1. Genetic and Molecular Characterization of a Dental Pathogen Using a Genome-Wide Approach

3. The Microbial Oral Community A. H. Rickard et al ., Trends Microbiol. 2003

4. The Microbial Oral Community A. H. Rickard et al ., Trends Microbiol. 2003

5. Microbial Genome Sequencing Projects NIDCR Initial Recommendation

6. Microbial Genome Sequencing Projects Supported by NIDCR

7. Los Alamos National Laboratory The Oral Pathogen Sequence Databases

8. Status of Oral Pathogen Genomes Data obtained from: † , Genomes OnLine Databases (GOLD) *, TIGR Databases * †

10. Facts About Iron

11. Facts About Iron

12. Siderophore-dependent Main Bacterial Iron Acquisition Systems

13. Siderophore-dependent Siderophore-independent Main Bacterial Iron Acquisition Systems

14. Gene Regulation by Fur and sRNA

15. Gene Regulation by Fur and sRNA

19. Comparative Analysis of A.a. Strains by PCR and DNA Sequencing + ND ND + hgpA + + + + tonB + + + + fur + + + + afeD + + + + afeC + + + + afeB CU1000 SUNY465 Y4 HK1651 + + + + afeA + + + + afuC + + + + afuB + + + + afuA

20. Iron Acquisition from Different Sources by CU1000(rough) and CU1060 (smooth) + + Utilization of FeCl 3 + +++ Binding of heme + + Utilization of heme ND ND Binding of hHb - - Utilization of hHb CU1060 CU1000 + + + Binding of hLf - - Utilization of hLf - - Binding of hTf - - Utilization of hTf

21. Gene Regulation by Fur Expression of Fur Expression of iron-regulated proteins

29. Reconstruction of S. mutans metabolic pathways and transport systems

32. Analysis of the P. aeruginosa Iron Regulon Analysis of gene expression in cells cultured under iron-rich and iron-limiting conditions using GeneChip ® arrays

33. Analysis of the P. aeruginosa Iron Regulon Analysis of gene expression in cells cultured under iron-rich and iron-limiting conditions using GeneChip ® arrays U. A. Ochsner et al ., 2002