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SSDN SACHIN LPU GUIDE MR. NARENDRA PANDEY
1. PREPARATION AND EVALUATION OF MOUTH DISSOLVING TABLET Presented By: Under the guidance of: Sachin Mr. NarendraPandey
2. Contents Literature Review Introduction Promising drug candidates for MDT Popular Disintegrants used in MDT Techniques for MDT formulation Marketed Products of MDT Evaluation Future Planning 2
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4. Shirsand S B, Suresh S, Para M S, Swamy P V, Kumar N D, Plantagoovata mucilage in the design of fast disintegrating tablets. Indian J. Pharm. Sci. 2009;41-46.
5. Gattani S. G, Shiyani B.G, KakadeK.N,Patil A.B, Surana S.J. Formulation and evaluation of mouth dissolving tablet of ondansetron hydrochloride by using superdisintegrants. Indian drugs. 2009; 46(1): 44-50.
6. Shoukri A R, Ahmed S I, Shamma N R. In vitro and in vivo evaluation of nimesulidelyohilized orally disintegrating tablets.Eur. J. Pharm. biopharm. 2009; 30: 1-10.
7. Goswami J P, Sharma S, Gupta G D. An effervescent and reproducible method for prepration of fast disintegrating tablets. Pharma Buzz. 2009; 4(3): 46-52.3
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9. Shukla D, Chakraborty S, Singh S, Mishra B. Mouth dissolving tablets: An overview of Formuation technology. ScientiaPharmaceutica. 2009; 77: 309-326.
10. Fini A, Bergamante V, Ronchi C, Moraes F A C. Fast Dispersible/slow releasing ibuprofen tablets. Eur. J. Pharm. Biopharm. 2008; 69: 335-341.
11. Shah P P, Rajashree C M. Formulation and evaluation of primaquine phosphate taste- masked rapidly disintegrating tablet. J. Pharm. Pharmcol. 2008; 60: 1279-1285.
12. Rashid I, Remawi A M, Eftaiha A A,BadwanA.Chitin –Silicon Dioxide coprecipitate as a novel superdisintegrant. Indian J. Pharm. Sci. 2008; 97(11): 4955-4969.
13. Patel D M, Patel M M..Optimization of etorocoxib tablets prepared by sublimation technique. Indian J. Pharm. Sci. 2008; 70(1): 71-76.
14. Chaudhri P.D, Chaudhari S.P, Lanke S.D, Patel N. Formulation and in vitro evaluation of taste masked orodispersible dosage form of levocetirizinedihydrochloride. Indian J. Pharm. Edu. Res. 2007; 41(4): 319-327.4
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16. Qalaji R M M, Simons R E F, Simons J K. Fast-disintegrating sublingual epinephrine tablets: Effect of tablet dimension on tablet characteristics. Drug Dev. Ind. Pharm. 2007; 33: 523-530.
17. Shishu, AshimaB,Singh T. Preparation of tablets Rapidly disintegrates in the saliva containing bitter taste masked granules by compression method. Indian J. Pharm. Sci. 2007; 69(1):80-84.
18. Ciper M, Bodmeier R. Modified conventional hard gelatin capsules as fast disintegrating dosage form in the oral cavity. Eur. J. Pharm. biopharm. 2006; 62: 178-184.
19. Mizumoto T, Masuda Y, Yamamoto T, Yonemochi E, Terada K.formulation design of a novel fast-disintegrating tablet. Int. J. Pharm. 2005; 306: 83-90.
20. Valleri M, Mura P, Cirri M, Balllerini R. Development and evaluation of glyburide fast dissolving tablets using solid dispersion technique.Drug Dev. Ind. Pharm. 2004; 30(5): 525-534.5
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22. USP and EP used the term ODT for the tablets that disperses readily and within 3 minutes in mouth before swallowing.
23. US-FDA defined ODT as “A solid dosage form containing medicinal substances or active ingredient which disintegrates rapidly usually with in a matter of seconds when placed on the tongue.”Shukla et al., Mouth Dissolving Tablet: An overview of Evaluation Techniques. Sci. Pharm. 2009; 77: 309-326. 6
28. Benefit of both liquid and solid dosage formGopala et al., An Effective and Reproducible Method For Preparation Of Fast disintegrating tablet. Pharma Buzz. 2008; 3(9): 38-40 7
29. Promising drug candidates for MDT . 8 Sharma et. al. Mouth dissolving tablet : A Review. Pharma Buzz. 2009; 4(1): 30-41
34. Mechanism of action of superdisintegrants 13 Sharma et al., Mouth dissolving tablet: A review.Pharma Buzz.2009; 4(01): 30-41.
35. Techniques for MDT formulation Lyophilisation Moulding Direct compression Cotton candy process Spray drying Sublimation Mass extrusion Nanonization Fast dissolving films 14 Shukla et al., Mouth Dissolving Tablet: An overview of formulation technology. Sci. Pharm. 2009; 77: 309-326.
36. Sublimation technique for prepration of mdt 15 Sharma et al., Mouth dissolving tablet: A review.Pharma Buzz.2009; 4(01): 30-41.
37. 16 List of Patented Technology Based Branded Products Shukla et al., Mouth Dissolving Tablet: An overview of formulation technology. Sci. Pharm. 2009; 77: 309-326.
50. Dissolution test Terada et. al. Evaluation of rapidly disintegrating tablets containing glycine and carboxymethylcellulose. Int. J. Pharm., 2006; 310: 101-109. 20
51. in vitro dispersion test 21 Kumar S R, Lakshmi S V P. Reprimelts: A novel approach in drug delivery systems.Pharma buzz. 2009; 4(7): 72-76
52. 22 Electroforce Disintegration Test Apparatus Shukla et. al ,Mouth Dissolving Tablet: An overview Of Evaluation Techniques. Sci. Pharm. 2009; 77: 309-326.
53. Disintegration test with rotary shaft method 23 Shukla et. al ,Mouth Dissolving Tablet: An overview Of Evaluation Techniques. Sci. Pharm. 2009; 77: 309-326.
54. Modified Dissolution Test Apparatus For Disintegration Test Shukla et al., Mouth Dissolving Tablet: An overview Of Evaluation Techniques. Sci. Pharm. 2009; 77: 309-326. 24