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Physio Gi Hormones13.
1.
Endocrine Control of
Gastrointestinal Function Dr.Mohammad Shaikhani
2.
GI Hormones Glucose,
AA Fatty acids Duodenum Jejunum Insulin secretion Gastric acid secretion GIP Acid fat Duodenum Pepsin secretion Pancreatic juice secretion enzymes bicarbonate Pancreatic exocirne growth Secretin Peptides, AA Fatty acids>8C Acid Duodenum Jejunum Gall Bladder contraction Pancreatic juice secretion enzyme bicarbonate Pancreatic exocirne growth CCK Peptides, AA Distention Vagal activity Antrum duodenum Gastric acid secretion Growth of oxyntic gland mucosa Gastrin Secretion stimulus Release site Action Hormone
3.
GI Hormones Glucose
Fat Ileum unknown Enteroglucagon Protein Fat Glucose Pancreas Pancreatic juice secretion enzyme bicarbonate Pancreatic polypeptide Unknown Duodenum Jejunum Gastric and duodenal motility Motilin Secretion stimulus Release site Action Peptide
4.
Neurocrines Gastric mucosa
Muscosa and smooth muscle of GI tract Stimulates gastrin secretion Stimulates smooth muscle contraction Inhibits intestinal secretion Bombesin or GRP Enkephalins Duodenum Jejunum Relaxes sphincters Relaxes gut circular muscle Stimulates intestinal secretion Simulates pancreatic secretion VIP Release site Action Peptide
5.
6.
7.
8.
CCK: most important
stimulus for gall bladder contraction & release of bile into small intestine
9.
10.
11.
12.
13.
14.
15.
16.
17.
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