This presentation on Internal Parasite Control in Sheep was given at the Indianhead Sheep Breeders Association 17th Annual Shepherd's Clinic and Trade Show on February 12, 2011.
This presentation on Internal Parasite Control in Sheep was given at the Indianhead Sheep Breeders Association 17th Annual Shepherd's Clinic and Trade Show on February 12, 2011.
Paratuberculosis is a contagious, chronic and sometimes fatal infection that primarily affects the small intestine of ruminants.
It is caused by the bacterium Mycobacterium avium subspecies paratuberculosis.
Infections normally affect ruminants (mammals that have four compartments of their stomachs, of which the rumen is one),
but have also been seen in a variety of non ruminant species, including rabbits, foxes, and birds. Horses, dogs, and nonhuman primates have been infected experimentally.
Paratuberculosis is found worldwide
Whether your dog is a working companion, champion show animal, hunting partner, or just a best friend, the kindest and most responsible thing you can do for him is to provide proper health care.
Knowing about common dog diseases and being aware of appropriate prevention and treatment can better help you provide that care.
Many Diseases Can Be Prevented .Some of the most common and serious dog diseases have been made less common through vaccines: however, these diseases continue to threaten a dog that lacks proper immunization. Puppies many be vaccinated as early as 4-6 weeks depending on each situation and the veterinarian’s advice. Through mother’s milk, puppies receive disease fighting antibodies, which last 6-16 weeks. Vaccinations then take over.
Yearly boosters should be given throughout your dog’s life, including old age when your dog may become more susceptible to some diseases.
Blood parasites have been subject of extensive research since the beginning of the 20th century. The presence of haemoparasites in animals is very common. In this presentation I presented the most common parasites.
Dr. Fakhar-e-Alam Kulyar
DVM, M.Phil CMS
University of Agriculture Faisalabad
etiology, local names, definition, transmission, source of infection, epidemiology, pathogenesis, clinical signs, diagnosis, differential diagnosis, treatment prevention and control
etiology, local names, definition, transmission, source of infection, epidemiology, pathogenesis, clinical signs, diagnosis, differential diagnosis, treatment prevention and control
This presentation is the third in a four part webinar series on internal parasites in sheep and goats. This presentation focuses on the diagnostic tools available to producers to help them control parasites in the flocks and herds. The presentation is by Susan Schoenian, University of Maryland Extension Sheep & Goat Specialist.
Paratuberculosis is a contagious, chronic and sometimes fatal infection that primarily affects the small intestine of ruminants.
It is caused by the bacterium Mycobacterium avium subspecies paratuberculosis.
Infections normally affect ruminants (mammals that have four compartments of their stomachs, of which the rumen is one),
but have also been seen in a variety of non ruminant species, including rabbits, foxes, and birds. Horses, dogs, and nonhuman primates have been infected experimentally.
Paratuberculosis is found worldwide
Whether your dog is a working companion, champion show animal, hunting partner, or just a best friend, the kindest and most responsible thing you can do for him is to provide proper health care.
Knowing about common dog diseases and being aware of appropriate prevention and treatment can better help you provide that care.
Many Diseases Can Be Prevented .Some of the most common and serious dog diseases have been made less common through vaccines: however, these diseases continue to threaten a dog that lacks proper immunization. Puppies many be vaccinated as early as 4-6 weeks depending on each situation and the veterinarian’s advice. Through mother’s milk, puppies receive disease fighting antibodies, which last 6-16 weeks. Vaccinations then take over.
Yearly boosters should be given throughout your dog’s life, including old age when your dog may become more susceptible to some diseases.
Blood parasites have been subject of extensive research since the beginning of the 20th century. The presence of haemoparasites in animals is very common. In this presentation I presented the most common parasites.
Dr. Fakhar-e-Alam Kulyar
DVM, M.Phil CMS
University of Agriculture Faisalabad
etiology, local names, definition, transmission, source of infection, epidemiology, pathogenesis, clinical signs, diagnosis, differential diagnosis, treatment prevention and control
etiology, local names, definition, transmission, source of infection, epidemiology, pathogenesis, clinical signs, diagnosis, differential diagnosis, treatment prevention and control
This presentation is the third in a four part webinar series on internal parasites in sheep and goats. This presentation focuses on the diagnostic tools available to producers to help them control parasites in the flocks and herds. The presentation is by Susan Schoenian, University of Maryland Extension Sheep & Goat Specialist.
A presentation on small ruminant health by University of Maryland Extension Sheep & Goat Specialist Susan Schoenian. Health topics include biosecurity, the healthy
Panduan menambah baik pengeluaran kambing di kawasan tropika seperti di Malaysia, Indonesia, Filipina dan lain-lain kawasan tropika.
Tajuk: Improving goat production in the tropics: a manual for development workers
Penulis: Christie Peacock
Penerbit: Ox Farm
Kerjasama: FARM-Africa
Tahun: 1996
Slide presentation to train new veterinary assistant employees how to set up a fecal flotation test and vocabulary associated with common endoparasites in small animal practice.
PowerPoint presentation for online FAMACHA certification in 2020. Susan Schoenian, University of Maryland Extension. You can apply for online FAMACHA certification by watching this video, passing quiz, and submitting video of yourself demonstrating proper FAMACHA scoring. If you meet the certification requirements, you will receive a certificate of competence and be able to purchase a FAMACHA card from the University of Maryland. If you are interested, contact Susan Schoenian at sschoen@umd.edu.
This PowerPoint presentation is the second in a four-part webinar series on worms (in sheep and goats). The presentation covers integrated parasite management (IPM): host immunity, pasture and grazing management, nutrition, management, and genetics. The presentation is by Susan Schoenian, University of Maryland Extension Sheep & Goat Specialist.
prevalence of fasciola hepatica in domesticated animal and its control and pr...manojj123
Fasciola hepatica also called (Liver fluke) is a parasitic disease caused by infection of trematode belongs to genus (F. hepatica, F. gigentica). Fasciola hepatica is distributed worldwide and cause great economic loss in livestock sector. Infected animal become anemic and loss of significant amount of weight.
Introduction to AI for Nonprofits with Tapp NetworkTechSoup
Dive into the world of AI! Experts Jon Hill and Tareq Monaur will guide you through AI's role in enhancing nonprofit websites and basic marketing strategies, making it easy to understand and apply.
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
• The Committee on Ways and Means has been investigating several universities since November 15, 2023, when the Committee held a hearing entitled From Ivory Towers to Dark Corners: Investigating the Nexus Between Antisemitism, Tax-Exempt Universities, and Terror Financing. The Committee followed the hearing with letters to those institutions on January 10, 202
Exploiting Artificial Intelligence for Empowering Researchers and Faculty, In...Dr. Vinod Kumar Kanvaria
Exploiting Artificial Intelligence for Empowering Researchers and Faculty,
International FDP on Fundamentals of Research in Social Sciences
at Integral University, Lucknow, 06.06.2024
By Dr. Vinod Kumar Kanvaria
Acetabularia Information For Class 9 .docxvaibhavrinwa19
Acetabularia acetabulum is a single-celled green alga that in its vegetative state is morphologically differentiated into a basal rhizoid and an axially elongated stalk, which bears whorls of branching hairs. The single diploid nucleus resides in the rhizoid.
The French Revolution, which began in 1789, was a period of radical social and political upheaval in France. It marked the decline of absolute monarchies, the rise of secular and democratic republics, and the eventual rise of Napoleon Bonaparte. This revolutionary period is crucial in understanding the transition from feudalism to modernity in Europe.
For more information, visit-www.vavaclasses.com
Normal Labour/ Stages of Labour/ Mechanism of LabourWasim Ak
Normal labor is also termed spontaneous labor, defined as the natural physiological process through which the fetus, placenta, and membranes are expelled from the uterus through the birth canal at term (37 to 42 weeks
Safalta Digital marketing institute in Noida, provide complete applications that encompass a huge range of virtual advertising and marketing additives, which includes search engine optimization, virtual communication advertising, pay-per-click on marketing, content material advertising, internet analytics, and greater. These university courses are designed for students who possess a comprehensive understanding of virtual marketing strategies and attributes.Safalta Digital Marketing Institute in Noida is a first choice for young individuals or students who are looking to start their careers in the field of digital advertising. The institute gives specialized courses designed and certification.
for beginners, providing thorough training in areas such as SEO, digital communication marketing, and PPC training in Noida. After finishing the program, students receive the certifications recognised by top different universitie, setting a strong foundation for a successful career in digital marketing.
Synthetic Fiber Construction in lab .pptxPavel ( NSTU)
Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
Integrated parasite management (IPM) in small ruminants
1. Integrated Parasite Management
(IPM) in Small Ruminants
SUSAN SCHOENIAN
Sheep & Goat Specialist
University of Maryland Extension
sschoen@umd.edu
www.sheepandgoat.com
www.wormx.info
SMALL RUMINANT PROGRAM
2. AMERICAN CONSORTIUM
FOR SMALL RUMINANT
PARASITE CONTROL (ACSRPC)
www.acsrpc.org – www.wormx.info
•Veterinarians
•Parasitologists
•Animal scientists
•Extension specialists
3. Internal Parasites
#1 health problem in sheep and goats in warm, moist climates
Sheep and especially goats are the
most susceptible livestock to internal
parasites (because?)
Close grazing, especially by sheep
Graze close to fecal pellets
Slow-to-develop immunity, esp. goats.
Temporary loss of immunity at parturition
Affected by one of deadliest parasites
We can no longer rely on
anthelmintic treatments alone to
control parasites; a more integrated
approach is necessary.
Few anthelmintics are FDA-approved for
sheep; even fewer for goats.
Worms have developed resistance to all
anthelmintics and anthelmintic classes.
Can’t count on many new drugs.
anthelmintic = dewormer = drench = anti-parasitic drug
4. Haemonchus contortus
The Barber Pole Worm
A blood-sucking parasite
(roundworm) that pierces the
mucosa of the abomasum
(ruminant “stomach”) and
causes blood plasma and
protein loss to the sheep,
goat, or camelid.
I want your
blood!
0.05 ml blood per day
Female worm
5. Barber Pole Worm
Symptoms
Anemia: pale mucous
membranes
Submandibular edema
(bottle jaw)
NOT diarrhea (scours)
Ill thrift
Sudden DEATH
Difficult to control
Short, direct life cycle
Prolific egg producer
Can go into “hypobiotic”
(arrested) state during
adverse environmental
conditions (e.g. winter)
Can survive on pasture
for a long time.
→ Adaptable to environment
Bottle jaw
Pale mucous
membranes
Weight loss, unthrifty
Rough hair coat
6. Other gastro-intestinal (round)
worms from strongyle family
Direct life cycles
Burrow into the wall of the
abomasum or intestines.
→ Usually secondary in importance.
→ Usually have an additive effect in
mixed parasitic infections.
Symptoms: scouring, weight loss,
rough hair coat, ill thrift, poor
appetite.
*Trichostrongylus
Teladorsagia (Ostertagia)
7. Fecal egg counts - Larvae ID
2009 Western Maryland Pasture-Based Meat Goat Performance Test
8. Tapeworms
Moniezia spp.
Indirect life cycle
Worms live in the small intestines.
Eggs pass out through feces (in segments)
The egg is eaten by a pasture mite.
The egg hatches.
The mite is eaten by the sheep or goat.
It is the only parasite we can see in the
feces – that’s why we don’t like it!
Light/moderate loads of tapeworms tend
not to be a problem, but heavy infestations
could cause an intestinal blockage or affect
gut motility.
Tapeworms are generally considered to be
non-pathogenic.
Treat with albendazole or praziquantel.
→ Deworming for tapeworms has not been
shown to increase performance in lambs.
Pasture mite
9. Lungworms
Can have indirect or direct life
cycle.
Transmitted in feces.
Difficult to see in fecal sample
(larvae) – different procedure
is needed.
Severe infestations can result
in coughing, fluid on lungs,
pneumonia.
Difficult to diagnose in live
animal; diagnosis is usually
via necropsy.
Most drugs which kill stomach
worms kill lung worms.
10. Liver flukes
Fasciola hepatica
Generally not considered to be a
problem in Mid-Atlantic area.
Gulf states and Pacific Northwest.
Require open water and aquatic
snails (wet conditions) as
intermediate hosts.
Can kill adult liver flukes with
Albendazole (Valbazen®) or
Ivomec® Plus (Plus=clorsulon).
11. Coccidia
Eimeria spp. (host-specific)
Normal inhabitant of ruminant’s
GI system.
More than 10 species affect sheep
or goats.
Not all are pathogenic or equally
pathogenic.
Single-cell protozoa that damage
the lining of the small intestines,
affecting absorption of nutrients.
Causes diarrhea that may be
smeared with blood and/or
mucous.
Signs of disease occur ~17 days
after infection (ingestion of
oocysts).
Damage can be permanent!
Prevent with good sanitation and
management.
Fecal samples are of limited
value in diagnosing coccidiosis.
12. Coccidia
Eimeria spp. (host-specific)
Can use additives in feed,
mineral, or water to help
prevent clinical disease in
groups of animals:
Lasalocid (Bovatec®)13
Monensin (Rumensin®)23
Decoquinate (Deccox®)12
Amprolium (Corid®) in
water
Sericea lespedeza may help
to control coccidia.
Treat (individual animals)
with Amprolium or sulfa
drugs (requires Rx).
1FDA-approved for sheep
2FDA-approved for goats
3TOXIC to EQUINES!
13. Meningeal worm (deer, brain worm)
Parelaphostrongylus tenuis
Parasite of the White Tail Deer
Small ruminants are abnormal hosts
for the parasites.
sheep, goats, llama, alpaca, horse
Parasite has indirect life cycle
Terrestrial snails and slugs are needed
as intermediate host
Once ingested, larva travel from
intestinal tract to spinal cord to brain,
causing progressively worse
symptoms . . .
Lameness
Gait abnormality
Hind quarter weakness
Paralysis
DEATH
Animals often maintain appetite
Cannot easily diagnose in
a living sheep/goat
(necropsy or spinal fluid)
14. Treatment
No proven treatment
High doses of anthelmintics
Ivermectin (Ivomec®)
Fenbendazole (SafeGuard®)
Steriods
(anti-inflammatory drugs)
Some recover on their own.
Some do not respond to Tx.
Cannot repair damaged tissue.
Prevention
Restrict access to certain
areas of pasture, certain times
of year.
Control deer population
Control snail/slug population
Monthly deworming with
ivermectin.
LongRange™
Meningeal worm
Fencing to exclude deer
is not usually practical.
15. How do you know what kind of
worms your sheep or goats have?
16. Parasite identification
1) Fecal flotation or egg count
Can differentiate between strongyle
(stomach), tapeworm, and coccidia
eggs.
Can’t differentiate between most
strongyle (stomach) worm eggs.
eggs (except Nematodirus)
Meningeal worm does not pass eggs
Do-it-yourself
• Public lab
• Diagnostic lab
• Private lab
• Veterinarian Eimeria spp.
Moniezia spp.
17. Stomach worm identification
2) Fecal coproculture / larvae ID
Differentiate between strongyle
(stomach) worms (H. contortus,
Teladorsagia, and trichostrongyles)
• University of Georgia
(Dr. Ray Kaplan’s lab)
Can take test one step further to determine
anthelmintic resistance -- larval development
assay (LDA) or DrenchRite® test.
3) Lectin-staining test (new)
Determine percent of Haemonchus
contortus eggs in sample.
• Oregon State University
• University of Georgia
18. How do sheep and goats
get infected with parasites?
sheep/goats + grazing (pasture) = worm infection
L3’s infective larvae ingested L4’s and adults suck blood
19. Life Cycle of Stomach Worms
Eggs require warmth (60°F) and humidity to hatch to first stage larvae.
Worm problems vary by
location, farm, year, and season.
20. S O NA J AM J DM JFJ
When Are Larva On Pasture A Problem?
Why & How Do Seasonal Increases Occur?
Lambing Rise
Spring Rise
FEC
Nov 1st
( If No Treatment)
21. JMF AM J A S O N D J
Spring WinterFallSummer
F
Fecal Egg Counts
(What happens in ewes and lambs)
Lambing
Weaning
Ewes
Lambs
22. Population Demographics of
Gastrointestinal Nematodes
Haemonchus
contortis
May-June July-September
How long before
high pasture
infectivity?
3 weeks1 2 weeks1
When are the
highest levels of
pasture infectivity?
5-9 weeks 3-9 weeks
How long until low
levels of pasture
infectivity?
3 months 3 months
1 Earlier if high temperatures coincided with rain.
Patterns of Ostertagia circumcincta, Trichostrongylus spp. and Cooperia curticei were basically
similar to H. contortis. Strongyloides papillosus larvae emerge within 2 weeks on pasture and
survival is short. Nematodirus larvae took a lot longer to emerge on pasture than the other
trichostrongylids.
Utrecht University (Netherlands) 1999-2003
Research conclusion: Only a small number of farms can use evasive grazing
as the only method of parasite control. For most farms, evasive grazing
needs to be combined with other pasture control strategies.
23. Integrated Parasite
Management (IPM)
Goal is not to create parasite-free animals. It is
normal for sheep and goats to have parasites. Goal
is to prevent clinical disease and production losses.
24. Consider host resistance
Most susceptible
Weaned lambs and kids
Orphan lambs and kids
Yearlings
High producing females
Late -born lambs and kids
Geriatric animals
Goats
Unadapted breeds
Less susceptible
Mature animals
Males
Dry ewes
Pets
Mature wethers
Sheep
25. Parasite control begins with good
management and common sense
Good sanitation.
Use of feeders which prevent
wastage and contamination.
Clean water, free from fecal
matter and other debris.
Avoid overstocking pens and
pastures.
Isolate and deworm new
additions to the farm.
The primary cause of internal
parasitism is overstocking.
26. JMF AM J A S O N D
Spring FallSummer
Weaning
J
Winter
Lambing
Kidding
Market by July 1
Winter lambing/kidding
27. JMF AM J A S O N D
Spring FallSummer
Weaning
J
Winter
Lambing
KiddingEarly marketing
Fall lambing and kidding
28. Use of “clean or safe” pastures
New pasture
A pasture that has been renovated
with tillage.
A pasture that has not been grazed
by sheep or goats for the past 6 to 12
months.
A pasture that has been grazed by
horses and/or cattle for the past 6 to
12 months.
A pasture in which a hay or silage
crop has been removed.
A pasture that has been rotated with
row crops.
Pasture that has been burned
Severely overgrazed pasture????
Cleaner, safer pastures are a more realistic goal for most producers.
29. Graze multiple species
Sheep and goats share the same
internal parasites, but they are
different from the parasites that
affect cattle and horses.
Except barber pole worm in young calves.
Producers who graze multiple
species of livestock report fewer
parasite problems.
Cattle and horses “vacuum”
sheep/goat pastures of infective
worm larvae.
There are other benefits to mixed
species grazing, such as
complimentary grazing habits.
30. Pasture Rest and Rotation
Pasture rotation is a recommended
strategy for controlling internal
parasites because it allows the use
of safe or safer pastures.
BUT, intensive rotational grazing
may not help to reduce parasitism
unless rest periods are long
enough.
Due to increased stocking rates,
management intensive grazing
could increase internal parasite
problems in sheep and goats.
In a rotational grazing system,
ideally, sheep/goats should not be
returned to the same pasture for 2
to 3 months.
31. Alternative forages
Livestock that browse have
fewer parasite problems.
Livestock grazing tall-
growing forages will have
less parasite problems.
80% of parasites live in the
first 2 inches of the
vegetation.
Grazing tanniferous forages
may reduce the effects of
parasitism.
No worm larvae
up here
32. Chicory, birdsfoot trefoil, and
Sericea Lespedeza have all
been shown to reduce fecal
egg counts and/or inhibit
larval development.
Birdsfoot Trefoil
Forage
Chicory
Sericea Lespedeza
33. Sericea lespedeza
Lespedeza cuneata (high tannin variety)
Warm season legume that
grows in acidic soils with low
fertility and tolerates drought
well.
Fed as . . .
Fresh forage
Loose or ground hay
Pelleted supplement (leaf meal)
Goats readily eat.
Sheep will eat.
For control of barber pole worm
May also control coccidiosisImages from acsrpc.org
34. Nutritional Management
Animals on a high plane of
nutrition and in better body
condition are better able to
withstand worm burdens.
Nutrition in early pregnancy (fat
stores) can affect the immune
response to internal parasites.
Sheep receiving higher levels of
protein prior to lambing have
lower fecal egg counts.
Supplementing grazing lambs with
protein has been shown to reduce
fecal egg counts.
Nutritional supplementation is most likely to be beneficial when pregnant females and young animals
are below optimal body condition at a time when pasture quality and/or quantity is limited.
35. “Zero” grazing
bedded pens, dry lot with no green vegetation, slatted floors
Sheep/goats raised in
confinement or dry lot
(zero grazing) tend to
have fewer worm
problems.
Sheep/goats put in
confinement or dry lot do
not usually get re-
infected with worms.
Coccidiosis could still be
a problem, if
preventative measures
are not taken.
Good sanitation
Proper feeders
Coccidiostats
0
200
400
600
800
1000
1200
1400
1600
1800
Avg. Fecal egg counts (FEC, epg)
37. “Resistant” Breeds
Some sheep and goat breeds are more resistant and resilient to worms.
Sheep
Natives
Gulf Coast, Florida, Louisiana
Hair sheep
St. Croix
Barbados Blackbelly
Katahdin
NOT
Traditional wooled
breeds
Maybe
Dorper (resilient?)
Royal white
Other
Texel (?)
Goats
Indigenous
Spanish
Myotonic/Tennessee Fainting
Kiko
NOT
Boer goats
Dairy goats
Angora goats
Not sure
Pygmy
Savannah
There is less data comparing
parasite resistance in goat breeds.
38. “Resistant” animals
There is as much difference within breeds as between breeds.
The 80-20 rule (70:30)
Approximately 20 percent of
the flock sheds most (~80
percent) of the parasite eggs.
Focusing deworming on
susceptible animals will
significantly reduce pasture
contamination.
Culling worm-susceptible
animals will increase flock
resistance and reduce
pasture contamination.
Only resistant males should
be used for breeding!
39. Distribution of FECs in a herd
0
2,000
4,000
6,000
8,000
10,000
12,000
14,000
16,000
EPG, August 29, 2009
40. Heritability of FEC and PCV
FEC
(resistance)
PCV
(resilience)
Ewes 0.31 0.15
Lambs 0.10 0.39
2004, Vanimisetti, Andrew, Zazac, Notter
Selection for
parasite resistance
is possible and will
not adversely affect
growth of lambs and
fertility of ewes.
41. Comparison of Genetic and
Non-genetic Control Strategies
Strategy Reduction in FEC’s
Genetic Selection 69%
Protein supplementation 35%
Strategic deworming 28%
Experimental vaccine 0%
Australia, 2002
•Monitor sheep, run in the plots after the end of the experiment had
lower FEC’s when run in the plots previously grazed by
supplemented sheep (35%) or selected sheep (46%).
•The largest and most persistent effect on FEC’s and worm
contamination of pasture was achieved by genetic selection.
43. Three drug families
Drugs kill parasites by starving them or paralyzing them.
1) Benzimidazoles
Chemical name ends in '..dazole
Fenbendazole, Albendazole,
Oxybendazole
2) Nicotinics
a) Imidazothiaoles
Levamisole
b) Tetrahydropyrimidines
Morantel, Pyrantel
3) Macrolytic lactones
a) Avermectins
Ivermectin, Doramectin
b) Milbemycins
Moxidecin
44. Benzimidazoles
“white drenches”
1. Fenbendazole
SafeGuard®,
Panacur®
2. Albendazole
Valbazen®
3. Oxyfendazole
Synantic ®
First class of modern
anthelmintics.
Most broad spectrum:
adult and L4 larvae
hypobiotic larvae
Tapeworms
liver flukes
Wide margin of safety
→ High level of resistance
across industry.
45. Albendazole
Valbazen® drench
FDA-approved for sheep
(7 day slaughter withdrawal).
Labeled for control of liver flukes in non-
lactating goats (7 day slaughter withdrawal)
For control of …
1. Adult and 4th stage larvae of GI worms
2. Varying levels of activity against hypobiotic
larvae.
3. Adult and larval forms of lungworms
4. Heads and segments of tapeworms
5. Adult liver flukes
Safe, but use restricted during pregnancy
(1st 30 days).
Widespread resistance across industry.
Fast animals to improve efficacy.
46. Fenbendazole
SafeGuard®, Panacur® drench
FDA-approved for goats (6 day
slaughter withdrawal).
Labeled dosage should be doubled
(per Intervet).
For control of adult GI worms and
L4 larvae.
Widespread resistance across
industry.
Fast animals to improve efficacy.
Double dosage will kill heads and
segments of tapeworms.
One of the preferred drugs for
treating meningeal worm.
48. Levamisole
Prohibit®, Levasole®, Tramisol® drench or oblets
FDA-approved for sheep
(3 days slaughter withdrawal)
For control of
Adult and L4 larvae stages of GI
worms
Hypobiotic larvae (?)
Adult and larvae forms of lungworm
→ Probably the most effective
anthelmintic.
Lowest margin of safety
Treat based on accurate weights
Administer orally.
Goats – 1.5x sheep dose
49. Rumatel
Morantel tartrate
Medicated feed.
Best to feed goats individually.
FDA-approved for all classes of
goats .
For control of mature worms
only.
30-day slaughter withdrawal.
Not much is known about its
efficacy or resistance.
50. Macrolides
(Macrolytic lactones, ML’s)
1) Avermectins
Ivermectin
Ivomec®, Zimecterin®,
Eprinex®, Promectin®
Doramectin
Dectomax®
2) Milbemycins
Moxidectin
Cydectin®, Quest®
Newest
Broad spectrum
Adult and L4 larvae GI worms
Hypobiotic larvae
Adults and larvae stages of
lungworm
External parasites (biting)
Wide margin of safety
Persistent activity
51. Avermectins: Ivermectin
Ivomec® drench
Introduced in the 1980’s.
Drug of choice for meningeal
worm.
For control of . . .
Adult and L4 larvae GI worms
Hypobiotic larvae
Adult and larvae lungworms
Larval stages of nosebot
11-day slaughter withdrawal
High levels of resistance in
industry.
Fast animals to improve efficacy
52. Moxidectin
Cydectin® drench
Newest drug (1997).
For control of mature and L4
larval stages of GI worms.
7-day slaughter withdrawal
Similar to ivermectin, but
disrupts different chemical
neurotransmitter.
May kill ivermectin-resistant
worms.
Due to similarity to Ivermectin,
resistance will develop rapidly if
it is overused.
53. Extra-label Drug Use
Only Fenbendazole
(SafeGuard®) and Morantel
(Rumatel®) are FDA-approved
for goats – and only at dosages
listed on label.
Albendazole (Valbazen®),
Ivomec® drench, Cydectin
drench, and Levamisole
(drench and bolus) are FDA-
approved for sheep.
Use of a product that is
different from its label
constitutes extra-label drug
use and requires a veterinary
prescription and valid
veterinarian-patient-client
relationship.
54. Withdrawal for extra-label drugs
Use longer withdrawals
for extra-label drugs.
Meat withdrawal for
Cydectin® drench is 23
days when administered to
goats at double the dosage
as compared to 7 days for
sheep. (source: farad.org)
Meat withdrawal is 120-130
days for Cydectin® 1%
injectable when
administered to goats as
compared to 21 days for
cattle. (source: farad.org)
Keep records of
anthelmintic use.
55. The future of parasite control
1) New anthelmintics
Zolvix®
2) Natural “dewormers”
• COWP
• Others
3) Vaccination
• “Paravac” consortium
4) Gene-marker assisted
selection
56. Zolvix® (monepantel)
New drug class
Amino-acetonitrile derivative (ADD)
Unique mode of action
First new anthelmintic class in 25 years
Kills worms that are resistant to other
anthelmintics
Currently only registered for use in New Zealand,
Great Britain, and Uruguay.
Testing is complete in US; waiting for company to
release it.
Will it be approved for goats?
Overuse will cause worms to develop resistance
to it just like the other drugs.
57. Natural “anthelmintics”
Diatomaceous earth
Pumpkin seed
Garlic
Papaya
Tobacco
Wormwood
Others
Natural “anthelmintics” have
not been shown to be effective
at treating parasitism, but
perhaps their use will reduce
the number of animals that
require treatment.
59. Anthelmintic resistance
How to measure
Fecal Egg Count Reduction
Test (FECRT)
Conduct fecal egg count before
deworming
Fecal egg count 7-10 days after
deworming
Control group to confirm
resistance/efficacy.
DrenchRite® (Univ. of GA)
Larval development assay
(LDA)
Drug resistance
< 95 % egg reduction
Severe Resistance
< 60 % egg reduction
** Caused by overuse and misuse of drugs. **
60. Anthelmintic resistance
SafeGuard® & Valbazen®
Widespread resistance
Levamisole
Still Effective in many places
Ivermectin
Widespread resistance
Moxidectin
Mostly effective
** Caused by overuse and misuse of drugs. **
61. Slowing Down Drug Resistance
DO NOT overuse drugs, especially
Levamisole and Moxidectin.
DO NOT introduce resistant-worms to
your farm
Isolate new animals and deworm
them with anthelmintics from two
different chemical classes.
DO NOT underdose
Weigh animals or dose for heaviest
animals in group.
DO NOT rotate dewormers after each
treatment
Rotate dewormers annually
Rotate among drug families
Use specific dewormers for specific
situations.
DO NOT treat everybody
Leave some animals untreated
62. “Refugia”
In refuge from the drug
What is refugia?
Worms not exposed to
drug;therefore still
susceptible to treatment.
The goal
Increase the population of
susceptible worms.
How?
Selective treatment –
leave some animals
untreated.
After deworming, do not
move animals to a clean
pasture.
You do not have to deworm every animal.
63. Parents How We Select for
Drug resistance
Resistant
Next Generation
Resistant
Drug Treatment
64. Maximize the effect of a
single treatment
Give proper dose; do not
underdose.
Dose orally.
Deposit anthelmintic in esophagus
(not mouth) to prevent drug from
by-passing rumen.
Fast animals to increase efficacy of
some drugs.
Use higher dose for goats than
listed on label. Goats usually
require 1.5-2X the sheep/cattle
dose.
Consult with veterinarian for proper dose
for goats.
Use drugs from two different
chemical classes to get a
synergistic effect.
65. Routes of administration
Oral
Drench/oblets
Medicated
Pellet
Injectable Pour-On
FDA-approved
Most effective ?
Shorter withdrawal
Easier to administer
Safer
FDA-approved
Easy to administer
Sick animal won’t eat
Accurate dosage???
Not FDA-approved
Stays in system longer,
accelerating drug
resistance
Longer withdrawal
Potential for abscesses
Less expensive
Not FDA-approved
Not formulated for
sheep and goats
Accelerates drug
resistance.
Oral Paste/Gel
Not FDA-approved
Hard to calibrate
Hard to administer over tongue
Most expensive
Don’t have to buy as much
Choose . . .
1- Sheep Products
2- Cattle Products
3- Horse Products
66. Periparturient egg rise
Temporary loss of immunity to
parasites at the time of
parturition. Egg counts ↑
Often coincides with hypobiotic
larvae resuming their life cycles
in the spring.
Dams are the primary source of
infection to their offspring.
Management options
Deworm with an anthelmintic that is
effective against hypobiotic larvae.
Increase protein in late gestation ration
to counter egg rise.
69. Fecal Egg Counting
Qualitative Analysis
Shows presence or
absence of eggs
Identify egg types
Shows general trends
in egg numbers.
Quantitative Analysis
Shows specific
number of eggs per
gram of feces (epg)
Uses known quantity
of feces and flotation
solution.
70. Fecal Egg Counting
What you need
Microscope (min. 100x)
Flotation solution
Mixing vial
• Mixing vial and strainer for
qualitative analysis
• Calibrated mixing vial and
syringe for quantitative
analysis
Slides
• Regular slides and cover
slips for qualitative
analysis.
• McMaster egg counting
slide for quantitative
analysis
71. What do fecal egg counts tell you?
Potential pasture contamination.
Fecal egg counts are not
mathematically correlated to
worm numbers or the severity of
parasitic disease.
Monitor and maintain low egg
counts; deworm when appropriate
to keep contamination of pasture
low.
Determine the efficacy of
anthelmintic treatment by
comparing paired samples from
the same animals (treatment and
control group).
Compare parasite resistance
among animals in the same
contemporary group.
72. Paracount-EPG™ Fecal Analysis Kit
Chalex Corporation
(Advanced Equine Products)
5004 – 228th Ave. SE
Issaquah, WA 98029
(425) 391-1169
chalexcorp@att.net
http://vetslides.com
$50-60 for kit
$15 each for two slides
$20 for green grid
77. Precautions
• Only useful where Haemonchus
contortis is the primary parasite
species.
• Cannot be used in a vacuum; other
factors need to be considered when
making treatment decisions. Ex:
Bottle jaw
Body condition
Fecal consistency
Evidence of scouring
Age and susceptibility of animal
• There are other causes of pale or
red eye lids.
• Should be incorporated into an
integrated parasite management
(IPM) program that includes proper
anthelmintic use, pasture rest and
rotation, fecal egg counting, mixed
species grazing, etc.)
78. Must know if anthelmintic is
effective.
FECRT
DrenchRite®
How often should you check
animals?
Depends on season and
weather
Always use card! Compare eye
color to chart. Replace card
after 12 months of use.
Should only be used by
properly trained individuals;
improper use can lead to death
of animals.
Precautions