Stylesheet Wrangling with SCSS provides tips for optimizing CSS for performance. It recommends using efficient selectors, minimizing stylesheet length and HTTP requests, and optimizing images. SCSS features like mixins, extends, placeholders and variables can help organize CSS. Nesting selectors leads to bloated CSS, so using class names with minimal nesting is better. Proper file structure and organization is also important for optimizing CSS. Tools like Compass, Grunt, and dev tools in browsers can help benchmark and optimize CSS.