Sean Ekins (Collaborative Drug Discovery) provides an overview of this potential Pistoia Alliance project during the "Dragons' Den" session at the Pistoia Alliance Conference in Boston, MA, on April 24, 2012.

1. Open Drug
Discovery Teams
(ODDT)
http://slidesha.re/xzGhFH

2. A New Challenge
 Mid January Pistoia Alliance ask for volunteers
to present in a Dragon’s Den scenario Feb 8th at
the RSC
 Ideas that will transform Pharma R&D in 2014
 So my natural response was :
“If I am going to take part I want to create
something real”
http://bit.ly/wImJtH
http://pistoiaalliance.org/

3. Could an app transform R&D ?
 Tuberculosis Kills 1.6-1.7m/yr (~1 every 8 seconds) equivalent to malaria
 No new drugs in over 40 yrs
 Pipeline is thin and weak BMGF & NIH do not coordinate TB efforts, not
mandating open data.
 > 7000 rare diseases
 e.g. Jill Wood started a foundation, raises money, awareness, funds
ground breaking research happening globally.
 She is in a race against time – what can we do to translate ideas from
bench to patient faster?
 How can we help parents and families ?

4. Inspiration
 There are many 1000s of diseases
and few with cures
 Science Online 2012 on open notebooks and data
overload
 Flipboard
 Could we create an app
for science like Flipboard?

5. http://slidesha.re/why7gg

6. Within about 10 days Alex Clark Created
ODDT to present at the Pistoia meeting
Focused on Tuberculosis, Malaria, HIV/AIDS, Huntington’s Disease,
Sanfilippo Syndrome, and Green Chemistry as topics in version 1
We did not win the competition but had useful feedback – the need to
articulate the value proposition
http://slidesha.re/GzVSPr

7. The Value Proposition
 The project is intended to bring together open data in a single aggregated
collection, and then facilitate forming open research teams around this data
 Disseminate important information to a highly relevant target audience
 Network and discover other researchers with complementary interests, and
opportunities to collaborate
 Team members will be able to borrow and reuse a growing collection of
existing Open data.
 The community as a whole can debate, contest or endorse data based on
its quality.
 The app could also be used as a type of “lab notebook” whereby individual
researchers share links (URLs) to content and the app aggregates these.
http://slidesha.re/weDFLg

8. Latest Layout
9 Panels includes one
on ODDT information
Can use multiple
Twitter accounts
Here is my icon
Stats summary
About App

9. Tap on a panel and look at
Incoming contents
Click here to
endorse or
disapprove
Click here to
follow hyperlink
Incoming is
sorted by time
of creation

10. Browse through multiple pages of
tweets

11. Endorse, Disapprove and
Comment

12. Recent contents
Click on image to
open it
Recent is
factoids with
a vote count
of +1 or
better

13. Content Click on image to
open it
Ranked content
Content is
currently
anything with
a vote
count of +1 or
better, sorted
by most
popular first

14. Tap on a link or image

15. Be able to download
content

16. Look at your own statistics

17. Exposing rare diseases – creating
communities of researchers and sparking
discussion
My tweets on
recent analyses
and ideas
My Retweets

18. Coming Soon
 From idea to appstore in ~2 months
 Available on appstore since April 12
 Future versions will allow user to specify topics
 Presented at ACS
 Submitted business plan to ACS GCI
 Rewards – badges
 Beta version
 More ideas that may need funding to cover server
etc
 - Would you fund us if we posted ODDT on
Kickstarter or Petridish.org or IndieGoGo??
 Are there sponsors for specific pages or content?

19. Thank you Alpha
testers
 Antony J. Williams
 Hans De Winter
 Chris Swain
 Andrew Lang
 Carlo Yuvienco
 Paul Reinheimer
 Michael S. Lajiness
 Nancy Connell
 Greta Beekhuis
 Joe Hupcey III
 Freundlich, Joel
 Tanya Parrish
 Peter Olinga
ODDT
 Peter Caduff
Photo for San Fillipo Syndrome courtesy
of Jill Wood www.jonahsjustbegun.org

20. More Information
 Please contact us for further details or suggestions at:
aclark@molmatinf.com and ekinssean@yahoo.com
 You can learn more about the ODDT app at:
http://www.scimobileapps.com/index.php?
title=Open_Drug_Discovery_Teams
And frequent blogs at http://www.collabchem.com and
http://cheminf20.org/
User guide now available at SlideShare http://slidesha.re/JcDTOs
and FigShare http://bit.ly/IjR52V