14. Cerebral infarction. A, At low magnification, it is possible to see the demarcated areas of an acute infarction. In the underlying white matter, the areas of infarction are well shown by the myelin stain. B, Acute ischemic injury causes diffuse eosinophilia of neurons, which are beginning to shrink. C, infiltration of a cerebral infarct by neutrophils begins at the edges of the lesion where vascular supply has remained intact. D, After about 10 days, an area of infarction is characterized by the presence of macrophages and surrounding reactive gliosis. E, Remote small intracortical infarcts are seen as areas of tissue loss with a small amount of residual gliosis.
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22. A, Sections of the brain showing a large, discolored, focally hemorrhagic region in the left middle cerebral artery distribution (hemorrhagic, or red, infarction)
23. C, A bland infarct with punctate hemorrhages, consistent with ischemia-reperfusion injury, is present in the temporal lobe.
55. Multiple sclerosis. Section of fresh brain showing brown plaque around occipital horn of the lateral ventricle.
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59. Multiple sclerosis. A, Unstained regions of demyelination (MS plaques) around the fourth ventricle (Luxol fast blue PAS stain for myelin). B, Myelin-stained section shows the sharp edge of a demyelinated plaque and perivascular lymphocytic cuffs. C, The same lesion stained for axons shows relative preservation.
85. Alzheimer disease with cortical atrophy most evident on the right, where meninges have been removed.
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87. Alzheimer disease. A, Neuritic plaque with a rim of dystrophic neurites surrounding an amyloid core.
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90. Alzheimer Disease. B, Congo red stain of the cerebral cortex showing amyloid deposition in the blood vessels and the amyloid core of the neuritic plaque (arrow)
91. Alzheimer Disease. C, Neurofibrillary tangles (arrowheads) are present within the neurons.
133. Huntington disease (HD). Normal hemisphere on the left compared with the hemisphere with HD on the right showing atrophy of the striatum and ventricular dilation.
151. Amyotrophic lateral sclerosis. Spinal cord showing loss of myelinated fibers (lack of stain) in corticospinal tracts. The anterior roots are smaller than the posterior roots.
170. Metachromatic leukodystrphy. Demyelination is extensive. The subcortical fibers in the cerebral hemisphere are spared (Luxol fast blue PAS stain for myelin)
207. Alcoholic cerebellar degeneration. The anterior portion of the vermis (upper portion of figure) is atrophic with widened spaces between the folia.
272. A, parasagittal multilobular meningioma attached to the dura with compression of underlying brain. B, Meningioma with a whorled pattern of cell growth and psammoma bodies.
