2. Goal: To delineate drug discovery opportunities in a field of interest to multiple pharmaceutical companies utilizing structured data searching software for the Drug Discovery Center of Innovation and identify Chinese gateways for The Hamner Institute Field: Oncology – Pathways that regulate the fate of cancer stem cells
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4. What is the value of VantagePoint? 1 day 1 second Data Retrieval Speed Fast Slow Company Affiliations Yes No Quick Identification of Targets Yes No Author Networks Yes No Region Specificity 253 1,280,000+ Number of Records Search: “ Novel oncology target” Worldwide 2008-2010 data
5. Process: Team: Pete Geisen, Brian Ridout, Jonathan Dancy Tools: VantagePoint software (version 6.1) Query Journal Databases (Pubmed, Web of Science) Data collection – duplicate identification and removal Data Collection Quality Control Identification of Major Authors in each sub-field (eg. methods, compounds, etc) Discovery of specific novel targets, methods and compounds using pattern recognition Additional Search Terms and QC
6. Search Terms Cancer + Stem Cancer + Stem + Cells Cancer + Progenitor Stem + Cell(s) + Biology Stem + Cell(s) + Targeted + Therapy Subpopulation + Cells Self-renewal Method + Cancer + Isolation Quality Control Cancer + Stem Cancer + Progenitor 13,586 records China USA Unique Targets Novel Compounds Novel Models/ Assays (933 records) (5,843 records) Objectives: Identify research conducted since 2008 Databases Medline (Pubmed) Web of Science Unique Targets Novel Compounds Novel Models/ Assays (37) (8) (15) (247) (67) (89)