Lecture about the benefits of the dermal implant Radiesse given at IMCAS Paris 2008 by Dr. Patrick Treacy. Learm more at http://www.ailesburyclinic.ie/

1. Clinical Research Data vs. vs.

6. Results after 1 st treatment Less volume

7. vs Restylane

8. vs Restylane

9. Comparative Study: Radiesse vs Restylane GAIS 3 Months 6 Months 9 Months 79% 44% More Patients improved with Radiesse than with Restylane Time post 2nd Injection % of Patients Improved or better (n=60 Split Face)

10. WSRS = Wrinkle Severity Rating Scale 5 Extreme Extremely deep and long folds, detrimental to facial appearance. 2-4mm Visible V-shaped fold when stretched Unlikely to have satisfactory correction with injectable implant alone. 4 Severe Very long and deep folds; prominent facial feature. Less than 2mm visible fold when stretched. Significant improvement is expected from injectable implant. 3 Moderate Moderately deep folds. Clear facial feature visible at normal appearance but not when stretched. Excellent correction is expected from injectable implant. 2 Mild Shallow but visible fold with a slight indentation; minor facial feature. Implant is expected to produce a slight improvement in appearance. 1 Absent No visible fold, continuous skin line. 1 5 4 3 2

11. GAIS = Global Aesthetic Improvement Scale Very Much Improved Optimal cosmetic result for the implant in this patient. Much Improved Marked improvement in appearance but not completely optimal for this patient. A touch-up would slightly improve the result. Improved Obvious improvement in appearance from the initial condition, but a touch-up or re-treatment is indicated. No Change The appearance is essentially the same as the original condition. Worse The appearance is worse than the original condition.

13. Comparative Study Radiesse vs Perlane vs Juvederm 24/24HV GAIS 4 Months 8 Months 12 Months More Patients improved with Radiesse than with Perlane & Juvederm Time post 2nd Injection 62% 50% 48% 88% 53% 64% % of Patients Improved or better (n=205)

14. One fold (split face) (touch up at 3 Months) Both folds (touch up at 4 Months) Radiesse 0.89 Restylane 1.26 Radiesse 2.21 Perlane 2.89 Juvederm HV 2.94 cc - including touch up Volume Comparison Syringes needed for 2 Folds Full Correction 1.4 2.5 1.7 2.9 3.7 % of Optimal Correction w/ One Syringe 70% 40% 60% 34% 27%

16. Comparative Study Radiesse vs Perlane vs Juvederm 24/24HV Patient Satisfaction More patients were Satisfied with Radiesse than with Perlane or Juvederm Time post 2nd Injection % of Patients That are Satisfied & Extremely Satisfied

17. Comparative Study: Radiesse vs Restylane Patients likely to return % of Patients who say that they are Likely or Extremely Likely to return for future treatments Patients are 3 times more likely to return for re-treatments with Radiesse Time post 2nd Injection Radiesse Restylane

18. Comparative Study Radiesse vs Perlane vs Juvederm 24/24HV Patients likely to return Patients are much more likely to come in for re-treatments with Radiesse Time post 2nd Injection % of Patients who say that they are Likely or Extremely Likely to return for future treatments

20. Acknowledgements and Participating Centers Marion Moers-Carpi , Munich, Germany Stephan Vogt , Hanover, Germany Jaime Opi Tufet , Barcelona, Spain Begonia Martinez Santos , Barcelona, Spain Jorge Planas , Barcelona, Spain Sonia Rovira Vallve , Barcelona, Spain

22. Calcium Hydroxylapatite Macrophages dissolve gel carrier & fibroblasts form new collagen. Natural mineral non-antigenic, non-irritant, non-toxic metabolizes via homeostatic mechanisms

23. Facial Augmentation Nasolabial Fold Mental crease Jaw Line Chin Post-rhinoplasty Marionette Line Cheek Malar Radial Lip Lines