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Nucleic acid play an important role in transmission of hereditary characteristics and biosynthesis of proteins. DNA and RNA * CONTENTS Introduction to Nucleic acids History of Nucleic acids Structure of Nucleic acids Description of Nucleic acids Chemical structure of DNA and RNA Classifications of Bases Sites of Nucleic acids Names of Nucleosides and Nucleotides Conclusion References * Structure of Nucleic acids NA structure is often divided into four different levels: Primary structure Secondary structure Tertiary structure Quaternary structure * Primary structure: consists of a linear sequence of nucleotides that are linked together by phosphodiester bond. Nucleotides consists of 3 components: Nitrogenous base 5-carbon sugar One or more phosphate groups * Secondary structure This is the set of interactions between bases. In DNA double helix, the two strands of DNA are held together by hydrogen bonds. The nucleotides on one strand base pairs with the nucleotide on the other strand. The secondary structure is responsible for the shape that the nucleic acid assumes. * Tertiary structure This is the locations of atoms in three-dimensional space, taking into consideration geometrical and steric constraits. A higher order than the secondary structure in which large scale folding in a linear polymer occurs and the entire chain is folded into a specific 3-dimensional shape. * Quaternary structure This is similar to that of protein quaternary structure. Although some of the concepts are not exactly the same. QS refers to a higher level of organization of nucleic acids moreover, it refers to the interactions of the nucleic acids with other molecules. * NNuucclleeiicc AAcciiddss Nucleic acids are molecules that store information for cellular growth and reproduction * There are two types of nucleic acids: - deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) * These are polymers consisting of long chains of monomers called nucleotides A nucleotide consists of a nitrogenous base, pentose sugar and a phosphate group. * DNA and RNA are nucleic acids, long, thread-like polymers made up of a linear array of monomers called nucleotides All nucleotides contain three components: 1. A nitrogen heterocyclic base 2. A pentose sugar 3. A phosphate residue * Ribonucleotides have a 2’-OH Deoxyribonucleotides have a 2’-H * Bases are classified as Pyrimidines or Purines * Nucleus Cytoplasm replication DNA transcription RNA (mRNA) translation Proteins * reverse transcription messenger RNA (mRNA) transfer RNA (tRNA) ribosomal RNA (rRNA) * Names of Nucleosides and Nucleotides * X-ray diffraction patterns produced by DNA fibers Rosalind Franklin and Maurice Wilkins * 1962 Nobel Prize in Physiology or Medicine for their discoveries concerning the molecular structure of nucleic acids and its significance for information transfer in living material" James Watson Francis Crick Maurice Wilkins
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Nucleic acid play an important role in transmission of hereditary characteristics and biosynthesis of proteins. DNA and RNA * CONTENTS Introduction to Nucleic acids History of Nucleic acids Structure of Nucleic acids Description of Nucleic acids Chemical structure of DNA and RNA Classifications of Bases Sites of Nucleic acids Names of Nucleosides and Nucleotides Conclusion References * Structure of Nucleic acids NA structure is often divided into four different levels: Primary structure Secondary structure Tertiary structure Quaternary structure * Primary structure: consists of a linear sequence of nucleotides that are linked together by phosphodiester bond. Nucleotides consists of 3 components: Nitrogenous base 5-carbon sugar One or more phosphate groups * Secondary structure This is the set of interactions between bases. In DNA double helix, the two strands of DNA are held together by hydrogen bonds. The nucleotides on one strand base pairs with the nucleotide on the other strand. The secondary structure is responsible for the shape that the nucleic acid assumes. * Tertiary structure This is the locations of atoms in three-dimensional space, taking into consideration geometrical and steric constraits. A higher order than the secondary structure in which large scale folding in a linear polymer occurs and the entire chain is folded into a specific 3-dimensional shape. * Quaternary structure This is similar to that of protein quaternary structure. Although some of the concepts are not exactly the same. QS refers to a higher level of organization of nucleic acids moreover, it refers to the interactions of the nucleic acids with other molecules. * NNuucclleeiicc AAcciiddss Nucleic acids are molecules that store information for cellular growth and reproduction * There are two types of nucleic acids: - deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) * These are polymers consisting of long chains of monomers called nucleotides A nucleotide consists of a nitrogenous base, pentose sugar and a phosphate group. * DNA and RNA are nucleic acids, long, thread-like polymers made up of a linear array of monomers called nucleotides All nucleotides contain three components: 1. A nitrogen heterocyclic base 2. A pentose sugar 3. A phosphate residue * Ribonucleotides have a 2’-OH Deoxyribonucleotides have a 2’-H * Bases are classified as Pyrimidines or Purines * Nucleus Cytoplasm replication DNA transcription RNA (mRNA) translation Proteins * reverse transcription messenger RNA (mRNA) transfer RNA (tRNA) ribosomal RNA (rRNA) * Names of Nucleosides and Nucleotides * X-ray diffraction patterns produced by DNA fibers Rosalind Franklin and Maurice Wilkins * 1962 Nobel Prize in Physiology or Medicine for their discoveries concerning the molecular structure of nucleic acids and its significance for information transfer in living material" James Watson Francis Crick Maurice Wilkins
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Nucleic Acids
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