Bacterial & Viral Reproduction

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“The single biggest threat to man’s continued dominance on the planet is the virus”. Joshua Lederberg, Ph.D., Nobel laureate, Film introduction: Outbreak (1995). What is Virus? The human race was at its knees. You know how the Covid-19 virus pandemic impacted millions of lives worldwide. Viruses are the smallest and simplest infectious agents that can replicate only inside the living cells of an organism. As viruses lack their own structure, they are unable to replicate on their own and must infect a host cell to reproduce. When a virus infects a host cell, it inserts its genetic material in the host cell’s genes in order to create copies of itself. As the virus multiplies, the infected host cell bursts to release new viruses into the surrounding environment. These new viruses can then go on to infect other cells and even infect other organisms, leading to the spread of the virus and infection. Viruses can infect all life forms, from humans, animals, and plants to micro-organisms including bacteria and fungi. Most viral infections if occur in healthy individuals are usually asymptomatic or with mild symptoms. Why do viruses mutate so frequently? Like all other living forms, viruses also go through mutations throughout their lifespan. However, their genetic structure especially of RNA viruses lacks proofreading skills, which makes them undergo random “copying errors” (i.e., genetic mutations) during replication. This also makes them prone to high mutation rates. That’s why most pandemic infections are usually viral in origin. The more it circulates, the more it can change. However, the more virulent virus may be less transmissible, because it reduces the chances of transmission by killing the host. Viruses usually mutate in immunocompromised individuals. If viruses don’t get host cells, their population in the environment may decrease or remain stable. Viruses may swap genetic material with the host to make a new “mixed” virus with unique properties. This may lead to horizontal gene transfer from a host to a virus or from a virus to a host, which plays an important role in the mutation and evolution of all organisms. All living forms including humans, plants, and animals are evolved from/by micro-organisms; however, micro-organisms are evolved to keep control of macroorganisms. Why viruses are more dangerous? Viruses are more unstable like an ion because they lack their own structure to reproduce. They must need a host to grow and replicate. Viruses enter the host cell by camouflaging and tricking it. They first incorporate their genome with the host genome and then multiply by “commandeering” and “hijacking” the host cell to produce more viruses. The infected cell doesn’t know that the commandeering is by the virus, and thus unknowingly becomes a virus factory. New viruses then burst out of a host cell and enter into new cells to repeat the process. This makes a host helpless, functionless, and even defenseless. You felt sick because your body is

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