1. NYEX 2011 Conference, 13-16 March Judea, Israel TALENTED STUDENTS AND MOTIVATED TEACHERS: AN INTERACTIVE AND SYNERGISTIC TANDEM TO DESIGN INNOVATIVE HANDS-ON LEARNING PRACTICES IN BIOLOGY Giovanna Viale and Cinzia Grazioli CusMiBio, Milan – Italy

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5. NYEX 2011 Conference, 13-16 March Judea, Israel OPPORTUNITIES FOR TALENTED YOUNG PEOPLE IN BIOSCIENCES Promote students’ investigation experiences ...I’m not so sure!!! Can I have a look too ?

6. NYEX 2011 Conference, 13-16 March Judea, Israel CUSMIBIO “ FROM MANY TO FEW” An opportunity for all students. Reach the largest possible number of students attending all types of high schools A challenge for the most talented. Selected actions envisaged for the most gifted students

7. NYEX 2011 Conference, 13-16 March Judea, Israel CUSMIBIO “ FROM MANY TO FEW” An opportunity for all students.

8. NYEX 2011 Conference, 13-16 March Judea, Israel CUSMIBIO “ FROM MANY TO FEW”

9. NYEX 2011 Conference, 13-16 March Judea, Israel CUSMIBIO HAS DEDICATED LABS IN THE MILAN STATE UNIVERSITY CAMPUS These labs are an integral part of the Lombardy school system

11. NYEX 2011 Conference, 13-16 March Judea, Israel Since 2009 CusMiBio has been appointed by the Italian Ministry of Education as reference centre for the valorization of talented High School students

12. Selected actions envisaged for the most gifted students A WEEK AS A RESEARCHER NYEX 2011 Conference, 13-16 March Judea, Israel

15. NYEX 2011 Conference, 13-16 March Judea, Israel From CusMiBio to School Kits (materials, handbook, protocols, teacher guide etc..) that can be “hired” from CusMiBio and taken to school . FROM SCHOOL TO UNIVERSITY: A ROUND TRIP From School to CusMiBio Try the biolab: hands-on activities for High Schoo l students at the CusMiBio Laboratories

16. NYEX 2011 Conference, 13-16 March Judea, Israel AN INTERACTIVE AND SYNERGISTIC TANDEM TO DESIGN INNOVATIVE HANDS-ON LEARNING PRACTICES IN BIOLOGY The most motivated and skilled students , identified through selective competitions, are invited together with their teachers to set-up KITS and learning modules adapted to be transferred to their schools. Both are actors of the project. Together they develop the theoretical and practical activities to be proposed to their peers A positive reciprocal feedback

18. NYEX 2011 Conference, 13-16 March Judea, Israel ‘ learning by teaching’ strategy: you learn a lot when you have to teach others

19. NYEX 2011 Conference, 13-16 March Judea, Israel students’ own knowledge and confidence grows as they pass on their knowledge and experiences

20. NYEX 2011 Conference, 13-16 March Judea, Israel Moreover… students have an opportunity to develop a wide range of complementary skills , such as work in groups, peer exchange abilities, communication with an appropriate language whether the students taught by the tutors benefit is yet to be evaluated. FROM SCHOOL to UNIVERSITY: A ROUND TRIP RESULTS: Students (2)

23. NYEX 2011 Conference, 13-16 March Judea, Israel The collaboration starts during the training courses where the different stake-holders, i.e. scientists, student and their teachers come in close contact. Scientists have agreed to mentor classroom teachers and students through these courses. TRAINING FOR TEACHERS AND THEIR STUDENTS How to use the kits at school

24. WHO IS THE CULPRIT?

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28. NYEX 2011 Conference, 13-16 March Judea, Israel FLASH GEL SYSTEM 5 min separation & recovery … find the culprit

29. YEAST : HONORARY MAMMAL

31. NYEX 2011 Conference, 13-16 March Judea, Israel NB: All materials must be returned to CusMiBio. Mishandling, breakage or missing instruments costs will be borne by the school. All materials provided in the kit, if correctly handled, don’t pose risks and conform to safety standards. For further information, check the instructions in the kit. EACH KIT COMES WITH THE LIST OF MATERIALS

32. CHROMOSOME ANALYSIS

34. FISH NYEX 2011 Conference, 13-16 March Judea, Israel Fluorescent in situ hybridization Magnetic bars + iron beads serving as probes!! FISH is suitable for gene mapping and for the identification of small chromosomal aberrations involving a single gene, not visible by cytogenetics.

35. NYEX 2011 Conference, 13-16 March Judea, Israel HOW TO IDENTIFY SPECIFIC GENES ON CHROMOSOMES? HOW TO IDENTIFY SMALL CHROMOSOMAL ABERRATIONS INVOLVING SINGLE GENES? The use of a model simulating FISH allows the students to acquire the basic principles of this technique and to appreciate its high resolution power.

36. NYEX 2011 Conference, 13-16 March Judea, Israel Deletion of a small chromosome region Fluorescent in situ hybridization (FISH) Real FISH Simulated FISH

37. VIRTUAL MICROARRAYS

38. NYEX 2011 Conference, 13-16 March Judea, Israel RED LIGHT GENES ……… and N O T ONL Y R E D VIRTUAL MICROARRAYS (Initially developed at EMBL-ELLS labs, Heidelberg)

39. NYEX 2011 Conference, 13-16 March Judea, Israel VIRTUAL MICROARRAYS To visualize gene expression a custom-made mat, Velcro and torches are used, following step by step the microarray technology and learning about its possible future applications.

41. NYEX 2011 Conference, 13-16 March Judea, Israel Thank you! website: www.cusmibio.unimi.it e-mail: cusmibio@unimi.it

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