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Embase introduction - 13 July 2014
- 1. Embase® is a registered trademark of Elsevier BV. Welcome to our Embase introduction webinar! Your presenter: Sherry Winter
- 2. DISCOVERY PRE-CLINICAL CLINICAL POST-LAUNCH A SUITE OF INTEROPERABLE, DOMAIN-SPECIFIC, DECISION SUPPORT TOOLS EMBASE IS PART OF OUR LIFE SCIENCE SOLUTIONS Characterize targets & analyze disease pathways Characterize & discover molecules Identify & confirm lead compounds Translate preclinical data in humans (Translational) Monitor drug adverse events & real-world evidence data in literature Integrate the world of data & solutions Drug Candidate Selection Go-No Go Decision Preclinical Data Validation Managing risk Text Mining & Data Integration 2
- 3. 3 Webinar control panel: • ‘Ask a question’ for questions and comments • Option for full screen view • Q&A at the end NEED TO KNOW
- 4. 4 WHY DO PEOPLE USE EMBASE? Pharma Devices Academia Track literature Aggregate evidence Postmarket Surveil. (PV) Compet. Intel. Clinical Evaluation Systematic Review
- 5. 5 DELIVERING VALUE TO YOUR BIOMEDICAL SEARCHES Conference proceedings Very powerful Search Environment ...by including literature and information resources in a timely manner ...by reading full-text to identify drugs, diseases, adverse affects, clinical trials, drug trade names etc. ...by enabling advanced search filters to drill down a comprehensive search to a relevant and manageable record set Scientific Journals In Press (unpublished) ...by allowing users to automate searching and result management E-mail Alerting API Interoperability Deep indexing using own taxonomy (EMTREE) We make sure you don’t miss any biomedical literature The only close alternative is reading all the articles Good precision and recall balance Automation and documentation
- 6. 6 WE MAKE SURE YOU DON’T MISS ANY BIOMEDICAL LITERATURE
- 7. 7 CONTENT OVERVIEW Emtree: Biomedical thesaurus, over 69k terms Embase: Fully indexed: Over 8,400 journals (including MEDLINE), 1950- MEDLINE: 2,500 journals: MeSH terms are mapped to Embase indexing, 1950- (including MEDLINE Classic) Embase Classic: Digitally scanned and re-indexed, 1947-1973 AIP and In Process: Indexing added, from 2009 Conference Abstracts: Indexing added, from 2009 1947 1950 1974 2009 Including >6M not found in MEDLINE
- 8. 8 BIOMEDICAL SCOPE AND COVERAGE EXTENSIVE COVERAGE OF PEER-REVIEWED BIOMEDICAL LITERATURE Pharmacology & Toxicology 12% General Clinical Medicine 11% Genetics, Biochemistry & Molecular Biology 10% Neurology & Behavioral Medicine 8% Microbiology & Infectious Disease 7% Cardiology & Hematology 6% Psychiatry & Mental Health 6% Oncology 5% Healthcare Policy & Management 4% Allergy & Immunology 4% Pediatrics 4% Endocrinology & Metabolism 3% Obstetrics & Gynecology 3% Biomedical Engineering & Medical Devices 3% Anesthesiology & Intensive Care 3% Gastroenterology 2% Respiratory Medicine 2% Nephrology & Urology 2% Dermatology 2% Other topics 28% Including public health, basic biomedical science and topics included from MEDLINE
- 9. 9 CONFERENCE ABSTRACTS Coverage began in 2009. Click here for an up to date list (http://www.elsevier.com/online-tools/embase/about )
- 10. 10 DEEP INDEXING
- 11. 11 EMBASE INDEXING COMPARED TO MEDLINE
- 13. 13 START SEARCHING… Find the best terms for your search and include synonyms automatically with autocomplete in Quick Search
- 14. 14 EASY-TO-USE FILTERS FOCUS SEARCH TO RELEVANT AND MANAGEABLE PROPORTIONS Click on Drug Filter for example, to see which drugs are referenced in your search.
- 15. 15 EASY TO MANAGE RESULTS WITH EMAIL ALERTS, EXPORTING AND ADVANCE SEARCHING Register to set up email alerts to automatically receive new search results (frequencies range from daily to yearly) Copy the search query to Advanced Search to apply additional limits Export, print or share results – choose from formats including RIS, text or CSV
- 16. 16 SEARCHING IN EMBASE FOR RESULTS
- 17. 17 a. Building systematic searches b. Pinpointing specific drug and disease-related information c. Saving searches and setting up alerts POLL: WHAT ARE YOU MOST INTERESTED IN?
- 18. 18 Meet Carol, a clinical liaison librarian, in the Center for Evidence-Based Research. Carol is working on a systematic review for publication and she needs to adhere to specific guidelines to ensure she has conducted a through search of the literature. Let’s dive into EMBASE and show Carol how she may efficiently search all relevant biomedical literature, while being confident that she is not missing anything.
- 19. 19 Meet Carol, an information specialist supporting pharmacovigilence. Carol needs to ensure that she is setting up searches across all relevant sources, to track all adverse events for 3 of their products on the market. There is so much info to track and she has to be confident when reporting that she has not missed anything. Let’s dive in to EMBASE and see how Carol may quickly review all side effects for her drugs, while being confident that she is not missing anything
- 20. 20 ARE YOU MISSING SOMETHING? 2 thesaurus assisted searches but different results? Embase has unique journal content and conference abstracts…
- 21. 21 ARE YOU MISSING SOMETHING? We were looking for digoxin AND ‘antibiotics’ but MEDLINE does NOT index digoxin in this article.
- 22. 22 • Use single quotes to capture a phrase ‘diabetes mellitus’ for example (not with Autocomplete in Quick Search) • Break up your search into individual searches, such as a drug search (in Drug Search form) and a disease search (in Disease Search form) and combine your results in Session Results • Run your cursor over your search to Edit or copy to a Search Form for guided editing • Truncation and operators, AND, OR, NOT, NEXT, NEAR BUILDING AND COMBINING SEARCHES Refer to http://info.embase.com/helpfiles for more guidance and links to materials such as the Quick User Guide.
- 23. 23 • Quick and Advanced Limits on Advanced, Drug and Disease Search forms • Major Focus on all advanced forms – major drugs and diseases retrieved • Field limits under Advanced Search box to search in specific fields such as article title, abstract, conference name, drug name etc. • Drug and Disease Subheadings to limit to specific concepts such as Adverse Drug Reaction, Drug Comparison and Side Effect. • Filters on Session Results page for specific diseases or study types for example REFINING YOUR SEARCH Check out our training videos at www.trainingdesk.elsevier.com/embase for more guidance
- 24. 24
- 25. 25 • Q&A will be sent to you by email and for more information and questions please contact your regional office • Our next Embase webinar is on Sept 24 and is focused on literature searching for Medical Devices. • From July 31, please go to Help for all Embase training materials and a webinar overview THANK YOU SEE YOU NEXT TIME! Please fill out the survey that appears on your screen after leaving the webinar.
Notas del editor
- First, I’d like to introduce you to Embase and how it fits in with our Elsevier Life Science Solutions. It’s part of a portfolio of products that work together across your research workflow, whether you work in the field of biology, chemistry, pharmacokinetics, pharmacovigilance or many others. For example, across the drug development workflow, Pathway studio…. And just before we start our Embase introduction…
- …A few need to knows. During the session you may send us your questions by using the ‘Ask a Question’ feature on your webinar control panel. We will have 10-15 minutes for questions at the end and for those questions we do not answer in the webinar, they will be included in a complete Q&A sent to all attendees by email.
- You are probably familiar with Medline, which can be searched using PubMed – but did you know that Embase includes all Medline data, plus content that is unique to Embase? Embase includes more than 8400 journals (this includes Medline journals). 2700 of the journals in Embase are unique to Embase, x # of journals can be found in both Medline and Embase, but are indexed using the Embase thesaurus, Emtree, and 2500 journals in Embase are unique to Medline. We include them in Embase and map the MeSh terms (the Medline thesaurus) to Emtree terms so that these journals are fully searchable using Embase. Embase also includes Embase classic and articles in press and in publication. Importantly, conference abstracts are included in Embase – this content is unique to us and e now cover over 4,500 conferences with over 1.4M conference abstracts.. All in all, more than 6M records can be found in Embase that aren’t found in Medline.
- Embase includes a focus on biomedical content and drug, disease and medical device indexing. For example, pharmacology and toxicology journals make up the largest segment of journals we cover, followed closely by general clinical medicine and genetics journals. This focus on biomedical content and drug, device and disease indexing makes Embase a key resource for pharmacovigilance, medical device development and post-market surveillance, and for doing systematic reviews that support of Evidence based medicine decisions.
- We have several different types of content or study types - and searching for specific content is possible using the field limits. For example, you can use field limits to search for for conference name, conference date and conference location. You may also select conferences from the Publication Type limit or AiP. You will also notice AiP/In Process in Quick limits for even easier accessibility.
- 10
- This is a record/article in EMBASE, showing the index terms. If you type in any of these terms or their synonyms or exploded terms (this is more specific terms, such as non-insulin dependent diabetes is an exploded term for diabetes), thanks to EMBASE indexing and the search form set up, you will easily find this article. EMBASE currently indexes over 69K terms using a controlled vocabulary, or thesaurus, called EMTREE. Over 31K are drug terms and we now have 3K medical device related terms. In order to stay relevant, we update EMTREE 3 times a year. EMBASE and MEDLINE have different indexing policies. And here you can see the MEDLINE index for the same record. Given the EMBASE focus on drugs, you can see that the EMBASE index is significantly more detailed, especially for drug-related indexing. This is an important difference between EMBASE and MEDLINE and we will look at this again later.
- Now that you have access to the biomedical literature and a huge selection of relevant index terms, how DO you find your answers?
- Start with Quick Search, which allows fast and easy access to the best terms for your search. The autocomplete function suggests the best matches to the term you’re typing to one found in Emtree. You can see how many records have been indexed with a particular term.
- From the session results page, you can use the filters on the left-hand side of the page to further refine your results. For example, here you can see the drug filter and see which drugs are referenced in our result set. This is particularly useful, as you can filter the results by a specific drug, or you can also export up to 2000 items in a filter set to do advanced analysis on the type of drugs that are reported in your result set.
- It’s also easy to manage your search results by using a number of functions, such as export, copy to advanced search or register in Embase so you can save your searches or set up email alerts. Registering also means you receive all up to date information such as upcoming webinars.
- POLL If majority choose first option, then choose the workflow on slide 16. If majority choose second option, the choose the workflow on slide 17 If majority choose third option (which they never do but may be a first time), then choose workflow on slide 17, shorten and move more quickly to email alerts.
- ACADEMIC SEARCH in EMBASE: Carol is working on a systematic review about the risks of administering digoxin and antibiotics to a patient with congestive heart failure. We are first going to search for digoxin and antibiotics. Search for digoxin AND antibiotics in Quick Search (show autocomplete and how simple your search can be in EMBASE). Point out that this is searching EMBASE and MEDLINE content, including conference abstracts, which you will show later in the session results page (refer to the new filter and publication type filter) Compare search forms by searching for Digoxin AND antibiotics in Advanced (show field limits such as title, abstract, conference name and manufacturer and device trade names and manufacturers). Complete the comparison by searching for digoxin AND antibiotics in Drug and use the subheading drug therapy for example. Also, run your search with exploded OFF to show the difference in number of results and the impact of indexing on your search, compared to using a non-controlled vocabulary search. This is a good way to expand your search, especially for a term such as antibiotics. And then with major focus ON, this is a good way to refine your search. From the session results page, you now have many options for further refining your search, including the brand NEW MEDLINE/EMBASE records filter. Next, we want to find results for our disease of interest. Start to type ‘congestive heart failure’ in the search box at the top of session results with autocomplete. Also open EMTREE and show how you can more deeply investigate a therapeutic area of interest or family of drugs in EMTREE. Type in ‘congestive heart failure’ and click on ‘Take to disease search’. Choose ‘drug therapy’ subheading. Combine one of your digoxin and antibiotic searches with your disease search and observe the results. EMBASE allows you to test the relevancy and comprehensiveness of your search by narrowing and broadening your search. Point out saving searches and email alerts. Go back to slide 18.
- CORPORATE SEARCH in EMBASE: Let’s take a look at sitagliptin, a drug used to treat non-insulin dependent diabetes as an example and search for adverse events. Search for sitagliptin in Quick Search (show autocomplete and how simple your search can be in EMBASE). Type in Diabetes to show that you can search for more than one term using autocomplete. Point out that this is searching EMBASE and MEDLINE content, including conference abstracts, which you will show later in the session results page (referring to the NEW filter and publication type filter) From the session results page, you now have many options for further refining your search, including the brand NEW MEDLINE/EMBASE records filter and publication type, such as conference abstracts. Compare search forms by searching for sitagliptin in Advanced (show field limits such as title, abstract, conference name and manufacturer and drug and device trade names and manufacturers). Complete the comparison by searching for sitagliptin in Drug and use the subheading ‘Adverse Drug Reaction’. It is possible to combine our drug search with a therapeutic area of interest. Start to type ‘diabetes’ in the search box at the top of session results with autocomplete. Also open EMTREE and show how you can more deeply investigate a therapeutic area of interest or family of drugs in EMTREE. Type in ‘diabetes’ and click on ‘Take to disease search’. Choose ‘drug therapy’ subheading. Also, run your search with exploded OFF to show the difference in number of results and the impact of indexing on your search, compared to using a non-controlled vocabulary search. This is a good way to expand your search, especially for a term such as diabetes. And then with major focus ON, this is a good way to refine your search. Combine sitagliptin with subheading search with your disease search and observe the results. EMBASE allows you to test the relevancy and comprehensiveness of your search by narrowing and broadening your search. Open up index terms to show the drug and disease index terms and subheadings. Log in and set up this search as an email alert. Show the email alert page. Go back to slide 18.
- Now that we’ve seen how Embase works, let’s compare Embase with Pubmed - We are often asked about the differences with Pubmed/MEDLINE and I’ve already shown you some differences in content and indexing. Here is an example of a search for digoxin and antibiotics. This clinical librarian would like to know if there are any risks involved in administering both drugs to a patient. Searching in Pubmed, we found 140 results compared to 6,855 in Embase. We know there is unique content in Embase - for example, over 2,600 unique journal titles (6M records) and conference abstracts - but there is also a difference in indexing focus, Embase indexes more drugs, more deeply – The question is, what effect does this have on your results?
- In this case, this specific article, which we know contains important information on the administration of digoxin and antibiotics to a ‘congestive heart failure’ patient, although present in MEDLINE is not indexed with digoxin and therefore our search for digoxin and antibacterial agents did not find this article in MEDLINE. This article is found when you search for digoxin and antibiotics in Embase.
- So, just to recap, here are some tips for building and combining effective searches
- And here’s how you can further refine your searches