Apps for science- Applications on ScienceDirect - protein finder and interaction network

Fuzzy net works using a multidimensional view of data have become very popular in both business and science in recent years. Fuzzy net works for fuzzy purposes such as medicine and bio-chemistry1 pose several great challenges to existing fuzzy net work technology. Fuzzy net works usually use pre-aggregated data to ensure fast query response. However, pre-aggregation cannot be used in practice if the dimension structures or the relationships between facts and dimensions are irregular. A technique for overcoming this limitation and some experimental results are presented. Queries over fuzzy fuzzy net works often need to reference data that is external to the fuzzy net work, e.g., data that is too complex to be handled by current fuzzy net work technology, data that is â€ownedâ€ by other organizations, or data that is updated frequently. This paper presents a federation architecture that allows the integration of multidimensional warehouse data with complex external data.

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Semantic web technologies offer a potential mechanism for the representation and integration of thousands of biomedical databases. Many of these databases offer cross-references to other data sources, but these are generally incomplete and prone to error. In this paper, we conduct an empirical analysis of the link structure of life science Linked Data, obtained from the Bio2RDF project. Three different link graphs for datasets, entities and terms are characterized by degree, connectivity, and clustering metrics, and their correlation is measured as well. Furthermore, we utilize the symmetry and transitivity of entity links to build a benchmark and evaluate several popular entity matching approaches. Our findings indicate that the life science data network can help find hidden links, can be used to validate links, and may offer a mechanism to integrate a wider set of resources to support biomedical knowledge discovery.

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Bio2RDF is an open-source project that offers a large and connected knowledge graph of Life Science Linked Data. Each dataset is expressed using its own vocabulary, thereby hindering integration, search, query, and browse data across similar or identical types of data. With growth and content changes in source data, a manual approach to maintain mappings has proven untenable. The aim of this work is to develop a (semi)automated procedure to generate high quality mappings between Bio2RDF and SIO using BioPortal ontologies. Our preliminary results demonstrate that our approach is promising in that it can find new mappings using a transitive closure between ontology mappings. Further development of the methodology coupled with improvements in the ontology will offer a better-integrated view of the Life Science Linked Data

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The poster was made during a 2.5 day NSF sponsored workshop on August 5th – 7th on the University of Washington, Seattle campus, which brought together 100 graduate students from diverse domain sciences and engineering with Data Scientists from industry and academia to discuss and collaborate on Big Data / Data Science challenges. In addition to keynote presentations from high profile speakers, the participants presented posters covering their own research and worked collaboratively to begin to solve some of the Grand Challenge problems facing Data Enabled Science & Engineering disciplines. This presentation was made by 10 graduate students, whose united them was high-dimensional biological data. For more info, see http://depts.washington.edu/dswkshp/

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