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Probability & Genetics

AP Biology

2006-2007
Genetics & Probability
 Mendel’s laws:
segregation
 independent assortment


reflect same laws of
probability that apply to
tossing coins or rolling dice

AP Biology
Probability & genetics
 Calculating probability of
making a specific gamete
is just like calculating the
probability in flipping a
coin
probability of tossing
heads?
 probability making a B
gamete?

B
100%

BB
B



AP Biology

B
50%

Bb
b
Probability & genetics
 Outcome of 1 toss has no
impact on the outcome of the
next toss
probability of tossing heads
each time? 50%
 probability making a B gamete
each time? 50%


B

Bb
b
AP Biology
Calculating probability
Pp x Pp

P

p

egg

offspring

P

male / sperm

sperm

P

PP

P

p

p

P

1/2 x 1/2

female / eggs

1/2 x 1/2

P

PP

Pp

p

Pp

pp

AP Biology

1/2 x 1/2

p

p

1/2 x 1/2

=
=
=

=

1/4

Pp

1/4
+
1/4
1/2

pp

1/4
Rule of multiplication
 Chance that 2 or more independent
events will occur together


probability that 2 coins tossed at the
same time will land heads up

1/2 x 1/2 = 1/4


probability of Pp x Pp → pp

1/2 x 1/2 = 1/4
AP Biology

P
Pp
p
Calculating probability in crosses
Use rule of multiplication to predict crosses

YyRr x YyRr

x

Yy

Yy

Rr

yyrr

x

?%
1/16
yy
AP Biology

rr
1/4

x

1/4

Rr
Apply the Rule of Multiplication
AABbccDdEEFf

x

AaBbccDdeeFf

AabbccDdEeFF

Got it?
Try this!

AP Biology

AA x Aa → Aa
Bb x Bb → bb
cc x cc → cc
Dd x Dd → Dd
EE x ee → Ee
Ff x Ff → FF

1/2
1/4
1
1/2
1
1/4

1/64
Rule of addition
 Chance that an event can occur
2 or more different ways
 sum of the separate probabilities
 probability of Bb x Bb → Bb
sperm

egg

offspring

B

b

Bb

1/2 x 1/2 =

b

B

1/2 x 1/2 =
AP Biology

1/4

Bb

1/4

1/4
+ 1/4
1/2
Chi-square test
 Test to see if your data supports


your hypothesis
Compare “observed” vs. “expected” data
is variance from expected due to
“random chance”?
 or is there another factor influencing data?


 null hypothesis
 degrees of freedom
 statistical significance

AP Biology
AP Biology
Any Questions??

AP Biology

2006-2007

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52 ch13probability2007

  • 1. Probability & Genetics AP Biology 2006-2007
  • 2. Genetics & Probability  Mendel’s laws: segregation  independent assortment  reflect same laws of probability that apply to tossing coins or rolling dice AP Biology
  • 3. Probability & genetics  Calculating probability of making a specific gamete is just like calculating the probability in flipping a coin probability of tossing heads?  probability making a B gamete? B 100% BB B  AP Biology B 50% Bb b
  • 4. Probability & genetics  Outcome of 1 toss has no impact on the outcome of the next toss probability of tossing heads each time? 50%  probability making a B gamete each time? 50%  B Bb b AP Biology
  • 5. Calculating probability Pp x Pp P p egg offspring P male / sperm sperm P PP P p p P 1/2 x 1/2 female / eggs 1/2 x 1/2 P PP Pp p Pp pp AP Biology 1/2 x 1/2 p p 1/2 x 1/2 = = = = 1/4 Pp 1/4 + 1/4 1/2 pp 1/4
  • 6. Rule of multiplication  Chance that 2 or more independent events will occur together  probability that 2 coins tossed at the same time will land heads up 1/2 x 1/2 = 1/4  probability of Pp x Pp → pp 1/2 x 1/2 = 1/4 AP Biology P Pp p
  • 7. Calculating probability in crosses Use rule of multiplication to predict crosses YyRr x YyRr x Yy Yy Rr yyrr x ?% 1/16 yy AP Biology rr 1/4 x 1/4 Rr
  • 8. Apply the Rule of Multiplication AABbccDdEEFf x AaBbccDdeeFf AabbccDdEeFF Got it? Try this! AP Biology AA x Aa → Aa Bb x Bb → bb cc x cc → cc Dd x Dd → Dd EE x ee → Ee Ff x Ff → FF 1/2 1/4 1 1/2 1 1/4 1/64
  • 9. Rule of addition  Chance that an event can occur 2 or more different ways  sum of the separate probabilities  probability of Bb x Bb → Bb sperm egg offspring B b Bb 1/2 x 1/2 = b B 1/2 x 1/2 = AP Biology 1/4 Bb 1/4 1/4 + 1/4 1/2
  • 10. Chi-square test  Test to see if your data supports  your hypothesis Compare “observed” vs. “expected” data is variance from expected due to “random chance”?  or is there another factor influencing data?   null hypothesis  degrees of freedom  statistical significance AP Biology