1. MOLLECULAR SWITCHES: FROM
THE RNA WORLD TO THE
MODERN PROTEIN WORLD AND
CHEMISTS DEVELOP MORE
EFFICIENT PROTEIN LABELING
Sara Guzmán Restrepo
Medicine Student, 3rd Semestrer
Teacher: Lina María Martinez
Molecular Biology

4. INTRODUCTION
• is important to know the new
advances in science to diagnose,
prevent or cure a disease
• The study’s function of new
molecules, may change previous
theories

5. MOLLECULAR SWITCHES:
FROM THE RNA WORLD TO
THE MODERN PROTEIN
WORLD.

6. MOLLECULAR SWITCHES: FROM THE RNA
WORLD TO THE MODERN PROTEIN WORLD.
 They are described as
molecular switches that
oscillate between 'on' and
'off', regulated by effectors.

7. MOLLECULAR SWITCHES: FROM THE RNA
WORLD TO THE MODERN PROTEIN WORLD.
 The G protein FlhF, together
with a signal sequence
binding protein (SRP54) and
its receptor (FtsY),
constitutes the ancient family
of SRP-GTPases

8. MOLLECULAR SWITCHES: FROM THE RNA
WORLD TO THE MODERN PROTEIN WORLD.
 it was recently demonstrated
that the protein SRP54 and
the receptor FtsY interact with
the SRP RNA in a way
reminiscent of FlhF and its
newly discovered effector.

9. COMMENT
Is important to understand the function
and structure of the effectors because
from these you can create an inhibitor
for the same molecule, if a disease
requires.

10. Chemists Develop More
EfficIent Protein labeling
beling

11. Chemists Develop More EfficIent Protein labeling beling
 Protein labeling is used by
researchers in a variety of
fields to help them
understand how these
important molecules affect
the normal functioning of
cells

12. Chemists Develop More EfficIent Protein labeling beling
 Deiters and Chin developed a special 21st
amino acid that they added to cells that were
specially engineered to incorporate this amino
acid into the protein they wanted to study
 This 21st amino acid has a “chemical handle”
that only reacts with a specifically designed
fluorophore, but not any cellular components

13. Chemists Develop More EfficIent Protein labeling beling
 they found that their approach
gave them a higher yield of
labeled proteins and that the
binding reaction was 50 times
faster than with current
methods

14. COMMENT
this discovery is really important to
understand the movement and the
role of one of the most important
molecules in the body, through a
signaling method much more effective

15. MEDICAL UTILITY

16. MEDICAL UTILITY
 Everything that is
discovered about the man
helps us understand how
to make it through difficult
processes, makes this
great body?

17. MEDICAL UTILITY
 The importance of knowing
these molecules has led to a
detailed study, so that the
proteins have provided much
information about the
discovery of the treatment
and cure of many diseases

18. MEDICAL UTILITY
 modern medicine and
science has limits, every day
we discover a new disease,
the important thing is that
with the help of these studies
may be possible to
understand and treat

19. BIBLIOGRAPHY
• “Cellular Switches: From the RNA World to the 'Modern'
Protein World”, ScienceDaily journal, internet
edition,February. 9, 2012
http://www.sciencedaily.com/releases/2012/02/120209101607.
htm
• “Chemists Develop More Efficient Protein Labeling”
ScienceDaily journal, internet edition,Feruary. 5, 2012,
http://www.sciencedaily.com/releases/2012/02/1202051637
16.htm