1. Vaccines 2012 World Market Analysis, Key Players, Trends,
Pediatric and Adult Segments
Report Details:
Published:September 2012
No. of Pages: 249
Price: Single User License – US$3995
This report examines the market for vaccines used in humans to previous various types of
disease. It covers only commercialized vaccines and developmental vaccines for diseases that are
already vaccine-preventable; it does not cover emerging vaccines for diseases that are not
currently vaccine-preventable, such as Alzheimer’s disease, diabetes, Ebola infection, Epstein-
Barr virus (EBV) infection, ETEC infection, heart attach, Helicobacter pylori infection, multiple
sclerosis, Parkinson’s disease, West Nile virus (WNV) infection, etc.; vaccines that address these
and other not-yet-vaccine-preventable conditions are discussed in Kalorama’s new report, “What's
Next in Vaccines.”
The vaccine industry has seen changes in the past year, and these are covered in this report
Vaccines 2012: World Market Analysis, Key Players, and Critical Trends in a Fast-Changing
Industry. The high growth rates and successful launch of several products recently have kept
interest in the global vaccine market high. The global market for vaccines experienced strong
growth through 2011 and this is expected to continue through the forecast period. Growth is being
fueled by new product introductions and rising usage in all regions.
Included in this report are current market size and forecast for the following vaccines:
Pediatric Vaccines:
•Combinations
•Hepatitis
•HIB
•MMR
•Pneumococcal
•Poliovirus
•Varicella
•Other Pediatric
Adult Vaccines:

2. •Cervical Cancer
•Hepatitis
•Influenza
•Pneumococcal
•Travel; DT; Misc.
Kalorama has expanded the global perspective of this report in this edition, including estimates of
vaccine sales (pediatric and adult segments) in the following regions:
•U.S.
•Rest of North Amer.
•South America
•Europe
•Japan
•India
•China
•Rest of World
Despite ongoing improvements in pediatric vaccination, it is estimated that at least two million
children die each year from diseases that could have been prevented by already existing vaccines.
This problem is most significant in low income countries, with the health disparity between rich and
poor countries resulting in average life spans of about 77 and 52 years, respectively. In addition to
this high death toll, millions more suffer disability and illness because they have not been
immunized. Adult immunization is an important, but frequently overlooked, part of patient care.
Vaccination programs typically focus on children, yet adults in industrialized countries are more
likely to die as a result of vaccine-preventable diseases than are children.
Key issues in the global vaccine market today include product safety, refusal to immunize, supply
shortages, the use of vaccines to prevent pandemics and address bioterrorism, and innovations in
vaccine delivery systems.The following issues are discussed in this report.
•Vaccine Safety
•Refusal to Immunize
•Obesity
•Post-Licensure Surveillance
•The Future of Vaccine Safety
•Vaccine Shortages
•Preventing Pandemics
•Project Bioshield Act
•National Bio and Agro-Defense Facility
•DNA Vaccination
•Mucosal Delivery
•Intranasal Delivery
•Vaccine Patches
•Vaccine Chips and Microneedles

3. •Innovations in Vaccine Production
•Nanoparticle Systems
•Cloning
Vaccination protects not only individuals, but also entire communities from diseases spread by
person-to-person transmission.For example, vaccination can prevent about 50% of deaths from
pneumococcal disease and 80% of deaths from influenza-related complications in the elderly.
Pharmacoeconomic studies have demonstrated the value of influenza and pneumococcal
vaccines; however, immunization rates for these diseases continue to be low in the elderly
populations. This report includes profiles of the key players in vaccines, including:
•AlphaVax, Inc.
•Bavarian Nordic A/S
•Baxter Healthcare
•Bharat Biotech
•Crucell /Johnson & Johnson
•Emergent biosolutions
•GlaxoSmithKline
•Medimmune
•Merck & Co. Inc
•Novartis
•Sanofi Pasteur
•Pfizer
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Major points covered in Table of Contents of this report include
Table Of Contents
Executive Summary
THE GLOBAL VACCINES INDUSTRY
Scope and Methodology
Overview
Pediatric Preventative Vaccines
THE MARKET
Adult Preventative Vaccines
THE MARKET
TOTAL MARKET
ISSUES AND TRENDS
Introduction to Vaccines
THE IMMUNE RESPONSE

4. MECHANISM OF ACTION
(Table) Impact of Vaccines in the 20th Century Annual Morbidity in the 20th Century vs 2011
A BRIEF HISTORY: THE DEVELOPMENT OF VACCINES
TYPES OF VACCINES
Attenuated (Weakened) Live Viruses
(Table) Vaccine-Preventable Diseases, August 2012
Killed (Inactivated) Viruses
Toxoid Vaccines
Genetically Engineered/Modified Vaccines
VACCINE APPROVAL PROCESS
(Table) VAERS Table of Reportable Events Following Vaccination
Pediatric Preventive Vaccines
INTRODUCTION
(Table) Global Immunization Rates by Vaccine Type 2010
CHILDHOOD IMMUNIZATION IN THE UNITED STATES
(Table) Immunization Profile of the United States: Population by Age Group, Number of Vaccine-
Preventable Diseases Reported by Disease 1990 - 2010
Childhood Immunization Rates
Challenges to the Vaccine Delivery System
The Effect of U.S. Healthcare Reform
Recommended Childhood Immunization Schedule
(Table) U.S. Recommended Immunization Schedule for Children Ages 0 Through 6 Years, 2012
(Table) U.S. Recommended Immunization Schedule for Adolescents Ages 7 to 18 Years, 2012
State Immunization Recommendations
United Nations Initiatives
PEDIATRIC VACCINE PRODUCTS
BCG
Diphtheria, Tetanus, Pertussis, Hepatitis B and Polio
Haemophilus Influenzae Type B
Hepatitis A
Measles, Mumps and Rubella
Meningococcal Disease
Pneumococcal Conjugate
Rotavirus
Varicella
PEDIATRIC VACCINES IN DEVELOPMENT
COST OF VACCINES IN THE UNITED STATES
(Table) Selected Pediatric Vaccines in Development, August 2012
THEWORLD MARKET FOR PEDIATRIC PREVENTIVE VACCINES
Total Market Size and Forecast
(Table) World Market for Pediatric Vaccines by Type (DTaP/DTP, Hep, HiB, MMR, Combinations,

5. Pneumococcal, Polio, Varicella, Others) 2007-2016 Revenues (in millions)
(Table) World Market for Pediatric Vaccines by Region (U.S., North America, South America, EU,
Japan, India, China, Rest of World) 2006-2015 Revenues (in millions)
Hepatitis Vaccine Market
(Table) World Pediatric Hepatitis Vaccine Market 2007-2016
Haemophilus Influenzae Type B Vaccine Market
(Table) World Hib Vaccine Market, 2007-2016
Measles, Mumps and Rubella Vaccines
(Table) World MMR Vaccines Market 2007-2016
Combination Vaccines Market
(Table) World Combination Vaccines Market 2007-2016
Pneumococcal Vaccine
(Table) World Pediatric Pneumococcal Vaccine Market 2007-2016
Poliovirus Vaccine
(Table) World Poliovirus Vaccine Market 2007-2016
Varicella Vaccines
(Table) World Varicella Vaccine Market 2007-2016
Other Vaccines Market
(Table) World Pediatric Other Vaccines Market 2007-2016
Adult Preventive Vaccines
INTRODUCTION
ADULT VACCINE-PREVENTABLE DISEASES: FACTS AND FIGURES
GLOBAL INFLUENZA SURVEILLANCE PROGRAM
U.S. Surveillance
RECOMMENDATIONS FOR ADULT IMMUNIZATIONS
(Table) Universal Adult Immunization Schedule 2012
(Table) Summary of Recommendations for Adult Immunization
ADULT VACCINE PRODUCTS
Cervical Cancer
(Table) Initiatives to Require HPV Vaccination by U.S. State, 2012
Cholera
Diphtheria-Tetanus
Hepatitis
Influenza
(Table) WHO Pandemic Classification Schedule
Japanese Encephalitis
Pneumococcal Disease
Rabies
Shingles
Typhoid Fever
Yellow Fever

6. ADULT VACCINES IN DEVELOPMENT
(Table) Selected Adult Preventive Vaccines in Development, 2012
THEWORLD MARKET FOR ADULT PREVENTIVE VACCINES
Total Market Size and Forecast
(Table) World Market for Adult Preventive Vaccines by Type (Hepatitis, Influenza, Pneumococcal,
Travel/DT/Misc.), 2007-2016 Revenues (in millions)
(Table) World Market for Adult Vaccines by Region (U.S., North America, South America, EU,
Japan, India, China, Rest of World) 2007-2016 Revenues (in millions)
Cervical Cancer Market
(Table) World Cervical CancerVaccine Market 2007-2016
Hepatitis Market
(Table) World Hepatitis Vaccine Market 2007-2016
Influenza Vaccine Market
(Table) World Influenza Vaccine Market 2007-2016
(Table) 2011 Estimated Population by Region and Selected Age Group (in millions)
(Table) World Pneumococcal Vaccine Market 2007-2016
Travel, DT, and Miscellaneous Vaccine Market
(Table) World Travel; Diphtheria-Tetanus; Miscellaneous Vaccines Market 2007-2016
Vaccines Market Summary
TRENDS DRIVING THE VACCINES MARKET
MARKET SIZE AND FORECAST
(Table) The World Vaccines Market by Vaccine Type 2007-2016 Revenues (in millions)
Vaccine Sales by Region
Vaccine Market Competitors
(Table) The World Vaccines Market by Region (U.S., North America, South America, EU, Japan,
India, China, ROW) 2007-2016 Revenues in millions
(Table) Major Manufacturers' Shares of the World Vaccine Market, 2011
Pediatric Vaccines
(Table) Major Manufacturer's Shares of the World Pediatric Vaccine Market 2011
Adult Vaccines
(Table) Major Manufacturer's Shares of the World Adult Vaccine Market 2011
Issues and Trends
VACCINE SAFETY
Refusal to Immunize
Obesity
Post-Licensure Surveillance
The Vaccine Injury Compensation Program
World Health Organization
Other Initiatives
The Future of Vaccine Safety

7. VACCINE SHORTAGES
Preventing Shortages in the Developed Countries
Preventing Shortages in Developing Nations
PREVENTING PANDEMICS
U.S. National Vaccine Plan
VACCINES AND BIOTERRORISM
Overview
Project Bioshield Act
(Table) Selected Companies/Laboratories Developing Biodefense Vaccines
National Bio and Agro-Defense Facility
Vaccine Treatment and Evaluation Units
Anthrax
Smallpox
DNA VACCINATION
INNOVATIONS IN VACCINE DELIVERY SYSTEMS
Mucosal Delivery
Intranasal Delivery
Vaccine Patches
Vaccine Chips and Microneedles
INNOVATIONS IN VACCINE PRODUCTION
Plants
Insects
Nanoparticle Systems
Cloning
Company Profiles
ALPHAVAX, INC.
History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information
BAVARIAN NORDIC A/S
History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information
BAXTER HEALTHCARE
History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information
BHARAT BIOTECH

8. History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information
CRUCELL /JOHNSON &JOHNSON
History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information
EMERGENT BIOSOLUTIONS
History and Lines of Business
Strategic Alliances
Vaccine Products
Financial
GLAXOSMITHKLINE
History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information
MEDIMMUNE
History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information
MERCK&CO. INC
History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information
NOVARTIS
History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information
History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information
SANOFI PASTEUR
History and Lines of Business
Strategic Alliances
Vaccine Products

9. Financial Information
Company Directory
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