Fatigue is also the common point of other stressors. q Fatigue affects judgement & perception – INCLUDING OF FATIGUE ITSELF q Air medical crew fatigue is a potential killer: – OF PATIENTS – OF AIRCREW NRMA CareFlight 37
  • 38. FATIGUE I: THE RISK FACTORS q Remember the avoidable: D*E*A*T*H q Drugs q Exhaustion q Alcohol q Tobacco q Hypoglycaemia NRMA CareFlight 38
  • 39. SUMMARY q All medical transport including by air creates a sub optimal environment. q Many patients may be at risk from this exposure. q The challenge is to provide optimal care in spite of the environment q Knowledge of the environment is the key to achieving this. NRMA CareFlight 39