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Amelioration of Metabolic Acidosis and Progression of CKD (Journal Club)

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R
Raj Kiran Medapalli
Salud y medicina
1 de 37
Raj Kiran Medapalli, MD, MPH. Nephrology Fellow July 28th, 2010 Mount Sinai School of Medicine Division of Nephrology Journal Club
 
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At 30 months: NaCit vs. No-NaCit: 107.1±48.7 vs 146.9 ±44.6 mg/g Cr; p=0.002
 
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Shah, Hostetter et al. AJKD 2009 Aug; 54(2): 270-277 Low serum bicarbonate levels have been shown to be associated with progression of kidney disease independent of baseline eGFR and other clinical, demographic, and socioeconomic factors.
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Amelioration of Metabolic Acidosis and Progression of CKD (Journal Club)

  • 1. Raj Kiran Medapalli, MD, MPH. Nephrology Fellow July 28th, 2010 Mount Sinai School of Medicine Division of Nephrology Journal Club
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  • 28. At 30 months: NaCit vs. No-NaCit: 107.1±48.7 vs 146.9 ±44.6 mg/g Cr; p=0.002
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  • 33. Shah, Hostetter et al. AJKD 2009 Aug; 54(2): 270-277 Low serum bicarbonate levels have been shown to be associated with progression of kidney disease independent of baseline eGFR and other clinical, demographic, and socioeconomic factors.
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Notas del editor

  1. Normally, after a dietary acid load there is distal nephron acidification (increased H+ secretion & decreased HCO3 secretion in DCT, resulting in decreased HCO3 delivery to terminal distal nephron, -> increased titration of non-HCO3 buffers).