Overview of research progress on age-related macular degeneration in 2008.

1. Top Ten AMD Stories of 2008 Rick Trevino, OD Evansville VA Clinic http://richardtrevino.net and early 2009

2. Top Ten AMD Stories 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. Topical Therapy Baseline Characteristics 10. 9.

8. Top Ten AMD Stories 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. Topical Therapy Baseline Characteristics Modifiable Risk Factors

15. Top Ten AMD Stories Topical Therapy Baseline Characteristics Modifiable Risk Factors Cataract and AMD 1. 2. 3. 4. 5. 6. 7. 8. 9. 10.

21. Top Ten AMD Stories Topical Therapy Baseline Characteristics Modifiable Risk Factors Cataract and AMD Photodynamic Therapy 1. 2. 3. 4. 5. 6. 7. 8. 9. 10.

23. Photodynamic Therapy

25. Top Ten AMD Stories 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. Topical Therapy Baseline Characteristics Modifiable Risk Factors Cataract and AMD Photodynamic Therapy Retinal Prostheses

30. Retinal Prostheses Subretinal Implant

31. Retinal Prostheses Subretinal Implant

33. Retinal Prostheses Epiretinal Implant

34. Retinal Prostheses Epiretinal Implant

37. Top Ten AMD Stories 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. Topical Therapy Baseline Characteristics Modifiable Risk Factors Cataract and AMD Photodynamic Therapy Retinal Prostheses Lutein

41. Lutein

42. Top Ten AMD Stories 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. Topical Therapy Baseline Characteristics Modifiable Risk Factors Cataract and AMD Photodynamic Therapy Retinal Prostheses Lutein Anti-VEGF Therapy

48. Top Ten AMD Stories Topical Therapy Baseline Characteristics Modifiable Risk Factors Cataract and AMD Photodynamic Therapy Retinal Prostheses Lutein Anti-VEGF Therapy Genetics 1. 2. 3. 4. 5. 6. 7. 8. 9. 10.

51. Genetics AMD ODDS RATIO (%) CFH ARMS2

53. Genetics - Low risk - Low risk

55. Top Ten AMD Stories 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. Topical Therapy Baseline Characteristics Modifiable Risk Factors Cataract and AMD Photodynamic Therapy Retinal Prostheses Lutein Anti-VEGF Therapy Genetics Fish Oil

57. Pooled odds ratios for AMD, comparing the highest with the lowest dietary intake categories. A: Omega-3 fatty acid intake and late AMD 38% reduction in risk. B: Fish intake and early AMD 24% reduction in risk. If only prospective studies are pooled, there is a 37% reduction in risk. C: Fish intake and late AMD 33% reduction in risk. The diamond’s vertical axis indicates the pooled odds ratios, while its horizontal axis spans the 95% confidence intervals (CIs) from pooled analyses. * Indicates a case-control study; †, cross-sectional study; error bar, 95% CIs; squares, point estimates of each study.

61. Top Ten AMD Stories 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. Topical Therapy Baseline Characteristics Modifiable Risk Factors Cataract and AMD Photodynamic Therapy Retinal Prostheses Lutein Anti-VEGF Therapy Genetics Fish Oil

62. Top Ten AMD Stories Thank You!