25. [D] (concentration units) % Maximal Effect 0.01 0.10 1.00 10.00 100.00 1000.00 0.0 0.2 0.4 0.6 0.8 1.0 Partial agonist Full Agonist Partial agonist PARTIAL AGONISTS - EFFICACY Even though drugs may occupy the same # of receptors, the magnitude of their effects may differ.
26.
27.
28.
29.
30.
31.
32. What is the difference between Quantal and graded dose-response curves?
33.
34. Graded dose response curves show effects on a continuous scale And the intensity of the effect is proportional to the dose
38. Plot of the contraction of the intestinal smooth muscle in response to varied doses of acetylcholine
39.
40.
41.
42.
43.
44.
45.
46.
47.
48.
49.
50.
51.
52. BELL SHAPED CURVE majority of responders in the middle mean response is approx. 110 mg/kg fewer responders at the end of bell curve (expected) known as biological variability responders at the far left of the mean are typically hypersusceptible whereas those at the far right are resistant